Zentrum für Neuropathologie und Prionforschung
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Dr. med. Dr. Mario Dorostkar

[2019] [2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004]

2019

Neumann JE, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar MM, Wefers AK, Frank S, Monoranu CM, Koch A, Witt H, Kool M, Pajtler KW, Rutkowski S, Glatzel M & Schüller U
Molecular characterization of histopathological ependymoma variants.
Acta neuropathologica, 2019 Nov 02

Focke C, Blume T, Zott B, Shi Y, Deussing M, Peters F, Schmidt C, Kleinberger G, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Ozmen L, Baumann K, Dorostkar MM, Haass C, Adelsberger H, Herms J, Rominger A & Brendel M
Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019 Apr, 60 (4) 548-554

2018

Unterrainer M, Diekmann C, Dorostkar M, Vettermann FJ, Kümpfel T, Tonn JC, Bartenstein P & Albert NL
Neurosarcoidosis Mimics High-Grade Glioma in Dynamic 18F-FET PET Due to LAT Expression.
Clinical nuclear medicine, 2018 Nov, 43 (11) 840-841

Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, Dorostkar M, Shimshek DR, Brose N, Neumann U & Herms J
BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.
Acta neuropathologica, 2018 May, 135 (5) 695-710

Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM & Herms J
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
Biological psychiatry, 2018 Mar 01, 83 (5) 428-437

2017

Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Müller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M & Schüller U
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.
Nature medicine, 2017 Oct, 23 (10) 1191-1202

Matz G, Messerschmidt B, Göbel W, Filser S, Betz CS, Kirsch M, Uckermann O, Kunze M, Flämig S, Ehrhardt A, Irion KM, Haack M, Dorostkar MM, Herms J & Gross H
Chip-on-the-tip compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medicine and biomedical research.
Biomedical optics express, 2017 Jul 01, 8 (7) 3329-3342

Blazquez-Llorca L, Valero-Freitag S, Rodrigues EF, Merchán-Pérez Á, Rodríguez JR, Dorostkar MM, DeFelipe J & Herms J
High plasticity of axonal pathology in Alzheimer's disease mouse models.
Acta neuropathologica communications, 2017 Feb 07, 5 (1) 14

Vettermann FJ, Neumann JE, Suchorska B, Bartenstein P, Giese A, Dorostkar MM, Albert NL & Schüller U
K27M midline gliomas display malignant progression by imaging and histology.
Neuropathology and applied neurobiology, 2017 Aug, 43 (5) 458-462

Montagna E, Dorostkar MM & Herms J
The Role of APP in Structural Spine Plasticity.
Frontiers in molecular neuroscience, 2017, 10 136

2016

Neumann JE, Dorostkar MM, Korshunov A, Mawrin C, Koch A, Giese A & Schüller U
Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients.
Journal of neuropathology and experimental neurology, 2016 May, 75 (5) 408-14

Herms J & Dorostkar MM
Dendritic Spine Pathology in Neurodegenerative Diseases.
Annual review of pathology, 2016 May 23, 11 221-50

Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC & Herms J
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.
The EMBO journal, 2016 Oct 17, 35 (20) 2213-2222

2015

Klinger F, Bajric M, Salzer I, Dorostkar MM, Khan D, Pollak DD, Kubista H, Boehm S & Koenig X
δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.
British journal of pharmacology, 2015 Oct, 172 (20) 4946-58

Reiter FP, Giessen-Jung C, Dorostkar MM, Ertl-Wagner B, Denk GU, Heck S, Rieger CT, Pfister HW & op den Winkel M
Miliary pattern of brain metastases - a case report of a hyperacute onset in a patient with malignant melanoma documented by magnetic resonance imaging.
Radiation oncology (London, England), 2015 Jul 19, 10 148

Dorostkar MM, Zou C, Blazquez-Llorca L & Herms J
Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities.
Acta neuropathologica, 2015 Jul, 130 (1) 1-19

Zou C, Montagna E, Shi Y, Peters F, Blazquez-Llorca L, Shi S, Filser S, Dorostkar MM & Herms J
Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.
Acta neuropathologica, 2015 Jun, 129 (6) 909-20

Ochs SM, Dorostkar MM, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian SV & Herms J
Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin.
Molecular psychiatry, 2015 Apr, 20 (4) 482-9

2014

Dorostkar MM, Burgold S, Filser S, Barghorn S, Schmidt B, Anumala UR, Hillen H, Klein C & Herms J
Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model.
Brain : a journal of neurology, 2014 Dec, 137 (Pt 12) 3319-26

Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M & Herms J
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.
Nature communications, 2014 May 28, 5 3915

Burgold S, Filser S, Dorostkar MM, Schmidt B & Herms J
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.
Acta neuropathologica communications, 2014 Mar 28, 2 30

2013

Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M & Herms J
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications, 2013 Dec 17, 1 82

2012

Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, Kretzschmar H & Herms J
Amyloid plaque formation precedes dendritic spine loss.
Acta neuropathologica, 2012 Dec, 124 (6) 797-807

Dorostkar MM & Herms J
Arc illuminates Alzheimer's pathophysiology.
Nature neuroscience, 2012 Oct, 15 (10) 1323-5

Klinger F, Geier P, Dorostkar MM, Chandaka GK, Yousuf A, Salzer I, Kubista H & Boehm S
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
British journal of pharmacology, 2012 Jul, 166 (5) 1631-42

2011

Scheibe S, Dorostkar MM, Seebacher C, Uhl R, Lison F & Herms J
4D in in vivo 2-photon laser scanning fluorescence microscopy with sample motion in 6 degrees of freedom.
Journal of neuroscience methods, 2011 Aug 30, 200 (1) 47-53

Burgold S, Bittner T, Dorostkar MM, Kieser D, Fuhrmann M, Mitteregger G, Kretzschmar H, Schmidt B & Herms J
In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks.
Acta neuropathologica, 2011 Mar, 121 (3) 327-35

2010

Dorostkar MM, Dreosti E, Odermatt B & Lagnado L
Computational processing of optical measurements of neuronal and synaptic activity in networks.
Journal of neuroscience methods, 2010 Apr 30, 188 (1) 141-50

2009

Dreosti E, Odermatt B, Dorostkar MM & Lagnado L
A genetically encoded reporter of synaptic activity in vivo.
Nature methods, 2009 Dec, 6 (12) 883-9

Egaña LA, Cuevas RA, Baust TB, Parra LA, Leak RK, Hochendoner S, Peña K, Quiroz M, Hong WC, Dorostkar MM, Janz R, Sitte HH & Torres GE
Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009 Apr 08, 29 (14) 4592-604

2008

Schicker KW, Dorostkar MM & Boehm S
Modulation of transmitter release via presynaptic ligand-gated ion channels.
Current molecular pharmacology, 2008 Jun, 1 (2) 106-29

Dorostkar MM & Boehm S
Presynaptic lonotropic receptors.
Handbook of experimental pharmacology, 2008, (184) 479-527

2007

2006

Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, Ducza E, Ogris E, Boehm S, Freissmuth M & Nanoff C
The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor.
Molecular pharmacology, 2006 Apr, 69 (4) 1083-94

Goetze B, Tuebing F, Xie Y, Dorostkar MM, Thomas S, Pehl U, Boehm S, Macchi P & Kiebler MA
The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis.
The Journal of cell biology, 2006 Jan 16, 172 (2) 221-31

2005

Hilber B, Scholze P, Dorostkar MM, Sandtner W, Holy M, Boehm S, Singer EA & Sitte HH
Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines.
Neuropharmacology, 2005 Nov, 49 (6) 811-9

2004

Lechner SG, Dorostkar MM, Mayer M, Edelbauer H, Pankevych H & Boehm S
Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.
The European journal of neuroscience, 2004 Dec, 20 (11) 2917-28

Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M & Sitte HH
Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).
The Journal of biological chemistry, 2004 Jul 02, 279 (27) 28553-63