Zentrum für Neuropathologie und Prionforschung
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Carmelo Sgobio, PhD

[2019] [2017] [2016] [2015] [2014] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004]

2019

Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C & Herms J
In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.
Glia, 2019 Jan 22

2017

Dunn AR, Stout KA, Ozawa M, Lohr KM, Hoffman CA, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM & Miller GW
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America, 2017 Mar 14, 114 (11) E2253-E2262

Sgobio C, Wu J, Zheng W, Chen X, Pan J, Salinas AG, Davis MI, Lovinger DM & Cai H
Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.
Scientific reports, 2017 Jul 13, 7 (1) 5283

2016

Xu J, Wu XS, Sheng J, Zhang Z, Yue HY, Sun L, Sgobio C, Lin X, Peng S, Jin Y, Gan L, Cai H & Wu LG
α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016 Apr 20, 36 (16) 4408-14

Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC & Herms J
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.
The EMBO journal, 2016 Oct 17, 35 (20) 2213-2222

2015

Liu G, Sgobio C, Gu X, Sun L, Lin X, Yu J, Parisiadou L, Xie C, Sastry N, Ding J, Lohr KM, Miller GW, Mateo Y, Lovinger DM & Cai H
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Human molecular genetics, 2015 Sep 15, 24 (18) 5299-312

Sastry N, Zheng W, Liu G, Wang H, Chen X, Cai M, Contractor P, Sgobio C, Sun L, Xie C & Cai H
No apparent transmission of transgenic α-synuclein into nigrostriatal dopaminergic neurons in multiple mouse models.
Translational neurodegeneration, 2015, 4 23

2014

Pendolino V, Bagetta V, Ghiglieri V, Sgobio C, Morelli E, Poggini S, Branchi I, Latagliata EC, Pascucci T, Puglisi-Allegra S, Calabresi P & Picconi B
l-DOPA reverses the impairment of Dentate Gyrus LTD in experimental parkinsonism via β-adrenergic receptors.
Experimental neurology, 2014 Nov, 261 377-85

Parisiadou L, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM & Cai H
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
Nature neuroscience, 2014 Mar, 17 (3) 367-76

2012

Bagetta V, Sgobio C, Pendolino V, Del Papa G, Tozzi A, Ghiglieri V, Giampà C, Zianni E, Gardoni F, Calabresi P & Picconi B
Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012 Dec 05, 32 (49) 17921-31

Gardoni F, Sgobio C, Pendolino V, Calabresi P, Di Luca M & Picconi B
Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias.
Neurobiology of aging, 2012 Sep, 33 (9) 2138-44

Ghiglieri V, Pendolino V, Sgobio C, Bagetta V, Picconi B & Calabresi P
Θ-burst stimulation and striatal plasticity in experimental parkinsonism.
Experimental neurology, 2012 Aug, 236 (2) 395-8

Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D & Cai H
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012 Jul 04, 32 (27) 9248-64

Costa C, Sgobio C, Siliquini S, Tozzi A, Tantucci M, Ghiglieri V, Di Filippo M, Pendolino V, de Iure A, Marti M, Morari M, Spillantini MG, Latagliata EC, Pascucci T, Puglisi-Allegra S, Gardoni F, Di Luca M, Picconi B & Calabresi P
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.
Brain : a journal of neurology, 2012 Jun, 135 (Pt 6) 1884-99

Trabalza A, Colazingari S, Sgobio C & Bevilacqua A
Contextual learning increases dendrite complexity and EphrinB2 levels in hippocampal mouse neurons.
Behavioural brain research, 2012 Feb 01, 227 (1) 175-83

2011

Bagetta V, Picconi B, Marinucci S, Sgobio C, Pendolino V, Ghiglieri V, Fusco FR, Giampà C & Calabresi P
Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Aug 31, 31 (35) 12513-22

Ghiglieri V, Sgobio C, Costa C, Picconi B & Calabresi P
Striatum-hippocampus balance: from physiological behavior to interneuronal pathology.
Progress in neurobiology, 2011 Jul, 94 (2) 102-14

Spalloni A, Origlia N, Sgobio C, Trabalza A, Nutini M, Berretta N, Bernardi G, Domenici L, Ammassari-Teule M & Longone P
Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alphaCaMKII at threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1G93A mice, a murine model for amyotrophic lateral sclerosis.
Cerebral cortex (New York, N.Y. : 1991), 2011 Apr, 21 (4) 796-805

D'Amato FR, Zanettini C, Sgobio C, Sarli C, Carone V, Moles A & Ammassari-Teule M
Intensification of maternal care by double-mothering boosts cognitive function and hippocampal morphology in the adult offspring.
Hippocampus, 2011 Mar, 21 (3) 298-308

Picconi B, Bagetta V, Ghiglieri V, Paillè V, Di Filippo M, Pendolino V, Tozzi A, Giampà C, Fusco FR, Sgobio C & Calabresi P
Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia.
Brain : a journal of neurology, 2011 Feb, 134 (Pt 2) 375-87

2010

Ghiglieri V, Pendolino V, Bagetta V, Sgobio C, Calabresi P & Picconi B
mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP.
Experimental neurology, 2010 Dec, 226 (2) 328-31

Paillé V, Picconi B, Bagetta V, Ghiglieri V, Sgobio C, Di Filippo M, Viscomi MT, Giampà C, Fusco FR, Gardoni F, Bernardi G, Greengard P, Di Luca M & Calabresi P
Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010 Oct 20, 30 (42) 14182-93

Ghiglieri V, Sgobio C, Patassini S, Bagetta V, Fejtova A, Giampà C, Marinucci S, Heyden A, Gundelfinger ED, Fusco FR, Calabresi P & Picconi B
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010 Jun, 35 (7) 1531-40

Bagetta V, Ghiglieri V, Sgobio C, Calabresi P & Picconi B
Synaptic dysfunction in Parkinson's disease.
Biochemical Society transactions, 2010 Apr, 38 (2) 493-7

Sgobio C, Ghiglieri V, Costa C, Bagetta V, Siliquini S, Barone I, Di Filippo M, Gardoni F, Gundelfinger ED, Di Luca M, Picconi B & Calabresi P
Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment.
Biological psychiatry, 2010 Mar 15, 67 (6) 567-74

2009

Ammassari-Teule M, Sgobio C, Biamonte F, Marrone C, Mercuri NB & Keller F
Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors.
Psychopharmacology, 2009 Jun, 204 (3) 511-21

Ghiglieri V, Picconi B, Sgobio C, Bagetta V, Barone I, Paillè V, Di Filippo M, Polli F, Gardoni F, Altrock W, Gundelfinger ED, De Sarro G, Bernardi G, Ammassari-Teule M, Di Luca M & Calabresi P
Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice.
The European journal of neuroscience, 2009 May, 29 (10) 1979-93

Di Filippo M, Picconi B, Tantucci M, Ghiglieri V, Bagetta V, Sgobio C, Tozzi A, Parnetti L & Calabresi P
Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory.
Behavioural brain research, 2009 Apr 12, 199 (1) 108-18

2008

Bagetta V, Barone I, Ghiglieri V, Di Filippo M, Sgobio C, Bernardi G, Calabresi P & Picconi B
Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.
Neuropharmacology, 2008 Aug, 55 (2) 223-9

Sgobio C, Trabalza A, Spalloni A, Zona C, Carunchio I, Longone P & Ammassari-Teule M
Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS.
Genes, brain, and behavior, 2008 Jun, 7 (4) 427-34

Picconi B, Ghiglieri V, Bagetta V, Barone I, Sgobio C & Calabresi P
Striatal synaptic changes in experimental parkinsonism: role of NMDA receptor trafficking in PSD.
Parkinsonism & related disorders, 2008, 14 Suppl 2 S145-9

2007

Middei S, Vetere G, Sgobio C & Ammassari-Teule M
Landmark-based but not vestibular-based orientation elicits mossy fiber synaptogenesis in the mouse hippocampus.
Neurobiology of learning and memory, 2007 Feb, 87 (2) 174-80

2006

Marrone MC, Marinelli S, Biamonte F, Keller F, Sgobio CA, Ammassari-Teule M, Bernardi G & Mercuri NB
Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice.
The European journal of neuroscience, 2006 Oct, 24 (7) 2061-70

Picconi B, Passino E, Sgobio C, Bonsi P, Barone I, Ghiglieri V, Pisani A, Bernardi G, Ammassari-Teule M & Calabresi P
Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.
Neurobiology of disease, 2006 Apr, 22 (1) 143-52

Spalloni A, Geracitano R, Berretta N, Sgobio C, Bernardi G, Mercuri NB, Longone P & Ammassari-Teule M
Molecular and synaptic changes in the hippocampus underlying superior spatial abilities in pre-symptomatic G93A+/+ mice overexpressing the human Cu/Zn superoxide dismutase (Gly93 --> ALA) mutation.
Experimental neurology, 2006 Feb, 197 (2) 505-14

2005

Restivo L, Ferrari F, Passino E, Sgobio C, Bock J, Oostra BA, Bagni C & Ammassari-Teule M
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.
Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 09, 102 (32) 11557-62

2004