Zentrum für Neuropathologie und Prionforschung
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Professor Dr. Armin Giese

[2019] [2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2001] [2000] [1999] [1998] [1997] [1996] [1995]

2019

Düsterhöft S, Babendreyer A, Giese AA, Flasshove C & Ludwig A
Status update on iRhom and ADAM17: It's still complicated.
Biochimica et biophysica acta. Molecular cell research, 2019 Oct, 1866 (10) 1567-1583

Wegrzynowicz M, Bar-On D, Calo' L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, Ashery U & Spillantini MG
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Acta neuropathologica, 2019 Oct, 138 (4) 575-595

Respondek G, Grimm MJ, Piot I, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Roeber S, Giese A, Grossman M, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Höglinger GU & Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group
Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies.
Movement disorders : official journal of the Movement Disorder Society, 2019 Sep 30

Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ & Vassallo N
Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.
Biochimica et biophysica acta. Biomembranes, 2019 Sep 12, 183064

Ghio S, Camilleri A, Caruana M, Ruf VC, Schmidt F, Leonov A, Ryazanov S, Griesinger C, Cauchi RJ, Kamp F, Giese A & Vassallo N
Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes.
ACS chemical neuroscience, 2019 Aug 21, 10 (8) 3815-3829

Brendel M, Deussing M, Blume T, Kaiser L, Probst F, Overhoff F, Peters F, von Ungern-Sternberg B, Ryazanov S, Leonov A, Griesinger C, Zwergal A, Levin J, Bartenstein P, Yakushev I, Cumming P, Boening G, Ziegler S, Herms J, Giese A & Rominger A
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau.
Alzheimer's research & therapy, 2019 Aug 01, 11 (1) 67

Levin J, Maaß S, Schuberth M, Giese A, Oertel WH, Poewe W, Trenkwalder C, Wenning GK, Mansmann U, Südmeyer M, Eggert K, Mollenhauer B, Lipp A, Löhle M, Classen J, Münchau A, Kassubek J, Gandor F, Berg D, Egert-Schwender S, Eberhardt C, Paul F, Bötzel K, Ertl-Wagner B, Huppertz HJ, Ricard I, Höglinger GU & PROMESA Study Group
Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial.
The Lancet. Neurology, 2019 Aug, 18 (8) 724-735

Grimm MJ, Respondek G, Stamelou M, Arzberger T, Ferguson L, Gelpi E, Giese A, Grossman M, Irwin DJ, Pantelyat A, Rajput A, Roeber S, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Colosimo C, van Eimeren T, Kassubek J, Levin J, Meissner WG, Nilsson C, Oertel WH, Piot I, Poewe W, Wenning GK, Boxer A, Golbe LI, Josephs KA, Litvan I, Morris HR, Whitwell JL, Compta Y, Corvol JC, Lang AE, Rowe JB, Höglinger GU & Movement Disorder Society-endorsed PSP Study Group
How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy.
Movement disorders : official journal of the Movement Disorder Society, 2019 Aug, 34 (8) 1228-1232

Bartels M, Weckbecker D, Kuhn PH, Ryazanov S, Leonov A, Griesinger C, Lichtenthaler SF, Bötzel K & Giese A
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.
Scientific reports, 2019 Jun 24, 9 (1) 9100

Borggraefe I, Tacke M, Gerstl L, Leiz S, Coras R, Blümcke I, Giese A, Ertl-Wagner B, Thiel CT, Noachtar S & Peraud A
Epilepsy surgery in the first months of life: a large type IIb focal cortical dysplasia causing neonatal drug-resistant epilepsy.
Epileptic disorders : international epilepsy journal with videotape, 2019 Feb 01, 21 (1) 122-127

Suchorska B, Schüller U, Biczok A, Lenski M, Albert NL, Giese A, Kreth FW, Ertl-Wagner B, Tonn JC & Ingrisch M
Contrast enhancement is a prognostic factor in IDH1/2 mutant, but not in wild-type WHO grade II/III glioma as confirmed by machine learning.
European journal of cancer (Oxford, England : 1990), 2019 Jan, 107 15-27

Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK & Stefanova N
Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.
Movement disorders : official journal of the Movement Disorder Society, 2019 Feb, 34 (2) 255-263

Baiardi S, Redaelli V, Ripellino P, Rossi M, Franceschini A, Moggio M, Sola P, Ladogana A, Fociani P, Magherini A, Capellari S, Giese A, Caughey B, Caroppo P & Parchi P
Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry, 2019 Apr, 90 (4) 424-427

2018

Biczok A, Kraus T, Suchorska B, Terpolilli NA, Thorsteinsdottir J, Giese A, Tonn JC & Schichor C
TERT promoter mutation is associated with worse prognosis in WHO grade II and III meningiomas.
Journal of neuro-oncology, 2018 Sep, 139 (3) 671-678

Schnell O, Albrecht V, Pfirrmann D, Eigenbrod S, Krebs B, Romagna A, Siller S, Giese A, Tonn JC & Schichor C
MGMT promoter methylation is not correlated with integrin expression in malignant gliomas: clarifying recent clinical trial results.
Medical oncology (Northwood, London, England), 2018 Jun 07, 35 (7) 103

Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A & Zinth W
Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.
Biochimica et biophysica acta. General subjects, 2018 Apr, 1862 (4) 800-807

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H & Walter J
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.
Epigenetics & chromatin, 2018 Jul 25, 11 (1) 41

Suchorska B, Giese A, Biczok A, Unterrainer M, Weller M, Drexler M, Bartenstein P, Schüller U, Tonn JC & Albert NL
Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma.
Neuro-oncology, 2018 Jan 22, 20 (2) 279-288

Böck J, Remmele CW, Dittrich M, Müller T, Kondova I, Persengiev S, Bontrop RE, Ade CP, Kraus TFJ, Giese A, El Hajj N, Schneider E & Haaf T
Cell Type and Species-specific Patterns in Neuronal and Non-neuronal Methylomes of Human and Chimpanzee Cortices.
Cerebral cortex (New York, N.Y. : 1991), 2018 Oct 01, 28 (10) 3724-3739

Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M & FTLDc study group
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Journal of neurology, neurosurgery, and psychiatry, 2018 Mar, 89 (3) 239-247

Franceschini A, Strammiello R, Capellari S, Giese A & Parchi P
Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression.
Neuropathology and applied neurobiology, 2018 Oct, 44 (6) 574-589

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G & Fischer A
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
EMBO molecular medicine, 2018 Jan, 10 (1) 32-47

Unterrainer M, Winkelmann I, Suchorska B, Giese A, Wenter V, Kreth FW, Herms J, Bartenstein P, Tonn JC & Albert NL
Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.
European journal of nuclear medicine and molecular imaging, 2018 Jul, 45 (7) 1242-1249

Unterrainer M, Winkelmann I, Suchorska B, Giese A, Wenter V, Kreth FW, Herms J, Bartenstein P, Tonn JC & Albert NL
Correction to: Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.
European journal of nuclear medicine and molecular imaging, 2018 Jun, 45 (6) 1078

2017

Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Höglinger GU & Movement Disorder Society-Endorsed PSP Study Group
Which ante mortem clinical features predict progressive supranuclear palsy pathology?
Movement disorders : official journal of the Movement Disorder Society, 2017 Jul, 32 (7) 995-1005

Dietrich O, Levin J, Ahmadi SA, Plate A, Reiser MF, Bötzel K, Giese A & Ertl-Wagner B
MR imaging differentiation of Fe2+ and Fe3+ based on relaxation and magnetic susceptibility properties.
Neuroradiology, 2017 Apr, 59 (4) 403-409

Hagel C, Buslei R, Buchfelder M, Fahlbusch R, Bergmann M, Giese A, Flitsch J, Lüdecke DK, Glatzel M & Saeger W
Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells.
Pituitary, 2017 Apr, 20 (2) 211-217

Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ & Becker D
Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.
Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun 20, 114 (25) E4971-E4977

Vettermann FJ, Neumann JE, Suchorska B, Bartenstein P, Giese A, Dorostkar MM, Albert NL & Schüller U
K27M midline gliomas display malignant progression by imaging and histology.
Neuropathology and applied neurobiology, 2017 Aug, 43 (5) 458-462

Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I & Movement Disorder Society-endorsed PSP Study Group
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Movement disorders : official journal of the Movement Disorder Society, 2017 Jun, 32 (6) 853-864

Eigenbrod S, Frick P, Bertsch U, Mitteregger-Kretzschmar G, Mielke J, Maringer M, Piening N, Hepp A, Daude N, Windl O, Levin J, Giese A, Sakthivelu V, Tatzelt J, Kretzschmar H & Westaway D
Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.
PloS one, 2017, 12 (12) e0188989

Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A & Herms J
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.
EMBO molecular medicine, 2017 May, 9 (5) 716-731

2016

Neumann JE, Dorostkar MM, Korshunov A, Mawrin C, Koch A, Giese A & Schüller U
Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients.
Journal of neuropathology and experimental neurology, 2016 May, 75 (5) 408-14

Füllhase C, Schreiber A, Giese A, Schmidt M, Montorsi F, Gratzke C, La Croce G, Castiglione F, Stief C & Hedlund P
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats.
Neurourology and urodynamics, 2016 Apr, 35 (4) 464-70

Levin J, Maaß S, Schuberth M, Respondek G, Paul F, Mansmann U, Oertel WH, Lorenzl S, Krismer F, Seppi K, Poewe W, Wenning G, PROMESA study group, Giese A, Bötzel K & Höglinger G
The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach.
Journal of neural transmission (Vienna, Austria : 1996), 2016 Apr, 123 (4) 439-45

Levin J, Kurz A, Arzberger T, Giese A & Höglinger GU
The Differential Diagnosis and Treatment of Atypical Parkinsonism.
Deutsches Arzteblatt international, 2016 Feb 05, 113 (5) 61-9

Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P, Blevins J, Zhang S, Cohen Y, Chen W, Yamada M, Hamaguchi T, Sanjo N, Mizusawa H, Nakamura Y, Kitamoto T, Collins SJ, Boyd A, Will RG, Knight R, Ponto C, Zerr I, Kraus TF, Eigenbrod S, Giese A, Calero M, de Pedro-Cuesta J, Haïk S, Laplanche JL, Bouaziz-Amar E, Brandel JP, Capellari S, Parchi P, Poleggi A, Ladogana A, O'Donnell-Luria AH, Karczewski KJ, Marshall JL, Boehnke M, Laakso M, Mohlke KL, Kähler A, Chambert K, McCarroll S, Sullivan PF, Hultman CM, Purcell SM, Sklar P, van der Lee SJ, Rozemuller A, Jansen C, Hofman A, Kraaij R, van Rooij JG, Ikram MA, Uitterlinden AG, van Duijn CM, Exome Aggregation Consortium (ExAC), Daly MJ & MacArthur DG
Quantifying prion disease penetrance using large population control cohorts.
Science translational medicine, 2016 Jan 20, 8 (322) 322ra9

Cescatti M, Saverioni D, Capellari S, Tagliavini F, Kitamoto T, Ironside J, Giese A & Parchi P
Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions.
Journal of virology, 2016 Jul 15, 90 (14) 6244-6254

Kurz C, Ebersbach G, Respondek G, Giese A, Arzberger T & Höglinger GU
An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability.
Acta neuropathologica communications, 2016 Nov 14, 4 (1) 120

Levin J, Hillmer AS, Högen T, McLean PJ & Giese A
Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy.
Biochemical and biophysical research communications, 2016 Aug 12, 477 (1) 76-82

Steinacker P, Blennow K, Halbgebauer S, Shi S, Ruf V, Oeckl P, Giese A, Kuhle J, Slivarichova D, Zetterberg H & Otto M
Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease.
Scientific reports, 2016 Dec 08, 6 38737

Tatura R, Kraus T, Giese A, Arzberger T, Buchholz M, Höglinger G & Müller U
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.
Parkinsonism & related disorders, 2016 Dec, 33 115-121

Schnell O, Thorsteinsdottir J, Fleischmann DF, Lenski M, Abenhardt W, Giese A, Tonn JC, Belka C, Kreth FW & Niyazi M
Re-irradiation strategies in combination with bevacizumab for recurrent malignant glioma.
Journal of neuro-oncology, 2016 Dec, 130 (3) 591-599

Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T & Steiner H
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
EMBO molecular medicine, 2016 May, 8 (5) 458-65

Ghio S, Kamp F, Cauchi R, Giese A & Vassallo N
Interaction of α-synuclein with biomembranes in Parkinson's disease--role of cardiolipin.
Progress in lipid research, 2016 Jan, 61 73-82

Fellner L, Kuzdas-Wood D, Levin J, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK & Stefanova N
Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.
Frontiers in neuroscience, 2016, 10 99

Levin J, Maaß S, Schuberth M, Respondek G, Paul F, Mansmann U, Oertel WH, Lorenzl S, Krismer F, Seppi K, Poewe W, Wenning G, Berg D, Claßen J, Ebersbach G, Eggert K, Kassubek J, Lipp A, Löhle M, Mollenhauer B, Münchau A, Südmeyer M, Blankenstein C, Eberhardt C, Ertl-Wagner B, Heise H, Ricard I, PROMESA study group, Giese A, Bötzel K & Höglinger G
Erratum to: The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach.
Journal of neural transmission (Vienna, Austria : 1996), 2016 Nov, 123 (11) 1357-1358

2015

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A & Fuhrmann M
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta neuropathologica, 2015 Nov, 130 (5) 619-31

Wagner M, Steinbacher J, Kraus TF, Michalakis S, Hackner B, Pfaffeneder T, Perera A, Müller M, Giese A, Kretzschmar HA & Carell T
Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.
Angewandte Chemie (International ed. in English), 2015 Oct 12, 54 (42) 12511-4

Levin J, Bak TH, Rominger A, Mille E, Arzberger T, Giese A, Ackl N, Lorenzl S, Bader B, Patzig M, Bötzel K & Danek A
The association of aphasia and right-sided motor impairment in corticobasal syndrome.
Journal of neurology, 2015 Oct, 262 (10) 2241-6

Shi S, Wagner J, Mitteregger-Kretzschmar G, Ryazanov S, Leonov A, Griesinger C & Giese A
Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.
Journal of neuropathology and experimental neurology, 2015 Sep, 74 (9) 924-33

Deeg AA, Reiner AM, Schmidt F, Schueder F, Ryazanov S, Ruf VC, Giller K, Becker S, Leonov A, Griesinger C, Giese A & Zinth W
Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates.
Biochimica et biophysica acta, 2015 Sep, 1850 (9) 1884-90

Kantelhardt SR, Hausen U, Kosterhon M, Amr AN, Gruber K & Giese A
Computer simulation and image guidance for individualised dynamic spinal stabilization.
International journal of computer assisted radiology and surgery, 2015 Aug, 10 (8) 1325-32

Giese A & Arzberger T
In Memoriam: Hans A. Kretzschmar (1953–2014).
Journal of neural transmission (Vienna, Austria : 1996), 2015 Jul, 122 (7) 934-5

Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH & Schneider A
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.
Acta neuropathologica, 2015 May, 129 (5) 695-713

Thon N, Kunz M, Lemke L, Jansen NL, Eigenbrod S, Kreth S, Lutz J, Egensperger R, Giese A, Herms J, Weller M, Kretzschmar H, Tonn JC, la Fougère C & Kreth FW
Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.
International journal of cancer, 2015 May 01, 136 (9) 2132-45

Wollenweber FA, Hanecker P, Bayer-Karpinska A, Malik R, Bäzner H, Moreton F, Muir KW, Müller S, Giese A, Opherk C, Dichgans M, Haffner C & Duering M
Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro.
Stroke, 2015 Mar, 46 (3) 786-92

Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Högen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E & Kümpfel T
Histopathology and clinical course of MOG-antibody-associated encephalomyelitis.
Annals of clinical and translational neurology, 2015 Mar, 2 (3) 295-301

2014

Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F & Herms J
Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.
Translational psychiatry, 2014 Dec 16, 4 e489

Respondek G, Stamelou M, Kurz C, Ferguson LW, Rajput A, Chiu WZ, van Swieten JC, Troakes C, Al Sarraj S, Gelpi E, Gaig C, Tolosa E, Oertel WH, Giese A, Roeber S, Arzberger T, Wagenpfeil S, Höglinger GU & Movement Disorder Society-endorsed PSP Study Group
The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases.
Movement disorders : official journal of the Movement Disorder Society, 2014 Dec, 29 (14) 1758-66

Kast J, Hanecker P, Beaufort N, Giese A, Joutel A, Dichgans M, Opherk C & Haffner C
Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.
Acta neuropathologica communications, 2014 Aug 13, 2 96

Eigenbrod S, Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A & Kreth FW
Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients.
Acta neurochirurgica, 2014 Aug, 156 (8) 1427-40

Levin J, Tiedt S, Arzberger T, Biskup S, Schuberth M, Stenglein-Krapf G, Kreth FW, Högen T, la Fougère C, Linn J, van der Knaap MS, Giese A, Kretzschmar HA & Danek A
Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.
Clinical neurology and neurosurgery, 2014 Jul, 122 113-5

Levin J, Schmidt F, Boehm C, Prix C, Bötzel K, Ryazanov S, Leonov A, Griesinger C & Giese A
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.
Acta neuropathologica, 2014 May, 127 (5) 779-80

Brouwer MC, Meijers JC, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D & Koedel U
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.
Acta neuropathologica, 2014 Apr, 127 (4) 553-64

Leidel F, Eiden M, Geissen M, Hirschberger T, Tavan P, Giese A, Kretzschmar HA, Schätzl H & Groschup MH
Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.
Biochemical and biophysical research communications, 2014 Feb 28, 445 (1) 23-9

Nübling GS, Levin J, Bader B, Lorenzl S, Hillmer A, Högen T, Kamp F & Giese A
Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers.
PloS one, 2014, 9 (6) e98906

2013

Camilleri A, Zarb C, Caruana M, Ostermeier U, Ghio S, Högen T, Schmidt F, Giese A & Vassallo N
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.
Biochimica et biophysica acta, 2013 Nov, 1828 (11) 2532-43

Högen T, Demel C, Giese A, Angele B, Pfister HW, Koedel U & Klein M
Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis.
Antimicrobial agents and chemotherapy, 2013 Oct, 57 (10) 4825-30

Füllhase C, Hennenberg M, Giese A, Schmidt M, Strittmatter F, Soler R, Gratzke C, Andersson KE & Stief C
Presence of phosphodiesterase type 5 in the spinal cord and its involvement in bladder outflow obstruction related bladder overactivity.
The Journal of urology, 2013 Oct, 190 (4) 1430-5

Saverioni D, Notari S, Capellari S, Poggiolini I, Giese A, Kretzschmar HA & Parchi P
Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions.
The Journal of biological chemistry, 2013 Sep 27, 288 (39) 27972-85

Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C & Giese A
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Acta neuropathologica, 2013 Jun, 125 (6) 795-813

2012

Caruana M, Neuner J, Högen T, Schmidt F, Kamp F, Scerri C, Giese A & Vassallo N
Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro.
Biochimica et biophysica acta, 2012 Nov, 1818 (11) 2502-10

Parchi P, de Boni L, Saverioni D, Cohen ML, Ferrer I, Gambetti P, Gelpi E, Giaccone G, Hauw JJ, Höftberger R, Ironside JW, Jansen C, Kovacs GG, Rozemuller A, Seilhean D, Tagliavini F, Giese A & Kretzschmar HA
Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA.
Acta neuropathologica, 2012 Oct, 124 (4) 517-29

Nübling G, Levin J, Bader B, Israel L, Bötzel K, Lorenzl S & Giese A
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation.
Experimental neurology, 2012 Oct, 237 (2) 470-6

Fiorino F, Eiden M, Giese A, Severino B, Esposito A, Groschup MH, Perissutti E, Magli E, Incisivo GM, Ciano A, Frecentese F, Kretzschmar HA, Wagner J, Santagada V & Caliendo G
Synthesis of benzamide derivatives and their evaluation as antiprion agents.
Bioorganic & medicinal chemistry, 2012 Aug 15, 20 (16) 5001-11

Nübling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H & Giese A
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level.
Molecular neurodegeneration, 2012 Jul 23, 7 35

Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F & Giese A
Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.
Biophysical journal, 2012 Apr 04, 102 (7) 1646-55

Willhauck MJ, Pöpperl G, Rachinger W, Giese A, Auernhammer CJ & Spitzweg C
An unusual case of ectopic ACTH syndrome.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2012 Feb, 120 (2) 63-7

2011

de Boni L, Tierling S, Roeber S, Walter J, Giese A & Kretzschmar HA
Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.
Neuromolecular medicine, 2011 Dec, 13 (4) 310-20

Eigenbrod S, Roeber S, Thon N, Giese A, Krieger A, Grasbon-Frodl E, Egensperger R, Tonn JC, Kreth FW & Kretzschmar HA
α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status.
Journal of neuropathology and experimental neurology, 2011 Nov, 70 (11) 970-8

Leidel F, Eiden M, Geissen M, Kretzschmar HA, Giese A, Hirschberger T, Tavan P, Schätzl HM & Groschup MH
Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.
Antimicrobial agents and chemotherapy, 2011 Oct, 55 (10) 4774-81

Geissen M, Leidel F, Eiden M, Hirschberger T, Fast C, Bertsch U, Tavan P, Giese A, Kretzschmar H, Schatzl HM & Groschup MH
From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.
ChemMedChem, 2011 Oct 04, 6 (10) 1928-37

Duering M, Karpinska A, Rosner S, Hopfner F, Zechmeister M, Peters N, Kremmer E, Haffner C, Giese A, Dichgans M & Opherk C
Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis.
Human molecular genetics, 2011 Aug 15, 20 (16) 3256-65

Bader B, Nübling G, Mehle A, Nobile S, Kretzschmar H & Giese A
Single particle analysis of tau oligomer formation induced by metal ions and organic solvents.
Biochemical and biophysical research communications, 2011 Jul 22, 411 (1) 190-6

Hüls S, Högen T, Vassallo N, Danzer KM, Hengerer B, Giese A & Herms J
AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers.
Journal of neurochemistry, 2011 Jun, 117 (5) 868-78

Caruana M, Högen T, Levin J, Hillmer A, Giese A & Vassallo N
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds.
FEBS letters, 2011 Apr 20, 585 (8) 1113-20

Eigenbrod S, Frick P, Giese A, Schelzke G, Zerr I & Kretzschmar HA
Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity.
Journal of neuropathology and experimental neurology, 2011 Mar, 70 (3) 192-200

Demel C, Hoegen T, Giese A, Angele B, Pfister HW, Koedel U & Klein M
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
Journal of neuroinflammation, 2011 Jan 24, 8 (1) 7

Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K & Giese A
Generation of ferric iron links oxidative stress to α-synuclein oligomer formation.
Journal of Parkinson's disease, 2011, 1 (2) 205-16

Gauci AJ, Caruana M, Giese A, Scerri C & Vassallo N
Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates.
Journal of Alzheimer's disease : JAD, 2011, 27 (4) 767-79

Parchi P, Strammiello R, Giese A & Kretzschmar H
Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future.
Acta neuropathologica, 2011 Jan, 121 (1) 91-112

2010

Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF & Haass C
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
The EMBO journal, 2010 Oct 20, 29 (20) 3571-89

Parchi P, Cescatti M, Notari S, Schulz-Schaeffer WJ, Capellari S, Giese A, Zou WQ, Kretzschmar H, Ghetti B & Brown P
Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease.
Brain : a journal of neurology, 2010 Oct, 133 (10) 3030-42

Levin J, Bulst S, Thirion C, Schmidt F, Bötzel K, Krause S, Pertl C, Kretzschmar H, Walter MC, Giese A & Lochmüller H
Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy.
Journal of neuropathology and experimental neurology, 2010 Apr, 69 (4) 415-24

Levin J, Bötzel K, Giese A, Vogeser M & Lorenzl S
Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis.
Dementia and geriatric cognitive disorders, 2010, 29 (6) 553-9

Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar H, McLean PJ & Giese A
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.
Biochemical and biophysical research communications, 2010 Jan 01, 391 (1) 461-6

2009

Parchi P, Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, Zerr I, Roncaroli F, Cras P, Ghetti B, Pocchiari M, Kretzschmar H & Capellari S
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification.
Acta neuropathologica, 2009 Nov, 118 (5) 659-71

Opherk C, Duering M, Peters N, Karpinska A, Rosner S, Schneider E, Bader B, Giese A & Dichgans M
CADASIL mutations enhance spontaneous multimerization of NOTCH3.
Human molecular genetics, 2009 Aug 01, 18 (15) 2761-7

Wolschner C, Giese A, Kretzschmar HA, Huber R, Moroder L & Budisa N
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
Proceedings of the National Academy of Sciences of the United States of America, 2009 May 12, 106 (19) 7756-61

Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, Kretzschmar H & Lorenzl S
Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.
Experimental neurology, 2009 Jan, 215 (1) 201-8

2008

Notari S, Strammiello R, Capellari S, Giese A, Cescatti M, Grassi J, Ghetti B, Langeveld JP, Zou WQ, Gambetti P, Kretzschmar HA & Parchi P
Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease.
The Journal of biological chemistry, 2008 Nov 07, 283 (45) 30557-65

Weber P, Reznicek L, Mitteregger G, Kretzschmar H & Giese A
Differential effects of prion particle size on infectivity in vivo and in vitro.
Biochemical and biophysical research communications, 2008 May 09, 369 (3) 924-8

Kostka M, Högen T, Danzer KM, Levin J, Habeck M, Wirth A, Wagner R, Glabe CG, Finger S, Heinzelmann U, Garidel P, Duan W, Ross CA, Kretzschmar H & Giese A
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
The Journal of biological chemistry, 2008 Apr 18, 283 (16) 10992-1003

2007

Notari S, Capellari S, Langeveld J, Giese A, Strammiello R, Gambetti P, Kretzschmar HA & Parchi P
A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule.
Laboratory investigation; a journal of technical methods and pathology, 2007 Nov, 87 (11) 1103-12

Weber P, Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M & Kretzschmar HA
Generation of genuine prion infectivity by serial PMCA.
Veterinary microbiology, 2007 Aug 31, 123 (4) 346-57

Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B & Kostka M
Different species of alpha-synuclein oligomers induce calcium influx and seeding.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007 Aug 22, 27 (34) 9220-32

Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU & Schmid B
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model.
The Journal of biological chemistry, 2007 Mar 23, 282 (12) 9195-203

Wagner I, Sethi S, Xiang W, Giese A, Ebner S & Kretzschmar H
Repeated peripheral administrations of CpG oligodeoxynucleotides lead to sustained CNS immune activation.
Immunopharmacology and immunotoxicology, 2007, 29 (3-4) 413-24

2006

Weber P, Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M & Kretzschmar HA
Cell-free formation of misfolded prion protein with authentic prion infectivity.
Proceedings of the National Academy of Sciences of the United States of America, 2006 Oct 24, 103 (43) 15818-23

Behrends C, Langer CA, Boteva R, Böttcher UM, Stemp MJ, Schaffar G, Rao BV, Giese A, Kretzschmar H, Siegers K & Hartl FU
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.
Molecular cell, 2006 Sep 15, 23 (6) 887-97

Piening N, Weber P, Högen T, Beekes M, Kretzschmar H & Giese A
Photo-induced crosslinking of prion protein oligomers and prions.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2006 Jun, 13 (2) 67-77

Barnewitz K, Maringer M, Mitteregger G, Giese A, Bertsch U & Kretzschmar HA
Unaltered prion protein cleavage in plasminogen-deficient mice.
Neuroreport, 2006 Apr 03, 17 (5) 527-30

2005

Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C & Kretzschmar H
Single particle detection and characterization of synuclein co-aggregation.
Biochemical and biophysical research communications, 2005 Aug 12, 333 (4) 1202-10

Sarafoff NI, Bieschke J, Giese A, Weber P, Bertsch U & Kretzschmar HA
Automated PrPres amplification using indirect sonication.
Journal of biochemical and biophysical methods, 2005 Jun 30, 63 (3) 213-21

Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Tatzelt J, Kretzschmar HA & Giese A
Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.
Journal of virology, 2005 Jun, 79 (12) 7785-91

Levin J, Bertsch U, Kretzschmar H & Giese A
Single particle analysis of manganese-induced prion protein aggregates.
Biochemical and biophysical research communications, 2005 Apr 22, 329 (4) 1200-7

Stork M, Giese A, Kretzschmar HA & Tavan P
Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln.
Biophysical journal, 2005 Apr, 88 (4) 2442-51

Piening N, Weber P, Giese A & Kretzschmar H
Breakage of PrP aggregates is essential for efficient autocatalytic propagation of misfolded prion protein.
Biochemical and biophysical research communications, 2005 Jan 14, 326 (2) 339-43

Giese A, Buchholz M, Herms J & Kretzschmar HA
Mouse brain synaptosomes accumulate copper-67 efficiently by two distinct processes independent of cellular prion protein.
Journal of molecular neuroscience : MN, 2005, 27 (3) 347-54

2004

Bieschke J, Weber P, Sarafoff N, Beekes M, Giese A & Kretzschmar H
Autocatalytic self-propagation of misfolded prion protein.
Proceedings of the National Academy of Sciences of the United States of America, 2004 Aug 17, 101 (33) 12207-11

Giese A, Levin J, Bertsch U & Kretzschmar H
Effect of metal ions on de novo aggregation of full-length prion protein.
Biochemical and biophysical research communications, 2004 Aug 06, 320 (4) 1240-6

Notari S, Capellari S, Giese A, Westner I, Baruzzi A, Ghetti B, Gambetti P, Kretzschmar HA & Parchi P
Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.
The Journal of biological chemistry, 2004 Apr 16, 279 (16) 16797-804

2001

Dürig J, Giese A, Schmücker U, Kretzschmar HA & Dührsen U
Decreased prion protein expression in human peripheral blood leucocytes from patients with paroxysmal nocturnal haemoglobinuria.
British journal of haematology, 2001 Mar, 112 (3) 658-62

Kretzschmar HA, Tings T, Madlung A, Giese A & Herms J
Prion protein as copper-binding protein at the synapse.
Methods in molecular medicine, 2001, 59 17-30

Giese A & Kretzschmar HA
Prion-induced neuronal damage--the mechanisms of neuronal destruction in the subacute spongiform encephalopathies.
Current topics in microbiology and immunology, 2001, 253 203-17

2000

Zerr I, Schulz-Schaeffer WJ, Giese A, Bodemer M, Schröter A, Henkel K, Tschampa HJ, Windl O, Pfahlberg A, Steinhoff BJ, Gefeller O, Kretzschmar HA & Poser S
Current clinical diagnosis in Creutzfeldt-Jakob disease: identification of uncommon variants.
Annals of neurology, 2000 Sep, 48 (3) 323-9

Bieschke J, Giese A, Schulz-Schaeffer W, Zerr I, Poser S, Eigen M & Kretzschmar H
Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets.
Proceedings of the National Academy of Sciences of the United States of America, 2000 May 09, 97 (10) 5468-73

Dürig J, Giese A, Schulz-Schaeffer W, Rosenthal C, Schmücker U, Bieschke J, Dührsen U & Kretzschmar HA
Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.
British journal of haematology, 2000 Mar, 108 (3) 488-95

Giese A, Bieschke J, Eigen M & Kretzschmar HA
Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases.
Archives of virology. Supplementum, 2000, (16) 161-71

Kretzschmar HA, Tings T, Madlung A, Giese A & Herms J
Function of PrP(C) as a copper-binding protein at the synapse.
Archives of virology. Supplementum, 2000, (16) 239-49

Poser S, Zerr I, Schroeter A, Otto M, Giese A, Steinhoff BJ & Kretzschmar HA
Clinical and differential diagnosis of Creutzfeldt-Jakob disease.
Archives of virology. Supplementum, 2000, (16) 153-9

Schulz-Schaeffer WJ, Tschöke S, Kranefuss N, Dröse W, Hause-Reitner D, Giese A, Groschup MH & Kretzschmar HA
The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases.
The American journal of pathology, 2000 Jan, 156 (1) 51-6

1999

Skworc KH, Windl O, Schulz-Schaeffer WJ, Giese A, Bergk J, Nägele A, Vieregge P, Zerr I, Poser S & Kretzschmar HA
Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene.
Annals of neurology, 1999 Nov, 46 (5) 693-700

Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, Schürmann P, Windl O, Brose N & Kretzschmar H
Evidence of presynaptic location and function of the prion protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999 Oct 15, 19 (20) 8866-75

Windl O, Giese A, Schulz-Schaeffer W, Zerr I, Skworc K, Arendt S, Oberdieck C, Bodemer M, Poser S & Kretzschmar HA
Molecular genetics of human prion diseases in Germany.
Human genetics, 1999 Sep, 105 (3) 244-52

Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Zerr I, Budka H, Kopp N, Piccardo P, Poser S, Rojiani A, Streichemberger N, Julien J, Vital C, Ghetti B, Gambetti P & Kretzschmar H
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.
Annals of neurology, 1999 Aug, 46 (2) 224-33

1998

Zerr I, Giese A, Windl O, Kropp S, Schulz-Schaeffer W, Riedemann C, Skworc K, Bodemer M, Kretzschmar HA & Poser S
Phenotypic variability in fatal familial insomnia (D178N-129M) genotype.
Neurology, 1998 Nov, 51 (5) 1398-405

Kretzschmar H, Giese A, Zerr I, Windl O, Schulz-Schaeffer W, Skworc K & Poser S
The German FFI cases.
Brain pathology (Zurich, Switzerland), 1998 Jul, 8 (3) 559-61

Giese A, Brown DR, Groschup MH, Feldmann C, Haist I & Kretzschmar HA
Role of microglia in neuronal cell death in prion disease.
Brain pathology (Zurich, Switzerland), 1998 Jul, 8 (3) 449-57

von zur Mühlen F, Klass C, Kreuzer H, Mall G, Giese A & Reimers CD
Cardiac involvement in proximal myotonic myopathy.
Heart (British Cardiac Society), 1998 Jun, 79 (6) 619-21

Otto M, Wiltfang J, Schütz E, Zerr I, Otto A, Pfahlberg A, Gefeller O, Uhr M, Giese A, Weber T, Kretzschmar HA & Poser S
Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study.
BMJ (Clinical research ed.), 1998 Feb 21, 316 (7131) 577-82

1997

Parchi P, Capellari S, Chen SG, Petersen RB, Gambetti P, Kopp N, Brown P, Kitamoto T, Tateishi J, Giese A & Kretzschmar H
Typing prion isoforms.
Nature, 1997 Mar 20, 386 (6622) 232-4

Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B & Groschup M
Cell death in prion disease.
Journal of neural transmission. Supplementum, 1997, 50 191-210

Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D & Kretzschmar H
The cellular prion protein binds copper in vivo.
Nature, 1997, 390 (6661) 684-7

Schallock K, Schulz-Schaeffer WJ, Giese A & Kretzschmar HA
Postmortem delay and temperature conditions affect the in situ end-labeling (ISEL) assay in brain tissue of mice.
Clinical neuropathology, 1997, 16 (3) 133-6

1996

Schulz-Schaeffer WJ, Giese A, Windl O & Kretzschmar HA
Polymorphism at codon 129 of the prion protein gene determines cerebellar pathology in Creutzfeldt-Jakob disease.
Clinical neuropathology, 1996, 15 (6) 353-7

1995

Giese A, Groschup MH, Hess B & Kretzschmar HA
Neuronal cell death in scrapie-infected mice is due to apoptosis.
Brain pathology (Zurich, Switzerland), 1995 Jul, 5 (3) 213-21