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2017

Dietrich O, Levin J, Ahmadi SA, Plate A, Reiser MF, Bötzel K, Giese A, & Ertl-Wagner B (2017)
MR imaging differentiation of Fe2+ and Fe3+ based on relaxation and magnetic susceptibility properties.
Neuroradiology. [Epub ahead of print]
Dietrich O, Levin J, Ahmadi SA, Plate A, Reiser MF, Bötzel K, Giese A, & Ertl-Wagner B (2017)
MR imaging differentiation of Fe2+ and Fe3+ based on relaxation and magnetic susceptibility properties.
Neuroradiology. 2017 Apr;59(4):403-409. doi: 10.1007/s00234-017-1813-3
Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, & Edbauer D (2017)
Pathomechanisms and clinical aspects of frontotemporal lobar degeneration.
Nervenarzt..88(2):163-172.
Bruch J, Xu H, Rösler TW, De Andrade A, Kuhn PH, Lichtenthaler SF, Arzberger T, Winklhofer KF, Müller U, & Höglinger GU (2017)
PERK activation mitigates tau pathology in vitro and in vivo.
EMBO.9(3):371-384
Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A, & Herms J (2017)
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex
EMBO Mol Med. 9(5):716-731
Zhu K, Xiang X, Filser S, Marinkovic P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Herms J, & Gunnersen JM (2017)
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
Biol Psychiatry. [Epub ahead of print],
Blazquez-Llorca L, Valero-Freitag S, Rodrigues EF, Merchán-Pérez Á, Rodríguez JR, Dorostkar MM, DeFelipe J, & Herms J (2017)
High plasticity of axonal pathology in Alzheimer's disease mouse models.
Acta Neuropathol Commun.5(1):14.
Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, Deussing JM, & Herms J (2017)
Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD).
Neuropharmacology. [Epub ahead of print]
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Herms J, Haass C, & Rominger A (2017)
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
Front Aging Neurosci.9:8
Nübling G, Schuberth M, Feldmer K, Giese A, Holdt LM, Teupser D, & Lorenzl S (2017)
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Exp Brain Res. 2017 May 10. doi: 10.1007/s00221-017-4978-4
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, & Movement Disorder Society-endorsed PSP Study Group (2017)
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Mov Disord. 2017 May 3. doi: 10.1002/mds.26987. [Epub ahead of print]
Schön C, & Herms J (2017)
In Vivo Imaging of Tau Aggregates in the Mouse Retina
Methods Mol Biol. 1523:361-368
Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, & Becker D (2017)
Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.
Proc Natl Acad Sci U S A. 2017 Jun 5. pii: 201700200. doi: 10.1073/pnas.1700200114. [Epub ahead of print]
Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Höglinger GU, & Movement Disorder Society-Endorsed PSP Study Group (2017)
Which ante mortem clinical features predict progressive supranuclear palsy pathology?
Mov Disord. 2017 May 13. doi: 10.1002/mds.27034.
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2016

Kunz M, Nachbichler SB, Ertl L, Fesl G, Egensperger R, Niyazi M, Schmidt I, Tonn JC, Peraud A, & Kreth FW (2016)
Early treatment of complex located pediatric low-grade gliomas using iodine-125 brachytherapy alone or in combination with microsurgery.
Cancer Med.5(3):442-53
Levin J, Hillmer AS, Högen T, McLean PJ, & Giese A (2016)
Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy.
Biochem Biophys Res Commun. 2016 Aug 12;477(1):76-82. doi: 10.1016/j.bbrc.2016.06.023.
Cescatti M, Saverioni D, Capellari S, Tagliavini F, Kitamoto T, Ironside J, Giese A, & Parchi P (2016)
Analysis of conformational stability of abnormal prion protein aggregates across the spectrum of Creutzfeldt-Jakob disease prions.
J Virol. 90(14):6244-54
Kurz C, Ebersbach G, Respondek G, Giese A, Arzberger T, & Höglinger GU (2016)
An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability.
Acta Neuropathol Commun. 2016 Nov 14;4(1):120
Ovsepian SV, Blazquez-Llorca L, Freitag SV, & Herms J (2016)
Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors
Cereb Cortex. [Epub ahead of print]
Herms J, & Dorostkar MM (2016)
Dendritic Spine Pathology in Neurodegenerative Diseases
Annu Rev Pathol., 11:221-50
Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LPC, Gambetti P, Blevins J, Zhang S, Cohen Y, Chen W, Yamada M, Hamaguchi T, Sanjo N, Mizusawa H, Nakamura Y, Kitamoto T, Collins SJ, Boyd A, Will RG, Knight R, Ponto C, Zerr I, Eigenbrod S, Giese A, Calero M, de Pedro-Cuesta J, Haik S, Laplanche J-L, Bouaziz-Amar E, Brandel J-P, Capellari S, Parchi P, Poleggi A, Ladogana A, O'Donnell-Luria AH, Karczewski KJ, Marshall JL, Boehnke M, Laakso M, Mohlke KL, Kähler A, Chambert K, McCarroll S, Sullivan PF, Hultman CM, Purcell SM, Sklar P, van de Lee SJ, Rozemuller A, Jansen C, Hofman A, Kraaij R, van Rooij JGJ, Ikram MA, Uitterlinden AG, van Duijn CM, Exome Aggregation Consortium (ExAC), Daly MJ, & MacArthur DG (2016)
Quantifying prion disease penetrance using large population control cohorts.
Science Translational Medicine 20 Jan 2016: Vol. 8, Issue 322, pp. 322ra9; DOI: 10.1126/scitranslmed.aad5169
Schnell O, Thorsteinsdottir J, Fleischmann DF, Lenski M, Abenhardt W, Giese A, Tonn JC, Belka C, Kreth FW, & Niyazi M (2016)
Re-irradiation strategies in combination with bevacizumab for recurrent malignant glioma.
J Neurooncol. 2016 Dec;130(3):591-599.
Levin J, Maaß S, Schuberth M, Respondek G, Paul F, Mansmann U, Oertel WH, Lorenzl S, Krismer F, Seppi K, Poewe W, Wenning G, PROMESA study group, Giese A, Bötzel K, & Höglinger G (2016)
The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach.
J Neural Transm (Vienna). 2016 Apr;123(4):439-45. doi: 10.1007/s00702-016-1507-8.
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, & Steiner H (2016)
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
EMBO Mol Med. 2016 May 2;8(5):458-65. doi: 10.15252/emmm.201505952.
Müller SH, Girard SL, Hopfner F, Merner ND, Bourassa CV, Lorenz D, Clark LN, Tittmann L, Soto-Ortolaza Al, Klebe S, Hallett M, Schneider SA, Hodgkinson CA, Lieb W, Wszolek ZK, Pendziwiat M, Lorenzo-Betancor O, Poewe W, Ortega-Cubero S, Seppi K, Rajput A, Hussl A, Rajput AH, Berg D, Dion PA, Wurster I, Shulman JM, Srulijes K, Haubenberger D, Pastor P, Vilarino-Güeli C, Postuma RB, Bernard G, Ladwig KH, Dunre N, Jankovic J, Strauch K, Panisset M, Winkelmann J, Testa CM, Reischl E, Zeuner KE, Ross OA, Arzberger T, Choinard S, Deuschl G, Louis ED, Kuhlenbäumer G, & Rouleau GA (2016)
Genome-wide association study in essential tremor identifies three new loci.
Brain. 2016139(Pt 12):3163-3169.
Hagel C, Buslei R, Buchfelder M, Fahlbusch R, Bergmann M, Giese A, Flitsch J, Lüdecke DK, Glatzel M, & Saeger W (2016)
Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells.
Pituitary. 2016 Oct 15.
Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DT, Capper D, Sill M, Buchhalter I, Northcott P, Leis I, Ryzhova M, Pfaff E, Allen SJ, Balasubramanian G, Worst B, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Philips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lotsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, Von Beuren AO, Von Hoff K, Rutkowski S, Herold-Mende C, Fruhwald MC, Milde T, Hasselblatt M, Wesseling P, Rossler J, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, Van Meter T, Monoranu C, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, Von Deimling A, Pfister SM, Ellison DW, Korshunov A, & Kool M (2016)
New brain tumour entities emerge from molecular classification of CNS-PNETs
Cell 164, 1060–1072
Romagna A, Schwartz C, Egensperger R, Watson J, Tonn JC, Belka C, Kreth FW, & Nachbichler SB (2016)
Iodine-125 brachytherapy as upfront and salvage treatment for brain metastases : A comparative analysis.
Strahlenther Onkol.192(11):780-788
Vettermann FJ, Neumann JE, Suchorska B, Bartenstein P, Giese A, Dorostkar MM, Albert NL, & Schüller U (2016)
K27M midline gliomas display malignant progression by imaging and histology.
Neuropathol Appl Neurobiol. 2016 Dec 20. doi: 10.1111/nan.12371.
Steinacker P, Blennow K, Halbgebauer S, Shi S, Ruf V, Oeckl P, Giese A, Kuhle J, Silvarichova D, Zetterberg H, & Otto M (2016)
Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease.
Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737
Levin J, Kurz A, Arzberger T, Giese A, & Höglinger GU (2016)
The Differential Diagnosis and Treatment of Atypical Parkinsonism.
Dtsch Arztebl Int. 2016 Feb 5;113(5):61-9. doi: 10.3238/arztebl.2016.0061.
Tatura R, Kraus T, Giese A, Arzberger T, Buchholz M, Höglinger G, & Müller U (2016)
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.
Parkinsonism Relat Disord. 2016 Dec;33:115-121. doi: 10.1016/j.parkreldis.2016.09.028.
Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim S-K, Lee J-Y, Nageswara Rao AA, Giannini C, Li KKW, Ng H-K, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DCY, Seow WT, Chang KTE, Mora J, Pollack IF, Hamilton RL, Leary S, Ermoian RP, Moore A, Ingram W, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Jung S, Jang W-Y, French PJ, Kros JM, van Veelen M-LC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Garzia L, Shih DJH, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DTW, Chan JA, Nikolic A, Garre ML, van Meir EG, Osuka S, Olson JJ, Jahangiri A, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins C E, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, & Taylor MD (2016)
Prognostic Value of Medulloblastoma Extent of Resection after Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis
Lancet Oncol 2016; in press.
Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DTW, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, Bens S, Gröschel S, Kratochwil F, Wittmann A, Sieber L, Geörg Ch, Wolf S, Beck K, Oyen F, Capper D, Van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik AE, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Mora J, Jabado N, Taylor MD, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schneppenheim R, Northcott PA, Siebert R, Frühwald MC, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister SM, & Kool M (2016)
Atypical teratoid / rhabdoid tumors (ATRT) are comprised of three epigenetic subgroups with distinct enhancer landscapes.
Cancer Cell, 29:1-15
Seystahl K, Stöcklein V., Rushing E, Nicolas G, Schäfer N, Ilhan H, Pangalu A, Weller M, Tonn J., Sommerauer M, & Albert N (2016)
Somatostatin-receptor-targeted radionuclide therapy for progressive meningioma - benefit linked to 68Ga-DOTATATE/-TOC uptake
Neuro Oncol, in press.
Neumann JE, Dorostkar MM, Korshunov A, Mawrin C, Koch A, & Giese A (2016)
Distinct Histomorphology in Molecular Subgroups of Glioblastoma in Young Patients
J Neuropathol Exp Neurol. 2016 May;75(5):408-14. doi: 10.1093/jnen/nlw015.
Overhoff F, Brendel M, Jaworska A, Korzhova V, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, & Rominger A (2016)
Automated Spatial Brain Normalization and Hindbrain White Matter Refence Tissue Give Improved [18F]-Florbetaben PET Quantitation in Alzheimer’s Model Mice
J Nucl Med, 10:45
Büchel G, Schulte J, Batzke K, Hansen W, Galluzzi L, & Schramm A (2016)
Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma.
OncoImmunology, in press
Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, & Rominger A (2016)
Small-Animal PET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models
J Nucl Med, 57(5):792-8
Schön C, Asteriti S, Koch S, Sothhilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, & Michalakis S (2016)
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia
Hum Mol Genet, 25(6):1165-75
Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger K, Haass C, Herms J, & Rominger A (2016)
Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple Tracer PET Study.
J Nucl Med, 57(6):954-60
Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Hipp A, Auweter S, Habbel C, Bamberg F, Ertl-Wagner B, Reiser M, Pfeiffer F, & Saam T (2016)
AHA Classification of Coronary and Carotid Atherosclerotic Plaque by Grating-Based Phase-Contrast Computed Tomography
Eur Radiol, in press
Fellner L, Kuzdas-Wood D, Levin J, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, & Stefanova N (2016)
Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.
Front Neurosci. 2016 Mar 10;10:99. doi: 10.3389/fnins.2016.00099.
Morrissy S, Garzia L, Shih D, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli F, Ramaswamy V, Lindsay P, Jelveh S, Donovan L, Wang X, Luu B, Zayne K, Li Y, Mungall K, Mayoh C, Thiessen N, Mercier E, Ma Y, Tse K, Zeng T, Shumansky K, Roth A, Shah S, Farooq H, Holgado B, Lee J, Matan-Lithwick S, Qin L, Reimand J, Rolider A, Liu J, Thompson Y, Wu X, Mack S, Manno A, Michealraj K, Nor C, Peacock J, Pugh T, Ally A, Bilenky M, Butterfield Y, Carlsen R, Cheng Y, Li H, Long W, Mayo M, Plettner P, Qian J, Schein J, Tam A, Wong T, Birol I, Zhao Y, Chuah E, Corbett R, Dhalla N, He A, Lee D, Faria C, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack I, Hamilton R, Li X, Bendel A, Fults D, Walter A, Kumabe T, Tominaga T, Collins V, Cho Y, Hoffman C, Lyden D, Wisoff J, Garvin J, Stearns D, Massimi L, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn S, Tirapelli D, Carlotti C, Wheeler H, Hallahan A, Ingram W, MacDonald T, Olson J, Van Meir E, Lee J, Wang K, Kim S, Cho B, Pietsch T, Fleischhack G, Tippelt S, Ra Y, Bailey S, Clifford S, Lindsey J, Eberhart C, Cooper M, Packer R, Massimino M, Garre M, Bartels U, Tabori U, Hawkins C, Dirks P, Rutka J, Bouffet E, Wechsler-Reya R, Weiss W, Collier L, Dupuy A, Korshunov A, Jones D, Kool M, Northcott P, Pfister S, Largaespada A, Mungall A, Moore R, Jabadao N, Bader G, Jones S, Malkin D, Marra M, & Taylor M (2016)
Divergent Clonal Selection Dominates Medulloblastoma at Recurrence.
Nature, 529:351-357.
Wefers A, Lindner S, & Schulte J (2016)
Overexpression of Lin28B in neural stem cells is insufficient for brain tumor formation, but induces pathological lobulation of the developing cerebellum
The Cerebellum, in press
Li L, Picotte K, Wang J, Lun M, Lidov H, Calicchio M, Zeng E, Salisbury J, Wechsler-Reya R, Lehtinen M, & Zhao H (2016)
Notch and Sonic Hedgehog converge on primary cilium in choroid plexus tumor
Nat Cell Biol, 18(4):418-30
Korshunov A., Capper D, Reuss D, Schrimpf D, Ryzhova M, Hovestadt V, Sturm D, Meyer J, Jones C, Zheludkova O, Kumirova E, Golanov A, Kool M., Mittelbronn M, Hasselblatt M, Schittenhelm J, Reifenberger G, Herold-Mende C, Lichter P., von Deimling A., Pfister S, & Jones D. (2016)
Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity
Acta Neuropathol, 131:137-146.
Sahm F, Schrimpf D, Jones D., Meyer J, Kratz A, Reuss D, Koelsche C, Korshunov A., Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M., Hummel M, Bewerunge-Hudler M, Mawrin C, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister S, Wick W, & von Deimling A. (2016)
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
Acta Neuropathol, in press
Sahm F, Jakobiec F, Meyer J, Schrimpf D, Eberhart C, Hovestadt V, Capper D, Jones D., Ryzhova M, Zheludkova O, Kumirova E, Lichter P, von Deimling A., Pfister S, Kool M., & Korshunov A. (2016)
Somatic mutations of DICER1 and KMT2D genes are frequent in intraocular medulloepitheliomas
Genes Chromosomes Cancer, 55(5):418-427
Albrecht V, Richter A, Pfeiffer S, Lindner S, Gieser E, Schichor C, Gildehaus F, Bartenstein P, Tonn J, Skerra A, & Glaß R (2016)
Anticalins directed against the fibronectin extra domain B (ED-B) as diagnostic tracers for glioblastomas
Int J Cancer, 138:1269-1280
Unterrainer M, Schweisthal F, Suchorska B, Wenter V, Schmid-Tannwald C, Fendler W, Bartenstein P, Tonn J, & Albert N (2016)
Serial 18F-FET PET imaging of primarily 18F-FET-negative glioma – does it make sense?
J Nucl Med, in press
Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, Zeinieh M, Blanc R, Burk D, Fahiminiya S, Bareke E, Monoranu C, Sträter R, Kerl K, Nierderstadt T, Kurlemann G, Ellezam B, Michalak S, Thom M, Lockhart P, Leventer R, Ohm M, MacGregor D, Jones D, Kramchandani J, Greenwood C, Berghuis A, Bens S, Siebert R, Zakrzewska M, Liberski P, Zakrzewski K, Sisodiya S, Paulus W, Albrecht S, Hasselblatt M, Jabado N, Foulkes W, & Majewski J (2016)
Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors
Acta Neuropathol, in press
Shi Y, Dorostkar MM, & Herms J (2016)
Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease
Acta Neuropathol, 131(2):235-46
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2015

Greiner A, Guibourt V, & Kretzschmar HA (2015)
Identification of Stably Expressed lncRNAs as Valid Endogenous Controls for Profiling of Human Glioma.
J Cancer. 2015 Jan 1;6(2):111-9. doi: 10.7150/jca.10867. eCollection 2015.
Kolck G, Greiner A, Schierl K, Guibourt V, & Kretzschmar HA (2015)
Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.
Tumour Biol. 2015 May 29. [Epub ahead of print]
Stieglitz M, Guibourt V, & Kretzschmar HA (2015)
Profiling of methylation and demethylation pathways during brain development and ageing.
J Neural Transm. 2015 Oct 26. [Epub ahead of print]
Blazquez-Llorca L, Hummel E, Zimmerman H, Burgold S, Rietdorf J, & Herms J (2015)
Correlation of two-photon in vivo imaging and FIB/SEM microscopy
J Microsc. 259(2):129-36
Reulen HJ, Poepperl G, Goetz C, Gildehaus FJ, Schmidt M, Tatsch K, Pietsch T, & Rachinger W (2015)
Long-term outcome of patients with WHO Grade III and IV gliomas treated by fractionated intracavitary radioimmunotherapy.
J Neurosurg. 2015 Jul 3:1-11. [Epub ahead of print]
Jung CK, Keppler K, Steinbach S, Blazquez-Llorca L, & Herms J (2015)
Fibrillar amyloid plaque formation precedes microglial activation
PLoS ONE. 10(3):e0119768
Montagna E, Shi Y, Peters F, Blazquez-Llorca L, Filser S, Shi S, Dorostkar MM, & Herms J (2015)
Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease
Acta Neuropathol. 129(6):909-20
Shi S, Wagner J, Mitteregger-Kretzschmar G, Ryazanov S, Leonov A, Griesinger C, & Giese A (2015)
Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.
J Neuropathol Exp Neurol. 2015 Aug 5. [Epub ahead of print]
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming C, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, & Rominger A (2015)
Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Mol. Psychiatry, 20(10):1179-87
Hetterich H, Willner M, Habbel C, Herzen J, Hoffmann V, Fill S, Hipp A, Marschner M, Auweter S, Massberg S, Reiser M, Pfeiffer F, Saam T, & Bamberg F (2015)
X-ray Phase-Contrast Computed Tomography of Human Coronary Arteries
Invest Radiol, 50(10):686-94
Rachinger W., Stöcklein V., Terpolilli N., Haug A., Ertl L., Schichor C, Thon N., & Tonn J. (2015)
Increased [68Ga]-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue.
J Nucl Med, 56(3):347-53.
Dorostkar MM, Blazquez-Llorca L, & Herms J (2015)
Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities.
Acta Neuropathol. 130(1):1-19
de Boni L, Riedel L, Schmitt I, Kaut O, Piston D, Akbarian S, & Wüllner U (2015)
DNA methylation levels of α-synuclein intron 1 in the aging brain.
Neurobiol Aging. 2015 Sep 8. pii: S0197-4580(15)00445-5. doi: 10.1016/j.neurobiolaging.2015.08.028. [Epub ahead of print]
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel A, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, & Haass C (2015)
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Nature. 526(7573):443-7
Füllhase C, Schreiber A, Giese A, Schmidt M, Montorsi F, Gratzke C, La Croce G, Castiglione F, Stief C, & Hedlund P (2015)
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats.
Neurourol Urodyn. 2015 Mar 18. doi: 10.1002/nau.22753. [Epub ahead of print]
Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming C, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, & Rominger A (2015)
Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
PLoS ONE. 10(2):e0116678
Ghio S, Kamp F, Cauchi R, Giese A, & Vasallo N (2015)
Interaction of α-synuclein with biomembranes in Parkinson's disease -role of cardiolipin.
Prog Lipid Res. 2015 Dec 15;61:73-82. doi: 10.1016/j.plipres.2015.10.005.
Deeg AA, Reiner AM, Schmidt F, Schueder F, Ryazanov S, Ruf VC, Giller K, Becker S, Leonov A, Griesinger C, Giese A, & Zinth W (2015)
Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-Synuclein aggregates.
Biochim Biophys Acta. 2015 Sep;1850(9):1884-90. doi: 10.1016/j.bbagen.2015.05.021. Epub 2015 May 29.
Kunadt M1, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, & Schneider A (2015)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.
Acta Neuropathol. 2015 May;129(5):695-713. doi: 10.1007/s00401-015-1408-1.
Greiner A, Guibourt V, & Kretzschmar HA (2015)
Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma.
J Cancer. 2015 Jul 15;6(9):832-42. doi: 10.7150/jca.12010. eCollection 2015. PMID:26284134
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming C, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, & Rominger A (2015)
Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
Mol. Psychiatriy, 20(10):1141
Wollenweber FA, Hanecker P, Bayer-Karpinska A, Malik R, Bäzner H, Moreton F, Muir KW, Müller S, Giese A, Opherk C, Dichgans M, Haffner C, & Duering M (2015)
Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro.
Stroke. 2015 Mar;46(3):786-92. doi: 10.1161/STROKEAHA.114.007472. Epub 2015 Jan 20.
Wagner M, Steinbacher J, Michalakis S, Hackner B, Pfaffeneder T, Perera A, Müller M, Giese A, Kretzschmar HA†, & Carell T (2015)
Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues.
Angew Chem Int Ed Engl. 2015 Jul 3. doi: 10.1002/anie.201502722.
Thor T, Künkele A, Pajtler K, Wefers A, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Solomentsew N, Becker L, Garret L, Hölter S, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Eggert A, Schramm A, & Schulte J (2015)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Int J Cancer, 136(10):2293-303.
Filser S, Ovsepyan S, Masana M, Brandt-Elvang A, Volbracht C, Müller MB, Jung CK, & Herms J (2015)
Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions.
Biol Psychiatry. 77(8):729-39
Schludi MH, May S, Grässer FA, Rentzsch K, Kremmer E, Küpper C, Klopstock T, German Consortium for Frontotemporal Lobar Degeneration (Adrian Danek, Janine Diehl-Schmid, Klaus Fassbender, Hans Förstl, Johannes Kornhuber, Markus Otto), Danek A, Diehl-Schmid J, Fassbender K, Förstl H, Kornhuber J, Otto M, Bavarian Brain Banking Alliance (Andres Ceballos-Baumann, Mariane Dieterich, Regina Feuerecker, Armin Giese, Hans Klünemann, Alexander Kurz, Johannes Levin, Stefan Lorenzl, Thomas Meyer, Georg Nübling, Sigrun Roeber), Ceballos-Baumann A, Dieterich M, Feuerecker R, Giese A, Klünemann H, Kurz A, Levin J, Lorenzl S, Meyer T, Nübling G, Roeber S, Arzberger T, & Edbauer D. (2015)
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing.
Acta Neuropathol. 2015 Jun 18. [Epub ahead of print]
Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Högen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E, & Kümpfel T (2015)
Histopathology and clinical course of MOG-antibody-associated encephalomyelitis.
Ann Clin Transl Neurol. 2015;2:295-301.
Levin J, Bak TH, Rominger A, Mille E, Arzberger T, Giese A, Ackl N, Lorenzl S, Bader B, Patzig M, Bötzel K, & Danek A (2015)
The association of aphasia and right-sided motor impairment in corticobasal syndrome.
J Neurol. 2015 Jul 5. [Epub ahead of print]
Thon N, Kunz M, Lemke L, Jansen NL, Kreth S, Lutz J, Egensperger R, Giese A, Herms J, Weller M, Kretzschmar HA, Tonn JC, La Fougère C, & Kreth FW (2015)
Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.
Int J Cancer.136(9):2132-45
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt H, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA †, Griesinger C, Giese A, & Fuhrmann M (2015)
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta Neuropathol. 2015 Oct 6. [Epub ahead of print]
Berger F., & Kretzschmar H (2015)
A 59-year old man with two cerebellar lesions and disturbed cerebellar morphology
Brain Pathol, 25(6):790-1
Torchia J, Picard D, Lafay-Cousin L, Hawkins C, Kim S, Letourneau L, Ra Y, Ho K, Chan T, Sin-Chan P, Dunham C, Yip S, Ng H, Lu J, Albrecht S, Pimentel J, Chan J, Somers G, Zielenska M, Faria C, Roque L, Baskin B, Birks D, Foreman N, Strother D, Klekner A, Garami M, Hauser P, Hortobagyi T, Wilson B, Hukin J, Carret A, van Meter T, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat D, Scheinemann K, Johnston D, Micheaud J, Zelcer S, Hammond R, Ramsay D, Fleming A, Lulla R, Fangusaro J, Sirachainan N, Barakzai M, Montpetit A, Stephens D, Grundy R, Nicolaides T, Tihan T, Philips J, Taylor M, Rutka J, Dirks P, Bader G, Warmuth-Metz M, Rutkowski S, Pietsch T, Judkins A, Jabado N, Bouffet E, & Huang A (2015)
Molecular subgroups of atypical teratoid rhabdoid tumors in children: an integrated genomic and clinicopathological analysis
Lancet Oncol, 16(5):569-82
Ochs S, Dorostkar M, Aramuni G, Schön C, Filser S, Kremer A, van Leuven F, Ovsepian S, & Herms J (2015)
Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin
Mol Psychiatry, in press
Korshunov A., Jakobiec F, Eberhart C, Hovestadt V, Capper D, Jones D., Sturm D, Stagner A, Deepak E, Eagle R, Prioa A, Koch A, Ryzhova M, Ektova A, Lichter P., von Deimling A., Pfister S, & Kool M. (2015)
Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities.
Neuropathology, 35(6):538-44.
(2015)
Localization of SHH medulloblastoma in mice depends on the age at its initiation
Acta Neuropathol, 130(2):307-9.
Koch A (2015)
Histological subtype of medulloblastoma frequently changes upon recurrence
Acta Neuropathol, 129(3):459-61.
nach oben

2014

Levin J, Bader B, Lorenzl S, Hillmer A, Högen T, Kamp F, & Giese A (2014)
Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers.
PLoS One. 2014 Jun 9;9(6):e98906. doi: 10.1371/journal.pone.0098906
Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Herms J, Hugo HH, Schulte M, & Möller P (2014)
Molecular profiling of chordoma
Int J Oncol 2014, 44(4):1041-55
Kleele L, Wiliams P, Stern S, Weigand E, Engerer P, Naumann R, Hartmann J, Karl R, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, & Misgeld T (2014)
An assay to image neuronal microtubule dynamics in mice.
Nat Commun., 5:4827
Topka S, Glassmann A, Weisheit G, & Schilling K (2014)
The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis
The cerebellum, 13(6):698-712.
Leidel F, Eiden M, Geissen M, Hirschberger T, Tavan P, Giese A, Kretzschmar HA, Schätzl H, & Groschup MH (2014)
Piperazine derivatives inhibit PrP/ PrPres propagation in vitro and in vivo
Biochemical and Biophysical Research Communications (2014, in press)
Guibourt V, & Kretzschmar HA (2014)
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
J Neural Transm. 2014 Dec 4. doi: 10.1007/s00702-014-1346-4. Epub ahead of print.
Greiner A, Guibourt V, & Kretzschmar HA (2014)
Long non-coding RNA normalisers in human brain tissue.
J Neural Transm. 2014 Dec 21. doi: 10.1007/s00702-014-1352-6. Epub ahead of print.
Levin J, Schmidt F, Boehm CA, Prix C, Bötzel K, Ryazanov S, Leonov A, Griesinger C, & Giese A (2014)
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.
Acta Neuropathol. 2014 Mar 11. [Epub ahead of print]
Pfeifenbring S., von Baumgarten L., Rosewich H., Thal D., Wirtz R., Hecht M., Terpolilli N., & Brück W. (2014)
Biopsy findings of symptomatic cerebral x-linked adrenoleukodystrophy and histological differentiation to multiple sclerosis.
Neuropathol. Appl. Neurobiol., 40(5):658-61.
Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, & Rominger A (2014)
Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET
Neuroimage 2014, 84:843-53
Burgold S, Filser S, Dorostkar MM, Schmidt B, & Herms J (2014)
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
Acta Neuropathol Commun.,2014, 2(1):30
Levin J, Tiedt S, Arzberger T, Biskup S, Schuberth M, Stenglein-Krapf G, Kreth FW, Högen T, La Fougere C, Linn J, van der Knaap MS, Giese A, Kretzschmar HA, & Danek A (2014)
Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.
Clin Neurol Neurosurg. 2014 Jul;122:113-5
Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F, & Herms J (2014)
Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.
Transl Psychiatry. 2014 Dec 16;4:e489. doi: 10.1038/tp.2014.132.
Neuner J, Filser S, Michalakis S, Biel M, & Herms J (2014)
A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network
Sci Rep. 2014, 4:3931
Dorostkar MM, Burgold S, Filser S, Barghorn S, Schmid B, Anumala UR, Hillen H, Klein C, & Herms J (2014)
Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model
Brain. 137(Pt 12):3319-2
Herms J (2014)
In memoriam: Hans A. Kretzschmar (1953 – 2014)
Brain Pathol., 2014, 24(3):311-2
Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A, & Kreth FW (2014)
Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients.
Acta Neurochir 2014, 156(8):1427-40
Neuner J, Ovsepian S, Dorostkar MM, Filser S, Gupta A, Michalakis S, Biel M, & Herms J (2014)
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
Nat Commun.2014, 5:3915
Respondek G, Stamelou M, Kurz C, Ferguson LW, Rajput A, Chiu WZ, van Swieten JC, Troakes C, Al Sarraj S, Gelpi E, Gaig C, Tolosa E, Oertel WH, Giese A, Roeber S, Arzberger T, Wagenpfeil S, Höglinger GU, & for the Movement Disorder Society-endorsed PSP Study Group (2014)
The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases.
Mov Disord. 2014 Dec;29(14):1758-66. doi: 10.1002/mds.26054. Epub 2014 Nov 5.
Kast J, Hanecker P, Beaufort N, Giese A, Joutel A, Dichgans M, Opherk C, & Haffner C (2014)
Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.
Acta Neuropathol Commun. 2014 Aug 13;2(1):96
Hetterich H, Willner M, Fill S, Herzen J, Bamberg F, Hipp A, Adam-Neumair S, Wirth S, Reiser M, Pfeiffer F, & Saam T (2014)
Phase-Contrast Computed Tomography: Qualitative and Quantitative Evaluation of Atherosclerotic Carotid Artery Plaque
Radiology, 271(3):870-8.
Shih D., Northcott P., Remke M., Korshunov A., Ramaswamy V, Kool M., Luu B, Yao Y, Wang X, Dubuc A., Garzia L, Peacock J, Mack S, Wu X, Rolider A, Morrisy S, Cavalli F, Zitterbart K., Faria C., Kren L, Kumabe T., Tominaga T, Ra Y, Garami M, Hauser P., Chan J, Robinson S, Bognar L, Klekner A, Saad A, Liau L., Albrecht S, Fontebasso A., Cinalli G, Iolascon A, Zollo M, Cooper M, Thompson R, Bailey S, Lindsey J, Di Rocco C, Massimi L., Michiels E, Scherer C, Gupta N, Fan X, Muraszko K, Vikhabar R, Eberhart C., Fouladi M, Lach B, Jung S., Wechsler-Reya R, Fevre-Montagne M., Jouvet A., Jabado N., Pollack I., Weiss W., Cho B, Kim S, Wang K., Leonard J., Rubin J., de Torres C, Lavarino C, Mora J, Cho J., Tabori U., Olson J, Gajjar A, Packer R., Rutkowski S., Pomeroy S., French P, Kloosterhof N, Kros J, von Meir E., Clifford S, Delattre O, Doz F, Reynaud S, Hawkins C., Maliin D, Grabjkowska W., Perke-Polnik M, Bouffet E., Rutka J, Pfister S, & Taylor M. (2014)
Cytogenetic Prognostication within Medulloblastoma Subgroups.
J Clin Oncol, 32(9):886-96.
Otero J, Kalaszczynska I, Michowski W, Wong M, Gygli P, Gokozan H, Griveau A, Odajima J, Czeisler C, Catacutan F, Murnen A, Sicinski P, & Rowitch D (2014)
Cerebellar cortical lamination and foliation require cyclin A2
Dev Biol, 385(2):328-39.
Moreno N, Schmidt C, Ahlfeld J., Dittmar S, Pfister S, Kool M, & Kerl K (2014)
Loss of Smarc proteins impairs cerebellar development
J Neurosci, 34(40):13486 –13491
Wefers A, Warmuth-Metz M, von Bueren A, Monoranu C, Seelos K, Peraud A, Tonn J, Koch A, Pietsch T, Herold-Mende C, Mawrin C, Schouten-van Meeteren A, van Vuurden D, von Hoff K, Rutkowski S, Pfister S, & Kool M (2014)
Subgroup-specific localization of human medulloblastoma based on pre-operative MRI
Acta Neuropathol, 127(6): 931-33.
Korshunov A., Sturm D, Ryzhova M., Gessi M, Jones D., Hovestadt V, Remke M, Northcott P., Perry A., Picard D., Rosenblum M., Antonelli M, Aronica E., Hasselblatt M., Woehrer A, Zheludkova O, Kumirova E., Puget S, Giangaspero F., Taylor M, Collins V., von Deimling A., Lichter P., Huang A., Pietsch T, Pfister S, & Kool M. (2014)
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
Acta Neuropathol, 128(2):279-289.
Stark S., Neumann P., Gröbner S., Kawauchi D., Jones D., Northcott P., Lichter P., Pfister S., & Kool M. (2014)
Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts
Acta Neuropathol, 128(1):123-36.
Kool M., Jones D., Jäger N., Northcott P., Pugh T., Hovestadt V., Piro R., Esparza L., Markant S., Remke M., Milde T., Bourdeaut F., Rizhova M., Sturm D., Pfaff E., Stark S., Hutter S., Seker-Cin H., Johann P., Bender S., Schmidt S., Rausch T., Shih D., Reimand J., Sieber L., Wittmann A., Linke L., Weber U., Zapatka M., van Sluis P., Volckmann R., Koster J., Versteeg R., Schmdit S., Wolf S., Lawerenz C., Bartholomae C., von Kalle C., Unterberg A., Herold-Mende C., Hofer S., Kulozik A., von Deimling A., Scheurlen W., Felsberg J., Reifenberger G., Hasselblatt M., Crawford J., Grant G., Jabado N., Perry A., Cowdrey C., Croul C., Zadeh G., Korbel J., Doz F, Delattre O, Bader G., McCabe M., Collins P., Kieran M., Cho Y., Pomeroy S., Witt O., Brors B., Taylor M., Korshunov A., Eils R., Wechsler-Reya R., Lichter P., & Pfister S (2014)
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened-Inhibition
Cancer Cell, 25:393–405
Hasselblatt M, Nagel I, Oyen F, Bartelheim K, Russel R, Junckersdorff R, Rosenblum M, Alassiri A, Rossi S, Schmid I, Gottardo N, Toledano H, Viscardi E, Balbin M, Witkowski L, Lu Q, Betts M, Siebert R, Frühwald M, & Schneppenheim R (2014)
SMARCA4 mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis.
Acta Neuropathol, 128:453-456.
Bartels M, Kuteykin-Teplyakov K., & Ahlfeld J (2014)
Wnt/β-catenin-signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma
Acta Neuropathol, 127(4):605–607
Kerl K, Moreno N, Holsten T, Ahlfeld J., Mertins J, Horfilder M, Kool M, Bartelheim K, Schleicher S, Handgretinger R, Meisterernst M, & Frühwald M (2014)
Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1
Int J Cancer, 135(4):989-95
Hütz K, Mejias-Luque R, Farsakova K, Ogris M, Krebs S, Blum H, Anton M, Vieth M, Schneider M, Wagner E, Jung A, & Gerhard M (2014)
The stem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells
Carcinogenesis, 35(4):942-50.
nach oben

2013

Saverioni D, Notari S, Capellari S, Poggiolini I, Giese A, Kretzschmar HA, & Parchi P (2013)
Analyses of protease-resistance and aggregation state of abnormal prion protein across the spectrum of human prions.
J Biol Chem. 2013 Jul 29. [Epub ahead of print], doi: 10.1074/jbc.M113.477547
Ovsepian SV, O'Leary VB, Zaborsky L, Herms J, & Oliver Dolly J (2013)
Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forbrain cholinergic neurons
Brain Struct Funct. (2013, in press)
Shi S, Mitteregger-Kretzschmar G, Giese A, & Kretzschmar HA (2013)
Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.
Acta Neuropathologica Communications 2013, 1:44, doi:10.1186/2051-5960-1-44
Camilleri A, Zarb C, Caruana M, Ostermeier U, Ghio S, Högen T, Schmidt F, Giese A, & Vassallo M (2013)
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.
BBA - Biomembranes, doi: 10.1016/j.bbamem.2013.06.026
Högen T, Demel C, Giese A, Angele B, Pfister HW, Koedel U, & Klein M (2013)
Adjunctive N-acetyl-L-cysteine in murine pneumococcal meningitis.
Antimicrob. Agents Chemother. published ahead of print 22 July 2013 doi:10.1128/AAC.00148-13
Füllhase C, Hennenberg M, Giese A, Schmidt M, Strittmatter F, Soler R, Gratzke C, Andersson KE, & Stief C (2013)
Presence of phosphodiesterase type 5 (PDE5) in the spinal cord and its involvement in bladder outflow obstruction related bladder overactivity.
The Journal of Urology, published ahead of print 29 March 2013, doi:10.1016/j.juro.2013.03.112
Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar HA, Griesinger C, & Giese A (2013)
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Acta Neuropathol 125(6):795-813. DOI: 10.1007/s00401-013-1114-9.
Honarnejad K, Daschner A, Giese A, Zall A, Schmidt B, Szybinska A, Kuznicki J, & Herms J (2013)
Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease.
PLoS One. 2013;8(11):e80645. doi: 10.1371/journal.pone.0080645
Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, & Haass C (2013)
Longitudinal Assessment of Cerebral β-Amyloid Deposition in Mice Overexpressing Swedish Mutant β-Amyloid Precursor Protein Using 18F-Florbetaben PET
J Nucl Med. 2013, 54(7):1127-34, 2013
Honarnejad K, Kirsch AK, Daschner A, Szybinska A, Kuznicki J, & Herms J (2013)
FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer's disease
J Biomol Screen. 2013, 18(10):1309-20
Saam T, Herzen J, Hetterich H, Fill S, Willner M, Stockmar M, Zanette I, Weitkamp T, Auweter S, Adam-Neumair S, Nikolaou K, Reiser M, Pfeiffer F, & Bamberg F (2013)
Translation of Atherosclerotic Plaque Phase-contrast Imaging from Synchrotron Radiation to a Conventional Lab-based X-ray Source
PLoS One, 8(9):e73513
Brouwer MC, Meijers JC, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D, & Koedel U (2013)
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.
Acta Neuropathol. 2013 Nov 19. [Epub ahead of print], doi:10.1007/s00401-013-1216-4
Ovsepian SV, & Herms J (2013)
Cholinergic neurons-keeping check on amyloid β in the cerebral cortex
Front Cell Neurosc. 2013, 7:252, 2013
Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar HA, & Herms J (2013)
Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease
J Cell Mol med. 2013. 17(2):293-302
Hetterich H, Fill S, Herzen J, Willner M, Zanette I, Weitkamp T, Sadeghi M, Brandl R, Adam-Neumair S, Reiser M, Pfeiffer F, Bamberg F, & Saam T (2013)
Grating-based X-ray phase-contrast tomography of atherosclerotic plaque at high photon energies
Z Med Phys, 23(3):194-203.
Anumala UR, Gu J, Lo Monte F, Kramer T, Heyny-von-Haußen R., Hölzer J., Goetschy-Meyer V., Schön C, Mall G, Hilger I, Czech C, Herms J, & Schmidt B (2013)
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer’s disease brains
Bioorganic & Medicinal Chemistry. 2013, 21(17):5139-44
Ovsepian SV, & Herms J (2013)
Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system
Neurobiology of Aging 2013, 34(11):2517-24
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, & Herms J (2013)
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
PLoS One. 2013;8(11):e80645. doi: 10.1371/journal.pone.0080645
Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, & Edbauer D (2013)
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Science Published Online DOI: 10.1126/science.1232927
Mori K, Lammich S, Mackenzie IRA, Forné I, Zilow S, Kretzschmar HA, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, & Haass C (2013)
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
Acta Neuropathologica Published Online DOI: 10.1007/s00401-013-1088-7
Sanin V, Heeß C, & Kretzschmar H.A (2013)
Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischemia.
Neuropathol Appl Neurobiol, 39:510–518.
Zhukova N, Ramaswamy V, Remke M., Shih D., Martin D., Castelo-Branco P., Baskin B., Ray P., Bouffet E., von Bueren A., Pfaff E., Korshunov A., Jones D., Northcott P., Kool M., Pugh T., Pomeroy S., Cho J., Pietsch T., Gessi M., Rutkowski S., Bogntr L., Klekner A., Cho B., Kiom S., Wang K., Eberhart C., Fevre-Montagne M., Fouladi M., French P., Kros M., Grabjkowska W., Gupta N., Weiss W., Hauser P., Jabado N., Jouvet A., Jung S., Kumabe T., Lach B., Leonard J., Rubin J., Liau L., Massimi L., Pollack I., Ra Y., von Meir E., Zitterbart K., Hill R., Lindsey J., Schwalbe E., Bailey S., Ellison D., Hawkins C., Malkin D., Clifford S., Pfister S, Taylor M., & Tabori U. (2013)
Subgroup Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
J Clin Oncol, 31(23):2927-35
Schaffer M, Hofstetter A, Ertl-Wagner B, Batash R, & Schaffer P (2013)
Treatment of Astrocytoma Grade III with Photofrin II as a radiosensitiser, a case report
Strahlenther Onkol, in press
Ramaswamy V, Remke M., Bouffet E., Faria C., Perrault S., Cho J., Shih D., Luu B., Dubuc A., Norhtcott P., Gururangan S., McLendon R, Bigner D., Fouladi M., Ligon K., Pomeroy S., Dunn S., Triscott J., Jabado N., Fontebasso A., Jones D., Kool M., Karajannis M., Gardner S., Zagzag D., Nunes S., Pimentel S., Mora J., Lipp E., Walter A., Ryzhova M., Zheludkova O., Kumirova E., Alshami J., Rutka J., Hawkins C., Tabori U., Codispoti K., Packer R., Pfister S, Korshunov A., & Taylor M. (2013)
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
Lancet Oncol., 14(12):1200-7.
Pöschl J, Grammel D., Dorostkar M., Kretzschmar H.A, & Schüller U. (2013)
Constitutive activation of ß-Catenin in neural progenitors results in disrupted proliferation and migration of neurons within in the central nervous system
Dev Biol 374:319-332 (cover story).
Remke M., Ramaswamy V, Peacock J, Shih D., Koelsche C, Northcott P., Zhukova N, Martin D., Bouffet E., Kool M., Pomeroy S., Cho J., Rutkowski S., Wang K., Eberhart C., Fevre-Montagne M., Grabjkowska W., Weiss W., Hauser P., Jabado N., Jouvet A., Jung S., Kumabe T., Leonard J., Rubin J., Liau L., Massimi L., Pollack I., von Meir E., Zitterbart K., Hawkins C., Hill N, Cavalli F, Mack S, Barczyck M, Morrisy S, Wu X, Agnihotri S, Luu B, Garzia L, Dubuc A., Vanner R, Kros J, French P, Vikhabar R, Chan J, Klekner A, Lach B, Saad A, Albrecht S, Zollo M, Cooper M, Thompson R, Delattre O, Bourdeault F, Doz F, Garami M, Carlotti C, Van Meter T, Fults D, Mora J, McLendon R, Bigner D., Faria C., Croul S, Dirks P, Kim S, Rutka J, Malkin D., Tabori U., Pfister S, Korshunov A., von Deimling A, & Taylor M. (2013)
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
Acta Neuropathologica, 126(6):917-29.
Ahlfeld J., Favaro R., Pagella P, Kretzschmar H.A, & Nicolis S. (2013)
Sox2 requirement in Sonic-hedgehog-associated medulloblastoma
Cancer Res, 73(12); 3796–807.
nach oben

2012

Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomäki H, Teichert M, Huang H, Edquist PH, Augustin HG, Olofsson T, Larsson E, Söderberg O, Molema G, Pontén F, Georgii-Hemming P, Alafuzoff I, & Dimberg A (2012)
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.
J Pathol. 2012 Nov;228(3):378-90. doi: 10.1002/path.4072. Epub 2012 Aug 31.
Caruana M, Neuner J, Högen T, Schmidt F, Kamp F, Scerri C, Giese A, & Vassallo N (2012)
Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro.
Biochim Biophys Acta. 2012 May 23. [Epub ahead of print]
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, & Herms J (2012)
Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice
PLoS One. 2012, 7(12):e53547
Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar HA, Bötzel K, Kamp F, & Giese A (2012)
Two different binding modes of α-Synuclein to lipid vesicles depending on its aggregation state.
Biophys J, 102, 1646-1655.
Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, & Koch A (2012)
Combination of Hedgehog Signaling Blockage and Chemotherapy Leads to Tumor Reduction in Pancreatic Adenocarcinomas
Pancreas, 41(2):222-9
von Baumgarten L., Pfeifenbring S., Terpolilli N., Jahn K., Opherk C., & Freilinger T. (2012)
A young man with symptomatic epilepsy and right hemianopia: Family affair
Neurology, 79(19):2008-9.
Globisch D, Wagner M, Münzel M, Müller M, Pfaffeneder T, Hackner B, Feiden W, Carell T, & Kretzschmar H.A (2012)
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.
Int J Cancer. 2012 Oct 1;131(7):1577-90. doi: 10.1002/ijc.27429. Epub 2012 Mar 2.
Willhauck MJ, Pöpperl G, Rachinger W, Giese A, Auernhammer CJ, & Spitzweg C (2012)
An unusual case of ectopic ACTH syndrome.
Exp Clin Endocrinol Diabetes. 2012 Feb;120(2):63-7.
Jansen NL, Graute V, Armbruster L, Suchorska B, Lutz J, Cumming P, Bartenstein P, Tonn JC, Kreth FW, & la Fougère C (2012)
MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET?
Eur J Nucl Med Mol Imaging, 39(6), 1021-9. Epub 2012 Apr 11.
Nübling G, Levin J, Bader B, Israel L, Bötzel K, Lorenzl S, & Giese A (2012)
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation.
Exp Neurol. 2012 Aug 6. [Epub ahead of print]
Niyazi M, Schnell O, Suchorska B, Schwarz SB, Ganswindt U, Bartenstein P, Kreth FW, Tonn JC, Belka C, & la Fougère C (2012)
FET-PET assessed recurrence pattern after radio-chemotherapy in newly diagnosed patients with glioblastoma is influenced by MGMT methylation status.
Radiother Oncol. 2012 Jul;104(1):78-82. Epub 2012 Jun 5.
Thon N, Jansen N, Janssen H, Mielke J, Ruiter M, la Fougère C, Peraud A, Egensperger R, & Kretzschmar HA (2012)
Intramedullary pilomyxoid astrocytoma with intracerebral metastasis exhibiting oligoden-droglioma-like features.
Rare Tumors. 2012 Apr 12;4(2):e30. Epub 2012 May 31.
Schnell O, Romagna A, Jaehnert I, Albrecht V, Juerchott K, Kretzschmar HA, Tonn JC, & Schichor C (2012)
Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.
PLoS ONE, 7(1), e30429.
Brucker D, & Herms J (2012)
A Window into Metastasis
Sci Translational Medicine, 2012, 4(158):158fs39
Göbel W, Brucker D, Kienast Y, Johansson A, Kniebühler G, Rühm A, Eigenbrod S, Fischer S, Goetz M, Kreth FW, Erhardt A, Stepp H, Irion KM, & Herms J (2012)
Optical needle endoscope for safe and precice stereotactically guided biopsy sampling in neurosurgery
Opt Express, 2012, 20(24):26117-26, 2012
Schmidt F, Levin J, Kamp F, Kretzschmar HA, Giese A, & Bötzel K (2012)
Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes.
PLoS ONE 2012, 7(8): e42545.
Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, Kretzschmar HA, & Herms J (2012)
Amyloid plaque formation precedes dendritic spine loss
Acta Neuropathol. 2012, 124(6):797-807
Bader B, Levin J, Hildebrandt J, Kretzschmar HA, & Giese A (2012)
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level.
Molecular Neurodegeneration 2012, 7:35.
Jung CK, & Herms J (2012)
Role of APP for dendritic spine formation and stability
J Neurochem. 2012, 119(5):1064-73
Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar HA, & Herms J (2012)
Presenilins: Role in calcium homeostasis
Int J Biochem Cell Biol. 2012, 44(11):1983-1986
Dorostkar MM, & Herms J (2012)
Arc illuminates Alzheimers’s pathophysiology
Nat. Neurosci.2012, 5(10):1323-5
Breithaupt M, Romero C, Kallenberg K, Begue C, Sanchez-Juan P, Kretzschmar HA, Schelzke G, Meichtry E, Taratuto A, & Zerr I (2012)
Magnetic Resonance Imaging in E200K and V210I Mutations of the Prion Protein Gene.
Alzheimer Dis Assoc Disord. 2012 Mar 8. [Epub ahead of print]
Fiorino F, Eiden M, Giese A, Severino B, Esposito A, Groschup MH, Perissutti E, Magli E, Incisivo GM, Ciano A, Frecentese F, Kretzschmar HA, Wagner J, Santagada V, & Caliendo G (2012)
Synthesis of benzamide derivatives and their evaluation as antiprion agents.
Bioorg Med Chem. 2012 Jun 20. [Epub ahead of print]
Jung CK, & Herms J (2012)
Structural Dynamics of Dendritic Spines are Influenced by an Environmental Enrichment – an in vivo Imaging Study
Cereb Cortex 24(2):377-84
Boländer A, Kieser D, Voss C, Bauer S, Burgold S, Bittner T, Hölzer J, Heyny-von-Haußen R., Mall G, Goetschy V., Czech C, Knust H, Berger R, Herms J, Hilger I, & Schmidt B (2012)
Bis(arylvinyl)pyrazines, -pyrimidines, and –pyridazines As Imaging Agents for Tau Fibrils and β-Amyloid Plaques in Alzheimer’s Disease Models
J Med Chem. 2012, 31.55(21):9170-80
Parchi P, de Boni L, Saverioni D, Cohen ML, Ferrer I, Gambetti P, Gelpi E, Giaccone G, Hauw JJ, Höftberger R, Ironside JW, Jansen C, Kovacs GG, Rozemuller A, Seilhean D, Tagliavini F, Giese A, & Kretzschmar HA (2012)
Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA.
Acta Neuropathol. 2012 Jun 30. [Epub ahead of print]
Dimopoulou C, Ormanns S, Müller-Lisse U, Emmerich B, & Reincke M (2012)
Extramedullary Multiple Myeloma Presenting as a Pituitary Mass Lesion.
Exp Clin Endocrinol Diabetes. 2012 Jul 31. [Epub ahead of print]
Frick A, Schmidt F, Priller M, Pagella P, von Bueren A, Peraud A, Tonn J, Herms J, Rutkowski S, & Kretzschmar H.A (2012)
Proper cerebellar development requires expression of beta1-integrin in Bergmann glia, but not in granule neurons
Glia, 60:820–832 (cover story)
Jäger N., Kool M., Zichner T., Hutter B., Sultan M., Cho Y., Pugh T., Hovestadt V., Stütz A., Rausch T., Warnatz H., Ryzhova M., Bender S., Sturm D., Pleier S., Cin H., Pfaff E., Sieber L., Wittmann A., Remke M., Witt H., Hutter S., Tzaridis T., Weischenfeld J., Raeder B., Avci M., Amstislavskiy V., Zapatka M., Weber U., Wang Q., Lasitschka B., Barttholomae C., Schmidt M., von Kalle C., Ast V., Lawerenz C., Eils J., Kabbe R., Benes V., von Sluis P., Koster J., Volckmann R., Shih D., Betts M., Russel R., Coco S., Tonini G., Hans V., Graf N., Kim Y., Monoranu C., Roggendorf W., Unterberg A., Herold-Mende C., Milde T., Kulozik A., von Deimling A., Witt O., Wiemann S., Lehrach H., Brors B., Scheurlen W., Felsberg J., Reifenberger G., Northcott P., Taylor M., Meyerson M., Pomeroy S., Yaspo M., Korbel J., Korshunov A., Eils R., Pfister S, & Lichter P. (2012)
Dissecting the genomic complexity underlying medulloblastoma.
Nature, 488:100-105
Korshunov A., Ryzhova M., Jones D., Northcott P., van Sluis P., Volckmann R., Koster J., Versteeg R., Cowdrey C., Perry A., Picard D., Rosenblum M., Giangaspero F., Aronica E., Hasselblatt M., Collins V., von Deimling A., Lichter P., Huang A., Pfister S, & Kool M. (2012)
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
Acta Neuropathol, 124(6):875-81.
Adam A, Schnell O, Kretzschmar H.A, & Tonn J (2012)
ALDH1A1 is a marker of astrocytic differentiation that correlates with better survival in glioblastoma patients
Brain Pathol, 22(6):788-97
Hokkanen S, Feldmann H, Ding H, Bojarski L, Kretzschmar H.A, Wolf E, & Herms J (2012)
Lack of Pur-alpha alters postnatal brain development and causes megalencephaly
Hum Mol Genet, 21(3):473-84.
Warmuth-Metz M, von Bueren A, Kool M, Pietsch T, Kretzschmar H.A, Rowitch D, Rutkowski S, & Pfister S (2012)
Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem
Acta Neuropathol, 123(4):601-14
nach oben

2011

Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, & Giese A (2011)
Generation of Ferric Iron Links Oxidative Stress to alpha-Synuclein Oligomer Formation.
Journal of Parkinson’s Disease (2011) 1: 205-216
Bader B, Nübling G, Mehle A, Nobile A, Kretzschmar HA, & Giese A (2011)
Single particle analysis of tau oligomer formation induced by metal ions and organic solvents.
Biochem Biophys Res Commun. 2011 Jul 22;411(1):190-6.
Geissen M, Leidel F, Eiden M, Hirschberger T, Fast C, Bertsch U, Tavan P, Giese A, Kretzschmar HA, Schatzl HM, & Groschup MH (2011)
From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.
ChemMedChem. 2011 Oct 4;6(10): 1928-37
Kunz M, Thon N, Hartmann C, Egensperger R, Herms J, Geisler J, la Fougere C, Lutz J, Linn J, Kreth S, von Deimling A, Tonn JC, Kretzschmar HA, Pöpperl G, & Kreth FW (2011)
Hot spots in dynamic18FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas.
Neuro Oncol. 2011 Feb 3.
Thon N, Kreth S, Lutz J, Tonn JC, Kretzschmar H, Peraud A, & Kreth FW (2011)
IDH1 mutations in grade II atrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival.
Cancer. 2011 Jun 29.
Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, & Herms J (2011)
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis
EMBO J. 2016, 35(20):2213-2222
Demel C, Högen T, Giese A, Angele B, Pfister HW, Koedel U, & Klein M (2011)
Reduced spiral ganglion neural loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
J Neuroinflammation. 2011 Jan 24;8(1):7.
Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, & Herms J (2011)
Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo
J Neurochem. 2011, 119(5):1064-73
Gauci AJ, Caruana M, Giese A, Scerri C, & Vassalo N (2011)
Identification of Polyphenolic Compounds and Black Tea Extract as Potent Inhibitors of Lipid Membrane Destabilization by Aβ42 Aggregates.
J Alzheimers Dis. 2011 Sep 2. (Epub ahead of print)
Niyazi M, Zehentmayr F, Niemöller OM, Kretzschmar HA, Osthoff KS, Tonn JC, Atkinson M, Mörtl S, & Belka C (2011)
MiRNA expression patterns predict survival in glioblastoma.
Radiat Oncol, Nov 10, 6, 153.
Schelzke G, Romero C, Varges D, Breithaupt M, Taratutu AL, Kretzschmar HA, & Zerr I (2011)
Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings.
Neurobiol Aging. 2011 Jan 11.
Scheibe S, Dorostkar MM, Seebacher D, Uhl R, Lison F, & Herms J (2011)
4D in vivo 2-photon laser scanning fluorescence microscopy with sample motion in 6 degrees of freedom
J. Neurosci Methods. 2011, 200(1):47-53
Leidel F, Eiden M, Geissen M, Kretzschmar HA, Giese A, Hirschberger T, Tavan P, Schätzl HM, & Groschup MH (2011)
Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.
Antimicrob Agents Chemother. 2011 Oct; 55(19): 4774-81.
Felsberg J, Thon N, Hentschel B, Sabel MC, Westphal M, Schackert G, Kreth FW, Pietsch T, Löffler M, Weller M, Reifenberger G, Tonn JC, & German Glioma Network (2011)
Promotor methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.
Int J Cancer 129(3):659-70.
Tierling S, Roeber S, Walter J, Giese, A, & Kretzschmar HA (2011)
Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease.
Neuromolecular Med. 2011Nov 1. (Epub ahead of print)
Duering M, Karpinska A, Rosner S, Hopfner F, Zechmeister M, Peters N, Kremmer E, Haffner C, Giese A, Dichgans M, & Opherk C (2011)
Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis.
Hum Mol Genet. 2011 Aug 15;20(16):3256-65.
Capell A, Liebscher S, Fellerer K, Brouwers S, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, & Haass C (2011)
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase
J. Neurosci. 2011, 31(5):1885-1894
Parchi P, Strammiello R, Giese A, & Kretzschmar HA (2011)
Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future.
Acta Neuropathol. 2011 Jan;121(1):91-112.
von Baumgarten LD, Brucker D, Tirniceru AL, Kienast Y, Grau S, Burgold S, Herms J, & Winkler F (2011)
Bevacizumab has differential and dose-dependent effects on glioma blood vessels and tumor cells
Clin Cancer Res. 2011, 17(19):6192-205
Caruana M, Högen T, Levin J, Hillmer A, Giese A, & Vassallo N (2011)
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds.
FEBS Lett. 2011 Apr 20;585(8):1113-20.
Kreth S, Thon N, Lutz, Ledderose C, Egenperger R, Tonn JC, Hinske LC, & Kreth FW (2011)
O-methylguamine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.
PLoS One. 2011 Feb 18;6(2):e17156.
Giese A, Schelzke G, Zerr I, & Kretzschmar HA (2011)
Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity.
J Neuropathol Exp Neurol. 2011 Mar;70(3):192-200.
Hüls S, Högen T, Vassallo N, Danzer KM, Hengerer B, Giese A, & Herms J (2011)
AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers
J. Neurochem. 2011 1471-4159
Roeber S, Thon N , Giese A, Krieger A, Egensperger R, Tonn JC, Kreth FW, & Kretzschmar H (2011)
α-Internexin in the Diagnosis of Oligodendroglial Tumors and Association With 1p/19q Status.
J Neuropathol Exp Neurol. 2011 Nov;70(11): 970-8.
Priller M, Abrão L, von Bueren A, Cho Y, Rutkowski S, & Kretzschmar H.A (2011)
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
Clin Cancer Res, 17:6791-6801 (cover story)
Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, & Kretzschmar H.A (2011)
Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors
Mol Cell Biol, 31:3326-3338 ('spotlight' article)
Lorenz A, Hartmann W, von Bueren A, Kool M, Li S, Peraud A, Tonn J, Herms J, Xiang M, Rutkowski S, & Kretzschmar H.A (2011)
Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Oncogene, 30(47):4721-30.
nach oben

2010

Heine V, Priller M, Ling J, & Rowitch D (2010)
Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-assiciated medullablastoma
Cancer Res, 70(13):5220-5.
Johansson A, Palte G, Schnell O, Tonn JV, Herms J, & Stepp H (2010)
5-Aminolevulinc Acid-induced Protoporphyrin IX levels in tissue of human malignant brain tumors
Photochem. Photobiol. 2010, 10.1111/j.1751-1097
Parchi P, Cescatti M, Notari S, Schulz-Schaeffer W, Capellari S, Giese A, Zou WQ, Kretzschmar HA, Ghetti B, & Brown P (2010)
Agent strain variation in human prion disease: Insights from a molecular and pathological revision of the NIH series of experimentally transmitted disease.
Brain 2010 Oct;133(10):3030-42.
Sutter R., Shakhova O., Bhagat H., Behesti H., Sutter C., Penkar S., Santuccione A., Bernays R., Heppner F., Grotzer M., Moch H., Schraml P., & Marino S. (2010)
Cerebellar stem cells act as medullablastoma initiating cells in a mouse model and a neural stem cell signature characterises a subset of human medullablastoma.
Oncogene 29(12):1845-56
Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, & Dodel R (2010)
The role of macrophage migration inhibitory factor in Alzheimer's disease.
Mol Med 16(3-4):116-21 (2010).
Peters N, Fesl G, Theil D, Birnbaum T, Brückmann H, & Noachtar S (2010)
Subacute herpes encephalitis presenting as relapsing encephalitis.
J Neurol 257(5):843-5
Grabellus F, Konik MJ, Worm K, Sheu SY, van de Nes JA, Bauer S, Paulus W, Egensperger R, & Schmid KW (2010)
MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions.
Tumour Biol 31(3):157-63 (2010).
Bittner T., Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger-Kretzschmar G, Kretzschmar HA, LaFerla FM, & Herms J (2010)
Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer’s Disease Mice.
PLoS ONE, Nov 2010, 5, 11 / e15477
Kreth S, Heyn J, Grau S, Kretzschmar H, Egensperger R, & Kreth FW (2010)
Identification of valid endogenous control genes for determining gene expression in human glioma.
Neuro-Oncol 12(6):570-9 (2010).
Hillmer, A., Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar HA, McLean PJ, & Giese, A. (2010)
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.
Biochem Biophys Res Commun. (2009), doi:10.1016/j.bbrc.2009.11.080
Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar HA, McLean PJ, & Giese A (2010)
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.
Biochem Biophys Res Commun, 391,461-6.
Albayrak O, Tirniceriu AL, Riemenschneider M, Kurz A, Scherag A, & Egensperger R (2010)
The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.
J Gerontol A Biol Sci Med Sci 65(3):219-24 (2010).
Fuhrmann M, Bittner T., Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, & Herms J (2010)
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Nat Neurosci. 2010 Apr;13(4):411-3.
Pfefferkorn T., Cyran C, Hüfner K, Fesl G, Seelos K, Dichgans M, Pfister H W, Nikolaou K, Kretzschmar HA, & Saam T (2010)
Giant Cell Arteritis of the Basal cerebral Arteries: Correlation of MRI, DSA and Histopathology.
Neurology 74(20):1651-3.
Linn J, Halpin A, Demaerel P, Ruhland J, Giese A, Dichgans M, van Buchem MA, Brükmann H, & Greenberg SM (2010)
The Prevalence of Superficial Siderosis in Patients with Cerebral Amyloid Angiopathy.
Neurology (2010) 74: 1346-1350.
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson TJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, & Lichtenthaler SF (2010)
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
J Neurosci. 2010 Jun 30;30(26):8974-83.
Yoon MS, Bechmann L, Obermann M, Yepnjouo O, Egensperger R, Gerken G, Katsarava Z, Thomale J, & Holtmann G (2010)
Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia.
Neurosci Bull 26(4):282-8 (2010).
De la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Salih D, Rowitch D, Brunet A, & Bonni A (2010)
A FOXO-Pak1 transcriptional pathway controls neuronal polarity.
Genes and Development 24:799-813
El Hindy N, Adamzik M, Lambertz N, Bachmann HS, Worm K, Egensperger R, Frey UH, Asgari S, Sure U, Siffert W, & Sandalcioglu IE (2010)
Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme.
J Cancer Res Clin Oncol 136(9):1423-9 (2010).
Burgold S, Bittner T., Dorostkar MM, Kieser D, Fuhrmann M, Mitteregger-Kretzschmar G, Kretzschmar HA, Schmidt B, & Herms J (2010)
In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks.
Acta Neuropathol. 2010, 121(3):327-35
Kienast Y, von Baumgarten L, Fuhrmann M, Klinkert WE, Goldbrunner R, Herms J, & Winkler F (2010)
Real-time imaging reveals the single steps of brain metastasis formation.
Nat Med. 2010 Jan;16(1):116-22.
Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, & Haass C (2010)
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
EMBO J 2010 Oct 20;29(20):3571-89.
Thon N, Lutz J, Kreth S, Popperl G, Belka C, Kretzschmar HA, Tonn JC, & Kreth FW (2010)
Predominant influence of MGMT methylation in non-resectable glioblastoma afeter radiotherapy plus temozolomide.
J Neurol Neurosurg Psychiatry. 2010 Sep 22.
Levin J, Bulst S, Thirion C, Schmidt F, Bötzel K, Krause S, Pertl C, Kretzschmar HA, Walter MC, Giese A, & Lochmüller H (2010)
Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy.
J Neuropath Exp Neurol (2010) 69: 415-424.
Levin J, Bötzel K, Giese A, Vogeser M, & Lorenzl S (2010)
Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis.
Dement Geriatr Cogn Disord (2010) 29: 553-559.
Rémi J, Pfefferkorn T, König F, Lassmann H, Brück W, Holtmannspötter M, Straube A, & Kretzschmar H (2010)
A 76-year old woman with paraplegia
Brain Pathol, 20:507-10
Grau S, Weiss C, & Tonn J (2010)
Primary meningeal T-cell lymphoma at the Clivus mimicking a Meningioma
World Neurosurg 74:513-516
Saam T, Habs M, Cyran CC, Grimm J, Pfefferkorn T, Kretzschmar HA, Reiser MF, & Nikolaou K (2010)
New aspects of MRI for diagnostics of large vessel vasculitis and primary angiitis of the central nervous system
Radiologe 50:861-871
nach oben

2009

Sostak P, Padovan CS, Roeber S, Segerer S, Schankin C, Siegert S, Saam T, Theil D, Kolb HJ, Kretzschmar HA, & Straube A (2009)
Cerebral angiitis in four patients with chronic GVHD.
Bone Marrow Transplant. 2009 Nov. 16.
Thon N, Ruiter M, Mehrkens JH, Kreth S, Tonn JC, Kretzschmar HA, & Kreth FW (2009)
Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1p/19q and TP53 mutations in Wolrd Health Organization grade II gliomas.
J Neuropathol Exp Neurol. 2009 Nov; 68(11):1219
Yoon MS, Katsarava Z, Obermann M, Schäfers M, Liedert B, Dzagnidze A, Kribben A, Egensperger R, Limmroth V, Diener HC, & Thomale J (2009)
Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of cisplatin-induced neuropathy.
BMC Neurosci 10:77 (2009).
Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpoi E, Gentleman S, Giaccone G, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Parkkinen L, Patsouris E, Roggendorf W, Rozemuller A, Stadelmann-Nessler C, Streichenberger N, Thal DR, & Kretzschmar HA. (2009)
Staging/typing of Lewy body-related alpha-synuclein.
Acta Neuopathol 117:635-652
Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Al-Sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E, Gentleman S, Giaccone G, Graeber M, Hortobagyi T, Höftberger R, Ince P, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranou C, Nilsson T, Parchi P, Patsouris E, Pikkarainen M, Revesz T, Rozemuller A, Seilhean D, Schulz-Schaefer W, Streichenberger N, Wharton SB, & Kretzschmar HA. (2009)
Assessment of beta-amyloid deposits in human brains. A Study of the BrainNet Europe Consortium.
Acta Neuropath 117:309-320
Bensimon G, Ludolph A, Agid Y, Vidailhet M, Leigh PN, & NNIPPS Study Group (2009)
Riluzole treatment, survival, and diagnostic criteria in Parkionson plus disorders: the NNIPPS study.
Brain 132:156-171
Bittner T., Fuhrmann M, Burgold S, Volbracht C, Steiner H, Mitteregger G, Kretzschmar H, Haass, & Herms J (2009)
Gamma-Secretase inhibition reduces spine density in vivo via an APP-dependent pathway.
J Neurosci. 2009 Aug 19;29(33):10405-9.
Dewachter I, Filipkowski R.K, Priller C, Neyton J, Ris L, Terwel D, Gysemans M, Borghgraef P, Croes S, Godaux E, Kaczmarek L, Herms J, & Van Leuven F. (2009)
Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.
Neurobiol. of Aging 30:241-56.
Endres K, Mitteregger G, Kojro E, Kretzschmar H, & Fahrenholz (2009)
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo.
Neurobiol Dis. 2009 Jul 24.
weiter Abstract (PDF)
Gierga K, Schelhaas HJ, Brunt ER, Seidel K, Scherzed W, Egensperger R, de Vos RA, den Dunnen W, Ippel PF, Petrasch-Parwez E, Deller T, Schöls L, & Rüb U. (2009)
Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites.
Neuropathol Appl Neurobiol. 2009 Oct;35(5):515-27. Epub 2009 Jan 30.
Jahn K, Arbusow V, Zingler VC, Strupp M, Kretzschmar HA, & Brandt T (2009)
Bilateral vestibular failure as an early sign in Creutzfeldt- Jakob disease.
Ann N Y Acad Sci 1164:390-393
Jesse S, Steinacker P, Cepek L, Arnim CV, Tumani H, Lehnert S, Kretzschmar HA, Baier M, & Otto M (2009)
Glial fibrillar acidic protein and S-100B: Different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's Disease and Creutzfeldt-Jakob disease.
J Alzheimers Dis [Epub ahead of print]
Kienast Y, v. Baumgarten L, Fuhrmann M, Klinkert W. E, Goldbrunner R, Herms J., Winkler F, & Journal Artikel (2009)
The evolution of brain metastasis formation: real-time imaging reveals its mandatory and inefficient steps.
Nature Med. (in press) * shared senior authorship
Kretzschmar HA (2009)
Brain banking: opportunities, challenges and meaning for the future.
Nature Reviews Neuroscience. 10:70-78
Kretzschmar HA, & Illig T (2009)
Are further genetic factorsassociated with the increased risk of developing variant Creutzfeldt- Jakob disease?
Lancet Neurology. 8:25-26
Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, Kretzschmar H, & Lorenzl S (2009)
Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.
Exp Neurol. 2009 Jan;215(1):201-8.
Ludolph AC, Kasssubek J, Landwehrmyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutnik P, Höglinger P, Jamrozik Z, Jellinger JA, Kazantsev A, Kretzschmar H, Lang AE, Litvan I, Lucas JJ, McGeer PL, Melquist S, Oertel W, Otto M, Paviour D, Reum T, Saint-Raymond A, Steele JC, Tolnay M, Tumani H, van Swieten JC, Vanier MT, Vonsattel JP, Wagner S, Wszolek ZK, & Reisensburg Working Group for Tauopathies with Parkinsonism (2009)
Tauopathies with Parkinsonism: clinical spectrum, neuropatholgic basis, biological markers, and treatment options.
Eur J Neuol 16:297-309
Meissner B, Kallenberg K, Sanchez-Juan P, Ramljak S, Krasnianski A, Heinemann U, Gelpi E, Barsic B, Kretzschmar HA, Schulz-Schaeffer WJ, Knauth M, & Zerr I. (2009)
MRI and clinical syndrome in dura mater-related Creutzfeldt-Jakob disease.
J Neurol 256:355-363
Mitteregger G, Korte S, Herms J, & Kretzschmar HA. (2009)
Role of copper and manganese in prion disease progression.
Brain Res. 2009 Oct 6;1292:155-64. Epub 2009 Jul 25.
weiter Abstract (PDF)
Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, & Lee VM. (2009)
Phosphorylation of S409/410 of TDP-43 is a consisten feature in all sporadic and familial forms of TDP-43 protinopathies.
Acta Neuropathol 117:137-149
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, & Mackenzie IR (2009)
Frontotemporal lobar degeneration with FUS pathology.
Brain [Epub ahead of print]
Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, & Mackenzie IR (2009)
Abundant FUS-immunoreactive pathology in neural intermediate filament inclusion disease.
Acta Neuropath [Epub ahead of print]
Notari S, Schimmel H, Budka H, Ferrer I, Haik S, Hauw JJ, Head MW, Ironside JW, Limido I, Rodriguez A, Ströbel T, Tagliavin F, & Kretzschmar HA (2009)
Inter-laboratory assessment of PrPSc typing in Creutzfeldt-Jakob disease. A Western blot study within the NeuroPrion consortium.
Brain Pathol 19:384-391
Opherk C, Duering M, Peters N, Karpinska A, Rosner S, Schneider E, Bader B, Giese A, & Dichgans M (2009)
CADASIL mutations enhance spontaneous multimerization ofNOTCH3.
Hum Mol Genet. 2009 Aug 1;18(15):2761-7.
Fossum E, Friedel CC, Rajagopala SV, Titz B, Baiker A, Schmidt T, Stellberger T, Rutenberg C, Suthram S, Bandyopadhyay S, Rose D, von Brunn A, Uhlmann M, Zeretzke C, Dong YA, Boulet H, Koegl M, Bailer SM, Koszinowski U, Ideker T, Uetz P, Zimmer R, & Haas J (2009)
Evolutionarily conserved herpesviral protein interaction networks.
PLoS Pathog. 2009 Sep;5(9):e1000570. doi: 10.1371/journal.ppat.1000570. Epub 2009 Sep 4.
Parchi P, Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, Zerr I, Roncaroli F, Cras P, Ghetti B, Pocchiari M, Kretzschmar H, & Capellari S. (2009)
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrP(Sc) types: an updated classification.
Acta Neuropathol. 2009.
Pflanz H, Vana K, Mitteregger G, Renner-Müller I, Pace C, Küchenhoff H, Kretzschmar HA, Wolf E, & Weiss S. (2009)
Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.
J Biol. 2009 May 15;388(4):721-9. Epub 2009 Mar 24.
weiter Abstract (PDF)
Pflanz H, Vana K, Mitteregger G, Pace C, Messow D, Sedlaczek C, Nikles D, Kretzschmar HA, & Weiss SF (2009)
Microinjection of lentiviral vectors expressing small interfering RNAs directed against laminin receptor precursor mRNA prolongs the pre-clinical phase in scrapie- infected mice.
J GenVorol 90:269-274
Priller C, Mitteregger G, Paluch S, Vassallo N, Staufenbiel M, Kretzschmar HA, Jucker, & Herms J. (2009)
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.
Neurobiol Aging 30:1227-37
Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn J.C, & Kreth F.W. (2009)
Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only.
Neurosurg. Psychiatry 80:1134-9
Schnell O, Krebs B, Carlsen J, Miederer I, Goetz C, Goldbrunner RH, Wester HJ, Haubner R, Pöpperl G, Holtmannspötter M, Kretzschmar HA, Kessler H, Tonn JC, Schwaiger M, & Beer AJ. (2009)
Imaging of integrin avb3 expression in patients with malignant glioma by [18F] galacto-RGD position emission tomography.
Neuro Oncol [Epub ahead of print]
Tang Y, Xiang W, Hawkins SA, Kretzschmar HA, & Windl O. (2009)
Transcriptional changes in the brain of cattle orally infected with BSE precede detection of infectivity.
J Virol [Epub ahead of print]
Winkler F, Kienast Y, Fuhrmann M, von Baumgarten L, Burgold S, Mitteregger G, Kretzschmar HA, & Herms J. (2009)
Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis.
Glia. 2009 Sep;57(12):1306-15.
weiter Abstract (PDF)
Wolschner C, Giese A, Kretzschmar HA, Huber R, Moroder L, & Budisa N (2009)
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7756-61.
Wüllner U, Schmitt I, Kammal M, Kretzschmar HA, & Neumann M. (2009)
Definite multiple system atrophy in a German family.
J Neurol Neurosurg Psychiatry 80:449-450
nach oben

2008

Sostak P, Padovan CS, Roeber, S, Segerer S, Schankin C, Siegert S, Saam T, Kolb HJ, Theil D, Kretzschmar HA, & Straube A (2008)
Cerebral angiitis in four patients with chronic GVHD
Bone Marrow Transplant. 2009 Nov 16.(Epub ahead of print)PMID: 19915632
Thon N, Ruiter, M., Mehrkens JH, Kreth S, Tonn JC, Kretzschmar HA, & Kreth FW (2008)
Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1q/19q and TP53 mutations in World Health Organization grade II gliomas
J Neuropathol Exp Neurol. 2009 Nov;68(11):1219-28
von Baumgarten L., Trabold R, Thal S, Back T, & Plesnila N (2008)
Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice.
J Cereb Blood Flow Metab. 2008 Juli;28(7):1353-60. Epub 2008 Apr 16.PMID:
Müller T, Jung K, Ullrich A, Schrötter A, Meyer HE, Stephan C, Egensperger R, & Marcus K (2008)
Disease state, age, sex, and post-mortem time-dependent expression of proteins in AD vs. control frontal cortex brain samples.
Curr Alzheimer Res 5(6):562-71 (2008).
Yang ZJ, Ellis T., Markant SL, Read TA, Kessler JD, Bourboulas M, Machold R, Fishell G, Rowitch DH, Wainwright BJ, & Wechsler-Reya RJ (2008)
Brain tumors can arise from lineage-restricted progenitors or stem cells.
Cancer Cell 14, 135-145.
Hoche F, Seidel K, Brunt ER, Auburger G, Schöls J, Bürk K, de Vos RA, den Dunnen W, Bechmann I, Egensperger R, Van Broeckhoven C, Gierga K, Deller T, & Rüb U (2008)
Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7).
Neuropathol Appl Neurobiol 34(5):479-91 (2008).
Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H, Bugiani O, Del-Tredici K, Ferrer I, Gelpi E, Giaccone G, Graeber MB, Ince P, Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Tagliavini F, Stadelmann C, Streichenberger N, Thal DR, Wharton SB, & Kretzschmar HA (2008)
Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium.
Brain Pathol. 2008 Mar 26.
Alafuzoff I, Parkkinen L, Al-Sarraj S, Arzberger T, Bell J, Bodi I, Bogdanovic N, Budka H, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D, Monoranu C, Morris J, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Streichenberger N, Thal DR, & Kretzschmar HA (2008)
BrainNet Europe Consortium. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium.
J Neuropathol Exp Neurol. 2008 Feb;67(2):125-43
Alafuzoff I, Pikkarainen M, Arzberger T, Thal DR, Al-Sarraj S, Bell J, Bodi I, Budka H, Capetillo-Zarate E, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Stadelmann C, Streichenberger N, Tagliavini F, & Kretzschmar HA (2008)
Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium.
Acta Neuropathol. 2008 May;115(5):533-46.
Bell JE, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Budka H, Dexter DT, Falkai P, Ferrer I, Gelpi E, Gentleman SM, Giaccone G, Huitinga I, Ironside JW, Kliouvea N, Kovacs GG, Meyronet D, Palkovits M, Parchi P, Patsouris E, Reynolds R, Riederer P, Roggendorf W, Seilhean D, Schmitt A, Schmitz P, Streichenberger N, Schwalber A, & Kretzschmar HA (2008)
Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium.
Acta Neuropathol. 2008 May;115(5):497-507.
Bojarski L, Herms J, & Kuznicki J (2008)
Calcium dysregulation in Alzheimer's disease.
Neurochem Int. 2008 Mar-Apr;52(4-5):621-33.
Brechlin P, Jahn O, Steinacker P, Cepek L, Kratzin H, Lehnert S, Jesse S, Mollenhauer B, Kretzschmar HA, Wiltfang J, & Otto M. (2008)
Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease.
Proteomics 8:4357-4366
Crecelius AC, Helmstetter D, Mitteregger G, Fröhlich T, Arnold GJ, & Kretzschmar HA (2008)
The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice.
Neuroreport. 2008 Jul 2;19(10):1027-31.
Crecelius A, Götz A, Arzberger T, Fröhlich T, Arnold GJ, Ferrer I, & Kretzschmar HA (2008)
Assessing quantitative post-mortem changes in the gray matter of the human frontal cortex proteome by 2-D DIGE.
Proteomics. 2008 Mar;8(6):1276-91.
Friedrich M, Körte R, Portero C, Arzberger T, Kretzschmar HA, Zerr I, & Nacimiento W (2008)
Fatal familial insomnia--a rare differential diagnosis in dementia.
Fortschr Neurol Psychiatr. 2008 Jan;76(1):36-40.
Grau S.J, Trillsch F, von Lüttichau I, Nelson P.J, Herms J, Tonn J.C, & Goldbrunner R.H (2008)
Lymphatic phenotype of tumor vessels in malignant gliomas.
Neuropath. Appl. Neurobiol. 34:675-9.
Heinemann U, Krasninaski A, Meissner B, Kallenberg K, Kretzschmar HA, Schulz-Schaeffer W, & Zerr I. (2008)
Brain biopsy inpatients with suspected Creutzfeldt-Jakob disease.
J Neurosurg 109:735-741
Heiseke A, Schöbel S, Lichtenthaler SF, Vorberg I, Groschup MH, Kretzschmar HA, Schätzl HM, & Nunziante M (2008)
The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
Traffic. 2008 Jul;9(7):1116-29. Epub 2008 Apr 18.
Kostka M, Högen T, Danzer KM, Levin J, Habeck M, Wirth A, Wagner R, Glabe CG, Finger S, Heinzelmann U, Garidel P, Duan W, Ross CA, Kretzschmar HA, & Giese A (2008)
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
J Biol Chem. 2008 Apr 18;283(16):10992-1003.
Kovacs GG, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Capellari S, Ferrer I, Gelpi E, Kövari V, Kretzschmar H, Nagy Z, Parchi P, Seilhean D, Soininen H, Troakes C, & Budka H. (2008)
Mixed brain pathologies in dementia: The BrainNet Europe consortium Experience.
Dement Geriatr Cogn Disord 26:343-350
Krasnianski A, Bartl M, Sanchez Juan PJ, Heinemann U, Meissner B, Varges D, Schulze-Sturm U, Kretzschmar HA, Schulz-Schaeffer WJ, & Zerr I (2008)
Fatal familial insomnia: Clinical features and early identification.
Ann Neurol. 2008 May;63(5):658-61.
Krasnianski A, Kallenberg K, Collie DA, Meissner B, Schulz-Schaeffer WJ, Heinemann U, Varges D, Summers DM, Kretzschmar HA, Talbot T, Will RG, & Zerr I (2008)
MRI in the classical MM1 and the atypical MV2 subtypes of sporadic CJD: an inter-observer agreement study.
Eur J Neurol. 2008 Aug;15(8):762-71.
Kühnlein P, Sperfeld AD, Vanmassenhove B, Van Deerlin V, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph AC, & Neumnn M (2008)
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP Mutations.
Arch Neurol 65:1185-1189
Linn J, Herms J, Dichgans M, Bruckmann H, Fesl G, Freilinger T, & Wiesmann M. (2008)
Subarachnoid hemosiderosis and superficial cortical hemosiderosis in cerebral amyloid angiopathy
Am. J. Neuroradiol. 29:184-6.
Mehrkens JH, Pöpperl G, Rachinger W, Herms J, Seelos K, Tatsch K, Tonn JC, & Kreth FW (2008)
The positive predictive value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET in the diagnosis of a glioma recurrence after multimodal treatment.
J Neurooncol. 2008 May;88(1):27-35.
Mittelbronn M, Capper D, Bader B, Schittenhelm J, Haybaeck J, Meyermann R, Kretzschmar HA, & Wietholter H (2008)
Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease.
Folia Neuropathol. 2008;46(2):149-53.
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, & Schlossmacher MG (2008)
Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration.
Exp Neurol. 2008 Jun 14.
Müller T, Meyer HE, Egensperger R, & Marcus K. (2008)
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease.
Prog Neurobiol. 2008 Aug;85(4):393-406. Epub 2008 Jul 7. Review.
weiter Abstract (PDF)
Notari S, Strammiello R, Capellari S, Giese A, Cescatti M, Grassi J, Ghetti B, Langeveld JP, Zou WQ, Gambetti P, Kretzschmar HA, & Parchi P (2008)
Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease.
J Biol Chem 283:30557-30565
Parchi P, Notari S, Schimmel H, Budka H, Ferrer I, Haik S, Hauw JJ, Head MW, Ironside JW, Limido L, Rodriguez A, Ströbel T, Tagliavini F, & Kretzschmar HA (2008)
Inter-Laboratory Assessment of PrP(Sc) Typing in Creutzfeldt-Jakob Disease: A Western Blot Study within the NeuroPrion Consortium.
Brain Pathol. 2008 Jul 2.
Roeber S, Windl O, Krebs B, Xiang W, Vollmert C, Illig T, Schröter A, Arzberger T, Zerr I, & Kretzschmar HA (2008)
Evidence for a pathogenic role of different mutations at codon 188 of PRNP.
PLoS ONE. 2008 May 14;3(5):e2147.
Roeber S, Mackenzie IR, Kretzschmar HA, & Neumann M (2008)
TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.
Acta Neuropathol. 2008 Aug;116(2):147-57. Epub 2008 Jun 7.
Schmalzbauer R, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, & Kretzschmar HA (2008)
Evidence for an association of prion protein and sphingolipid-mediated signaling
J Neurochem. 2008 Aug;106(3):1459-70. Epub 2008 Jun 28.
Schnell O, Krebs B, Wagner E, Romagna A, Beer AJ, Grau SJ, Thon N, Goetz C, Kretzschmar HA, Tonn JC, & Goldbrunner RH (2008)
Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature.
Brain Pathol. 2008 Jul;18(3):378-86. Epub 2008 Apr 2.
Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, & Ligon KL (2008)
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer Cell 14, 123-134.
Ruiter M, Kretzschmar HA, & Herms J (2008)
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas.
Acta Neuropathol 115(3):367-8
Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HK, Ludolph A, Neumann M, & Otto M (2008)
TDP-43 in cerebrospinal fluid of patients wih frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Arch Neurol 65:1481-1487
Stummer W, Beck T, Beyer W, Mehrkens JH, Obermeier A, Etminan N, Stepp H, Tonn JC, Baumgartner R, Herms J, & Kreth FW (2008)
Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report.
J Neurooncol. 2008 Mar;87(1):103-9.
Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossmann M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, & Neumann M (2008)
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
J Neuropathol Exp Neurol. 2008 Jun;67(6):555-64.
Reznicek L, Mitteregger G, Kretzschmar HA, & Giese A (2008)
Differential effects of prion particle size on infectivity in vivo and in vitro. Biochem Biophys Res Commun.
2008 May 9;369(3):924-8.
Zuber C, Mitteregger G, Schuhmann N, Rey C, Knackmuss S, Rupprecht W, Reusch U, Pace C, Little M, Kretzschmar HA, Hallek M, Büning H, & Weiss S (2008)
Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy.
J Gen Virol. 2008 Aug;89(Pt 8):2055-61.
nach oben

2007

Müller T, Concannon CG, Ward MW, Walsh CM, Tirniceriu AL, Tribl F, Kögel D, Prehn JHM, & Egensperger R (2007)
Modulation of gene expression and cytoskeletal dynamics by the APP intracellular domain (AICD).
Mol Biol Cell 18:201-210 (2007).
Koch A., Hrychyk A., Hartmann W., Waha A., Mikesa T., Waha A., Sörensen N., Berthold F., Goodyear C.G., Wiestler O.D., Birchmeier W., Behrens J., & Pietsch T. (2007)
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.
Int J Cancer, 121(2):284-91.
Friedel R.H., Kerjan G., Rayburn H., Sotelo C., Tessier-Lavigne M., & Chédotal A. (2007)
PlexinB2 controls the development of cerebellar granule cells.
J Neurosci, 27(14):3931-32.
Notari S, Capellari S, Langefeld J, Giese A, Strammiello R, Gambetti P, Kretzschmar HA, & Parchi P (2007)
A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule.
Lab Invest (2007) 87: 1103-1112.
Wagner I, Sethi S, Xiang W, Giese A, Ebner S, & Kretzschmar HA (2007)
Repeated peripheral administrations of CpG oligodeoxynucleotides lead to sustained CNS immune activation.
Immunopharmacol Immunotoxicol (2007) 29: 413-424.
Plesnila N, von Baumgarten L, Retiounskaia M, Engel D, Ardeshiri A, Zimmermann R, Hoffmann F, Landshamer S, Wagner E, & Culmsee C (2007)
Delayed neuronal death after brain trauma invilves p53-dependent inhibition of NF-kappaB transcriptional acitivity.
Cell Death Differ. 2007 Aug;14(8):1529-41. Epub 2007 Apr 27.PMID: 17464322 Shared first authorship.
Danzer KM, Haasen D, Karow AL, Moussaud S, Habeck M, Giese A, Kretzschmar HA, Hengerer B, & Kostka M (2007)
Different species of alpha synuclein oligomers induce calcium influx and seeding.
J Neurosci (2007) 27: 9220-9232.
Cepek L, Brechlin P, Steinacker P, Mollenhauer B, Klingebiel E, Bibl M, Kretzschmar HA, Wiltfang J, & Otto M (2007)
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Dement Geriatr Cogn Disord 23(1) :22-8
Del Pino P, Weiss A, Bertsch U, Renner C, Mentler M, Grantner K, Fiorino F, Meyer-Klaucke W, Moroder L, & Parak F. G (2007)
The configuration of the Cu(2+) binding region in full-length human prion protein.
Eur Biophys J. 36(3): 239-52
Ferrer I, Armstrong J, Capellari S, Parchi P, Arzberger T, Bell J, Budka H, Strobel T, Giaccone G, Rossi G, Bogdanovic N, Fakai P, Schmitt A, Riederer P, Al-Sarraj S, Ravid R, & Kretzschmar HA (2007)
Effects of Formalin Fixation, Paraffin Embedding, and Time of Storage on DNA Preservation in Brain Tissue: A BrainNet Europe Study.
Brain Pathol, Apr 30
Ferrer I, Santpere G, Arzberger T, Bell J, Blanco R, Boluda S, Budka H, Carmona M, Giaccone G, Krebs B, Limido L, Parchi P, Puig B, Strammiello R, Strobel T, & Kretzschmar HA (2007)
Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study.
J Neuropathol Exp Neurol.-66(1): 35-46
Fuhrmann M, Mitteregger G, Kretzschmar H, & Herms J. (2007)
Dendritic pathology in prion disease starts at the synaptic spine.
J. Neurosci. 27:6224-6233.
Kreth FW, Ruiter M, Schnell O, Bise K, Felsberg J, Reifenberger G, Tonn JC, & Kretzschmar HA (2007)
Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas.
Int J Cancer. 2007 Dec 1;121(11):2458-64.
Grau S.J, Trillsch E, Herms J, Thon N, Nelson P.J, Tonn J.C, & Goldbrunner R. (2007)
Expression of VEGFR3 in glioma endothelium correlates with tumor grade.
J. Neuroconcol. 82:141-50.
Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhoevd C, Reichert A, Kretzschmar H.A, Haass C, & Herms J (2007)
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.
J. Neurochem. 102:1264-75.
Heinemann U, Krasnianski A, Meissner B, Varges D, Kallenberg K, Schulz-Schaeffer W. J, Steinhoff B. J, Kretzschmar HA, & Zerr I (2007)
Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillance.
Brain 130 (5), 1350-9.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Onodera T, Kretzschmar H, & Herms J. (2007)
The cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
J. Neurochem. 100:358-67.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Mitteregger G, Onodera T, Kretzschmar HA, & Herms J (2007)
Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
J Neurochem 110, 2: 358-367
Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nolting S, Hamann G. F, & Kretzschmar HA (2007)
The role of the octarepeat region in neuroprotective function of the cellular prion protein.
Brain Pathol 17(2):174-83
Neumann M, Igaz L. M, Kwong L. K, Nakashima-Yasuda H, Kolb S. J, Dreyfuss G, Kretzschmar HA, Trojanowski J. Q, & Lee V. M (2007)
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta Neuropathol (Berl) Apr 6
Neumann M, Kwong L. K, Truax A. C, Vanmassenhove B, Kretzschmar HA, Van Deerlin V. M, Clark C. M, Grossman M, Miller B. L, Trojanowski J. Q, & Lee V. M (2007)
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
J Neuropathol Exp Neurol 66(3): 177-83
Neumann M, Mackenzie I. R, Cairns N. J, Boyer P. J, Markesbery W. R, Smith C. D, Taylor J. P, Kretzschmar HA, Kimonis V. E, & Forman M. S (2007)
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
J Neuropathol Exp Neurol 66(2): 152-7
Popperl G, Kreth F.W, Mehrkens J.H, Herms J, Seelos K, Koch W, Gildehaus F.J, Kretzschmar H.A, Tonn J.C, & Tatsch K. (2007)
FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading.
Eur J Nucl Med Mol Imaging 34(12):1933-1942
Priller C, Dewachter I, Vassallo N, Pace C, Kretzschmar H, van Leuven F, & Herms J. (2007)
Mutant Presenilin 1 alters synaptic transmission in cultured hippocampal neurons.
J. Biol. Chem. 282:1119-27.
Ring S, Weyer S, Kilian S, Waldron E, Pietrzik C.U, Filippov M, Herms J, Eckman C.B, Korte M, Wolfer D.P, & Müller U. (2007)
The secreted APPsa domain is sufficient to rescue the anatomical, behavioural, and electrophysiological abnormalities of APP deficient mice.
J. Neurosci. 27:7817-26.
Schiffer N. W, Broadley S. A, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl F. U, & Schmid B (2007)
Identification of Anti-prion Compounds as Efficient Inhibitors of Polyglutamine Protein Aggregation in a Zebrafish Model.
J Biol Chem 282, 12: 9195-203
Rowitch D.H (2007)
beta-catenin is required for cerebellar morphogenesis.
Brain Res, 1140, 161-169
Zhao Q, Godhino S, Heine V, Medema R, Pellman D, & Rowitch D (2007)
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors
Mol Cell Biol, 27(23):8259-70
Seitz R, von Auer F, Blumel J, Burger R, Buschmann A, Dietz K, Heiden M, Hitzler W. E, Klamm H, Kreil T, Kretzschmar HA, Nubling M, Offergeld R, Pauli G, Schottstedt V, Volkers P, & Zerr I (2007)
Impact of vCJD on blood supply.
Biologicals 35(2): 79-97
Sethi S, Kerksiek K. M, Brocker T, & Kretzschmar HA (2007)
Role of the CD8+ dendritic cell subset in transmission of prions.
J Virol, epub ahead of print Feb 14
Sostak P, Theil D, Stepp H, Roeber S, Kretzschmar HA, & Straube A (2007)
Detection of bone marrow-derived cells expressing a neural phenotype in the human brain.
J Neuropathol Exp Neurol. 66(2):110-116
Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M, & Kretzschmar HA (2007)
Generation of genuine prion infectivity by serial PMCA.
Vet Microbiol.
Weiss A, Del Pino P, Bertsch U, Renner C, Mentler M, Grantner K, Moroder L, Kretzschmar HA, & Parak FG (2007)
The configuration of the Cu(2+) binding region in full-length human prion protein compared with the isolated octapeptide.
Vet Microbiol, Apr 8.
Xiang W, Hummel M, Mitteregger G, Pace C, Windl O, Mansmann U, & Kretzschmar HA (2007)
Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model.
J Neurochem , Apr 16
nach oben

2006

Riemenschneider M, Konta L, Friedrich P, Schwarz S, Taddei K, Neff F, Padovani A, Kölsch H, Laws SM, Klopp N, Bickeböller H, Wagenpfeil S, Mueller JC, Rosenberger A, Diehl-Schmid J, Archetti S, Lautenschlager N, Borroni B, Müller U, Illig T, Heun R, Egensperger R, Schlegel J, Förstl H, Martins RN, & Kurz A (2006)
A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer’s disease.
Hum Mol Genet 15 (16): 2446-56 (2006).
Jeibmann A, Hasselblatt M, Gerss J, Wrede B, Egensperger R, Beschorner R, Hans VH, Rickert CH, Wolff JE, & Paulus W (2006)
Prognostic implications of atypical histologic features in choroid plexus papilloma.
J Neuropathol Exp Neurol 65 (11): 1069-73 (2006).
Alafuzoff I, Pikkarainen M, Al-Sarraj S, Arzberger T, Bell J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Ferrer I, Gelpi E, Giaccone G, Graeber M. B, Hauw J. J, Kamphorst W, King A, Kopp N, Korkolopoulou P, Kovacs G. G, Meyronet D, Parchi P, Patsouris E, Preusser M, Ravid R, Roggendorf W, Seilhean D, Streichenberger N, Thal D. R, & Kretzschmar H (2006)
Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium.
J Neuropathol Exp Neurol 65 (8), 740-57.
Barnewitz K, Maringer M, Mitteregger G, Giese A, Bertsch U, & Kretzschmar H. A. (2006)
Unaltered prion protein cleavage in plasminogen-deficient mice.
Neuroreport 17 (5): 527-30
Behrends C, Langer C. A, Boteva R, Bottcher U. M, Stemp M. J, Schaffar G, Rao B. V, Giese A, Kretzschmar HA, Siegers K, & Hartl F. U (2006)
Chaperonin TRiC Promotes the Assembly of polyQ Expansion Proteins into Nontoxic Oligomers.
Mol Cell 23 (6), 887-97.
Boesenberg-Grosse C, Schulz-Schaeffer W. J, Bodemer M, Ciesielczyk B, Meissner B, Krasnianski A, Bartl M, Heinemann U, Varges D, Kretzschmar HA, Green A, & Zerr I (2006)
Brain-derived proteins in the CSF: do they correlate with brain pathology in CJD?
BMC Neurol, 6: 35.
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, & Del Tredici K (2006)
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.
Acta Neuropathol (Berlin) published on Aug 12
Buerger K, Otto M, Teipel S. J, Zinkowski R, Blennow K, DeBernardis J, Kerkman D, Schroder J, Schonknecht P, Cepek L, McCulloch C, Moller H. J., Wiltfang J, Kretzschmar HA, & Hampel H. (2006)
Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease.
Neurobiol Aging 27 (1): 10-15
Collins S. J, Sanchez-Juan P, Masters C. L, Klug G. M, van Duijn C, Poleggi A, Pocchiari M, Almonti S, Cuadrado-Corrales N, de Pedro-Cuesta J, Budka H, Gelpi E, Glatzel M, Tolnay M, Hewer E, Zerr I, Heinemann U, Kretszchmar H. A, Jansen G. H, Olsen E, Mitrova E, Alperovitch A, Brandel J. P, Mackenzie J, Murray K, & Will R.G (2006)
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease.
Brain, published on Jul 1, (2006)
de Silva R, Lashley T, Strand C, Shiarli A. M, Shi J, Tian J, Bailey K. L, Davies P, Bigio E. H, Arima K, Iseki E, Murayama S, Kretzschmar HA, Neumann M, Lippa C, Halliday G, Mackenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown S. M, Holton J, Lees A, Revesz T, & Mann D. M (2006)
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies.
Acta Neuropathol (Berl) 111(4): 329 -340
Freichel C, Neumann M, Ballard T, Muller V, Woolley M, Ozmen L, Borroni E, Kretzschmar H, Haass C, Spooren W, & Kahle P. J (2006)
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.
Neurobiol Aging, published on Jul 25
Frohlich T, Helmstetter D, Zobawa M, Crecelius A. C, Arzberger T, Kretzschmar HA, & Arnold G. J (2006)
Analysis of the HUPO Brain Proteome reference samples using 2-D DIGE and 2-D LC-MS/MS.
Proteomics 6(18), 4950-66.
Fuhrmann M, Bittner T., Mitteregger G, Haider N, Moosmang S, Kretzschmar H, & Herms J. (2006)
Loss of the cellular prion protein affects the Ca(2+) homeostasis in hippocampal CA1 neurons.
J Neurochem 98 (6), 1876-85.
Fuhrmann M, Mitteregger G, Moosmang S, Kretzschmar H, & Herms J. (2006)
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.
J. Neurochem. 98:1876-85.
Hamacher M, Apweiler R, Arnold G, Becker A, Bluggel M, Carrette O, Colvis C, Dunn M. J, Frohlich T, Fountoulakis M, van Hall A, Herberg F, Ji J, Kretzschmar HA, Lewczuk P, Lubec G, Marcus K, Martens L, Palacios Bustamante N, Park Y. M, Pennington S. R, Robben J, Stuhler K, Reidegeld K. A, Riederer P, Rossier J, Sanchez J. C, Schrader M, Stephan C, Tagle D, Thiele H, Wang J, Wiltfang J, Yoo J. S, Zhang C, Klose J, & Meyer H. E. (2006)
HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy.
Proteomics 6 (18) 4890 - 8 .
Krasnianski A, Meissner B, Schulz-Schaeffer W, Kallenberg K, Bartl M, Heinemann U, Varges D, Kretzschmar H. A, & Zerr I (2006)
Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt-Jakob disease.
Arch Neurol, 63, 6: 876-80
Krasnianski A, Schulz-Schaeffer W., Kallenberg K, Meissner B, Collie D. A, Roeber S, Bartl M, Heinemann U, Varges D, Kretzschmar H. A, & Zerr I (2006)
Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD.
Brain, published on May 23, 2006
Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, & Kretzschmar H.A. (2006)
Prion protein induced signaling cascades in monocytes.
Biochem Biophys Res Commun 340 (1):13-22
Krebs B, Kohlmannsperger V, Nolting S, Schmalzbauer R, & Kretzschmar H.A. (2006)
A Method to Perform Western Blots of Microscopic Areas of Histological Sections.
J Histochem.Cytochem.
Neumann M, Sampathu D. M, Kwong L. K, Truax A. C, Micsenyi M. C, Chou T. T, Bruce J, Schuck T, Grossman M, Clark C. M, McCluskey L. F, Miller B. L, Masliah E, Mackenzie I. R, Feldman H, Feiden W, Kretzschmar HA, Trojanowski J. Q, & Lee V. M (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science 314, 5796:130 -3
Pfeifer A, Al-Khadra S, Hofmann A, Mitteregger G, Moser M, Bertsch U, & Kretzschmar HA (2006)
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice.
J Clin Invest 116, 12: 3204-3210
Piening N, Nonno R, Di Bari M, Walter S, Windl O, Agrimi U, Kretzschmar HA, & Bertsch U (2006)
Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo.
J Biol Chem.
Piening N, Hogen T, Beekes M, Kretzschmar H, & Giese A. (2006)
Photo-induced crosslinking of prion protein oligomers and prions.
Amyloid 13 (2), 67 -77
Popperl G, Kreth F. W, Herms J, Koch W, Mehrkens J. H, Gildehaus F. J, Kretzschmar H. A, Tonn J. C, & Tatsch K (2006)
Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?
J Nucl Med 47 (3): 393-403
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, & Herms J (2006)
Synapse formation and function is modulated by the amyloid precursor protein.
J Neurosci 26 (27): 7212-21
Roeber S, Bazner H, Hennerici M, Porstmann R, & Kretzschmar H. A. (2006)
Neurodegeneration with Features of NIFID and ALS-Extended Clinical and Neuropathological Spectrum.
Brain Pathol 16(3), 228-34
Kho A.T, Zhao Q, Ma Q, & Rowitch D.H. (2006)
Cerebellar ‚transcriptome’ reveals cell-type and stage-specific expression during postnatal development and tumorigenesis (2006).
Mol Cell Neurosci, 33(3), 247-59.
Shiarli A. M, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio E. H, Ghetti B, Murrell J. R, Delisle M. B, Mirra S, Crain B, Zolo P, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown S. M, & Mann D. M (2006)
Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease.
Neuropathol Appl Neurobiol 32 (4), 374 - 387.
Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeboller H, Illig T, KORA group, & Kretzschmar HA (2006)
Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study.
J Med Genet. 2006 Oct;43(10):e53.
Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M, & Kretzschmar HA (2006)
Cell-free formation of misfolded prion protein with authentic prion infectivity.
Proc Natl Acad Sci U S A 103, 43: 15818-23
Wermke M, Teipel S, Fuchsberger T, Kretzschmar HA, Westner I, Schroder M, Hampel H, & Drzezga A. (2006)
Frontal diaschisis in a German case of fatal familial insomnia.
J Neurol. epub ahead of print Oct 13, 2006
nach oben

2005

Hartmann W., Koch A., Brune H., Waha A., Dani I, Denkhaus D., Langmann W., Bode U., Wiestler O.D., Schilling K., & Pietsch T. (2005)
Insulin-like growth factor II is involved in the proliferation control of medullablastoma and its cerebellar percursor cells.
Am J Pathol, 166(4), 1153-62
Koch A., Waha A., Hartmann W., Hrychyk A., Wharton K.A., Fuch S.Y., von Schweinitz D., & Pietsch T. (2005)
Elevated transcriptional activity of Wnt antagonists is a common event in hepatoblastomas.
Clin Cancer Res, 11(12), 4295-4304.
Bertsch U, Winklhofer K.F, Hirschberger Th, Bieschke J, Hartl F.U, Tavan P, Tatzelt J, Kretzschmar HA, & Giese A. (2005)
Systematic identification of anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets.
J Virol 79, 7785-7791.
Bleich S, Otto M, Zerr I, Kropp S, Kretzschmar HA, & Wiltfang J (2005)
Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid.
Gerontology. 51:142-144
Boesenberg C, Schulz-Schaeffer W. J, Meissner B, Kallenberg K, Bartl M, Heinemann U, Krasnianski A, Stoeck K, Varges D, Windl O, Kretzschmar H.A, & Zerr I (2005)
Clinical course in young patients with sporadic Creutzfeldt-Jakob disease.
Ann.Neurol. 58 (4):533-543.
Giese A., Bader B, Bieschke J, Schaffar G, Odoy S, Kahle Ph, Haass Ch, & Kretzschmar HA (2005)
Single particle detection and characterization of synuclein co-aggregation.
Biochem. Biophys. Res. Commun. 333, 1202 - 1210
Giese A, Buchholz M, Herms J, & Kretzschmar H. (2005)
Mouse brain synaptosomes efficiently accumulate copper-67 by two distinct processes independent of cellular prion protein.
J. Molecular Neurosci. 27:347-54.
Jacobi C, Arlt S, Reiber H, Westner I, Kretzschmar HA, Poser S, & Zerr I (2005)
Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.
Acta Neurol Scand 111:185-190
Kovacs G.G, Puopolo M, Ladogana A, Pocchiari M, Budka H, van Duijn C, Collins S.J, Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N, Brandel J.P, Zerr I, Kretzschmar H.A, Pedro-Cuesta J, Calero-Lara M, Glatzel M, Aguzzi A, Bishop M, Knight R, Belay G, Will R, & Mitrova E (2005)
Genetic prion disease: the EUROCJD experience.
Hum.Genet. 118 (2):166-174.
Krebs B, Lederer R.M, Windl O, Zerr I, & Kretzschmar H.A. (2005)
Creutzfeldt-Jakob disease associated with an R148H mutation of the prion protein gene.
Neurogenetics: 97-100
Ladogana A, Puopolo M, Croes EA, Budka H, Jarius C, Collins S, Klug GM, Sutcliffe T, Giulivi A, Alperovitch A, Delasniere-Laupretre N, Brandel J-P, Poser S, Kretzschmar H, Rietveld I, Mitrova E, de Pedro Cuesta J, Martinez-Martin P, Glatzel M, Aguzzi A, Knight R, Ward H, Pocchiari M, van Duijn CM, Will RG, & Zerr I (2005)
Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia and Canada.
Neurology 64:1586-1591
Levin J, Bertsch U, Kretzschmar H, & Giese A. (2005)
Single particle analysis of manganese-induced prion protein aggregates.
Biochem. Biophys. Res. Commun. 329, 1200-1207.
Meissner B, Westner I. M, Kallenberg   K, Krasnianski A, Bartl M, Varges D, Bosenberg C, Kretzschmar H. A, Knauth M, Schulz-Schaeffer W.J., & Zerr I (2005)
Sporadic Creutzfeldt-Jakob disease: clinical and diagnostic characteristics of the rare VV1 type.
Neurology 65 (10):1544-1550.
Mollenhauer B, Bibl M, Trenkwalder C, Stiens G, Cepek L, Steinacker P, Ciesielczyk B, Neubert K, Wiltfang J, Kretzschmar HA, Poser S, & Otto M (2005)
Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease.
J Neural Transm. 112 (7):933-948
Mollenhauer B, Cepek L, Bibl M, Wiltfang J, Schulz-Schaeffer WJ, Ciesielczyk B, Neumann M, Steinacker P, Kretzschmar HA, Poser S, Trenkwalder C, & Otto M (2005)
Tau protein, Abeta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies.
Dement Geriatr Cogn Disord. 19(2-3):164-70
Neumann M, Diekmann S, Bertsch U, Vanmassenhove B, Bogerts B, & Kretzschmar HA (2005)
Novel G335V mutation in the tau gene associated with early onset familial frontotemporal dementia.
Neurogenetics 2005 Mar 12
Neumann M, Mittelbronn M, Simon P, Vanmassenhove B, de Silva R, Lees A, Klapp J, Meyermann R, & Kretzschmar H.A (2005)
A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects.
Neuropathol.Appl.Neurobiol. 31 (4):362-373.
Perneczky R, Mösch D, Neumann M, Kretzschmar HA, Müller U, Busch R, Förstl H, & Kurz A (2005)
The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study.
Dementia Geriatr Cogn Disord 20:89-94  
Piening N, Giese A, & Kretzschmar HA (2005)
Breakage of PrP aggregates is essential for efficient autocatalytic propagation of misfolded prion protein.
Biochem Biophys Res Comm 326 (2005) 339-343
Rachinger W, Goetz C, Pöpperl G, Gildehaus F.J, Kreth F.W, Holtmannspötter M, Herms J, Koch W, Tatsch K, & Tonn J.C. (2005)
Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas.
Neurosurgery 57:505-11.
Roeber S, Krebs B, Neumann M, Windl O, Zerr I, & Kretzschmar HA (2005)
Creutzfeldt - Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17- kDa prion protein fragment.
Acta Neuropathol., published online March 01, 2005
Sarafoff N.I, Bieschke J, Giese A., Bertsch U, & Kretzschmar H.A. (2005)
Automated PrPres amplification using indirect sonication.
J Biochem Biophys Methods. 2005 Jun 30;63(3):213-21.
Schankin CJ, Birnbaum T, Linn J, Brunning R, Kretzschmar HA, Straube A, & Krebs B (2005)
A fatal encephalitis.
Lancet 365 (9456):358
Koch A, Hartmann W, Garré M.L, Goodyer C.G, Cama A, Sörensen N, Wiestler O.D, & Pietsch T (2005)
Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
Int J Cancer, 117:82-9.
Stork M, Giese A, Kretzschmar HA, & Tavan P (2005)
MD simulations indicate a possible role of parallel beta helices in seeded aggregation of poly-Gln.
Biophys J 2005
Tschampa H.J, Kallenberg K, Urbach H, Meissner B, Nicolay C, Kretzschmar H.A, Knauth M, & Zerr I  (2005)
MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement.
Brain 128 (Pt 9):2026-2033.
Uspenskaia O, Liebetrau M, Herms J, Danek A, & Hamann G.F. (2005)
Age-related changes of collagen type IV expression in human cerebral microvessels.
BMC Neuroscience 5:37
Vasallo N, Herms J, Behrens C, Krebs B, Windl O, & Kretzschmar H. (2005)
Activation of phosphatidylinositol 3-kinase by copper bound prion protein and its role in cell survival.
Biochem. Biophys. Res. Commun. 332:75-82.
Vassallo N, Herms J, Behrens C, Krebs B, Saeki K, Onodera T, Windl O, & Kretzschmar H.A. (2005)
Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival.
Biochem. Biophys. Res. Commun. 332, 75-82.
Weis E, Albrecht C.F, Herms J, Behnke-Mursch, Pekrun A, Brockmann K, & Hess C.F. (2005)
Malignant ectomesenchymoma of the cerebrum. Case report and discussion of therapeutic options.
Eur. J. Pediatr. 164:345-49.
Windl O, Buchholz M, Neubauer A, Schulz-Schaeffer W.J, Groschup M, Walter S, Arendt S, Neumann M, Voss A.K, & Kretzschmar H.A (2005)
Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy.
J Virol 79 (23):14971-14975.
Xiang W, Windl O, Westner I.M, Neumann M, Zerr I, Lederer R. M, & Kretzschmar H.A (2005)
Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.
Ann.Neurol. 58 (2):242-257
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2004

Banati RB, Egensperger R, Maassen A, Hager G, Kreutzberg GW, & Graeber MB (2004)
Mitochondria in activated microglia in vitro.
J Neurocytol 33 (5): 535-541 (2004).
Albrecht R, Krebs B, Reusche E, Nagel M, Lencer R, & Kretzschmar H. (2004)
Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Eur Arch Psychiatry Clin Neurosci Published online Nov 24
Bieschke J, Sarafoff N, Beekes M, Giese A, & Kretzschmar H. (2004)
Autocatalytic self-propagation of misfolded prion protein.
Proc Nat Acad Sci USA 101(33):12207-11
Drisaldi B, Coomaraswami J, Masrangelo P, Strome B, Yang J, Chishti MA, Windl O, Ahrens R, Major F, Kretzschmar H, Fraser PE, Mount HTJ, & Westaway D (2004)
Mapping activity determinants in cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
JBC 279:55443-554454
Giese A, Levin J, Bertsch U, & Kretzschmar H (2004)
Effect of metal ions on de novo aggregation of full length prion protein.
Biochem Biophys Res Comm 320 (4): 1240-1246
Lorenz H, Mann U, Nitsch R, Windl O, & Kretzschmar H.A. (2004)
Loss of glycosylation associated with the T183A mutation in human prion disease.
Acta Neuropath 108(6), 476 -484
Schmalzbauer R, Weber P, Krebs B, Windl O, Zerr I, & Kretzschmar H.A (2004)
A novel three extra-repeat insertion in the prion protein gene (PRNP) in a patient with Creutzfeldt-Jakob disease.
Neurogenetics online Nov 2004
Hampel H, Haslinger A, Scheloske M, Padberg F, Fischer P, Unger J, Teipel SJ, Neumann M, Rosenberg C, Oshida R, Hulette C, Pongratz D, Ewers M, Kretzschmar HA, & Moller HJ (2004)
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain.
Eur Arch Psychiatry Clin Neurosci Nov 26
Harder A, Gregor A, Wirth T, Kreuz F, Schulz-Schaeffer WJ, Windl O, Plotkin M, Amthauer H, Neukirch K, Kretzschmar HA, Kuhlmann T, Braas R, Hahane HH, & Jendroska K (2004)
Early age of onset in fatal familial insomnia.Two novel cases and review of the literature.
J Neurol 251:715-724
Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, & Müller U (2004)
Cortical Dysplasia Resembling Human Type 2 Lissencphaly in Mice Lacking all three APP-Family Members.
EMBO 23:4106-4115
Klunemann HH, Rogaeva E, Nemann M, Kretzschmar HA, Kandel M, Toulina A, Sato C, Salehi-Rad S, Pfister K, Klein HE, & St. George-Hyslop PH (2004)
Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease
Alzheimer Dis Assoc Disord 18 (4): 256-8
Meißner B, Köhler K, Körtner K, Bartl M, Jastrow U, Mollenhauer B, Schröter A, Finkenstaedt M, Windl O, Poser S, Kretzschmar HA, & Zerr I (2004)
Sporadic Creutzfeldt-Jakob disease: correlation of magnetic resonance imaging with clinical findings.
Neurology 10:450-456
Mentler M, Weiss A, Grantner K, del Pino P, Deluca D, Fiori S, Renner C, Meyer Klaucke W, Moroder L, Bertsch U, Kretzschmar HA, Tavan P, & Parak FG. (2004)
A new method to determine the structure of he metal environment in metalloproteins: Investigation of the prion protein octapeptide repeat Cu2+ complex.
Eur Biophys J Sept 2004
Neumann M, & Kretzschmar HA (2004)
Pathologie und Biochemie der frontotemporalen Demenzen
Nervenheilkunde; 2:73-79
Neumann M, Müller V, Görner K, Kretzschmar HA, Haass CH, & Kahle J (2004)
Pathological properties of the Parkinsons disease-associated protein DJ-1 in -synucleinopathies and tauopathies: relevance for multiple system atrophy and Picks disease.
Acta Neuropath ( Berlin) online publication
Neumann M, Müller V, Kretzschmar HA, Haass Ch, & Kahle P.J. (2004)
Regional Distribution of Proteinase K Resistant  a-Synuclein Correlates with Lewy Body Disease Stage.
JNEN 63 (12), 1225-1235 
Notari S, Capellari S, Giese A, Westner I, Baruzzi A, Ghetti B, Gambetti P, Kretzschmar H, & Parchi P (2004)
Effects of different experimental conditions on the PrP Sc core generated by protease digestion: Implications for strain typing and molecular classification.
J Biol Chem 279: 16797-16804
Otto M, Cepek L, Ratzka P, Doehlinger S, Boekhoff I, Wiltfang J, Irle E, Pergande G, Ellers-Lenz B, Windl O, Kretzschmar HA, Poser S, & Prange H (2004)
Efficacy of flupirtine on cognitive function in patients with CJD.
Neurology 62:714-718
Özen Ö, Krebs B, Hemmerlein B, Pekrun A, Kretzschmar H, & Herms J (2004)
Expression of matrix metalloproteinases and their inhibitors in medulloblastomas and their prognostic relevance.
Clinical CancerResearch. Clin Cancer Res 10:4746-4753
Peraud A, Herms J, Schlegel J, Müller P, Kretzschmar H, & Tonn J.-C. (2004)
Recurrent spinal cord astrocytoma with intraventrucular seeding.
Childs Nerv Syst 20:114-118
Petzold GC, Westner I, Bohner G, Einhäupl KM, Kretzschmar HA, & Valdueza JM (2004)
False-positive sign on MRI in sporadic Creutzfeldt-Jakob disease.
Neurology 62:1235-6
Pocchiari M, Puopolo M, Croes EA, Budka H, Gelpi E, Collins A, Lewis V, Sutcliffe T, Guilivi A, Delasniere-Laupretre N, Brandel J-N, Alperovitch A, Zerr I, Poser S, Kretzschmar HA, Ladogana A, Rietvald I, Mitrova E, Martinez-Martin P, de Pedro-Cuesta J, Glatzel M, Aguzzi A, Cooper S, Mackenzie J, van Dujin CM, & Will RG (2004)
Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. 
Brain 127: 2348-2359
Renner C, Fiori S, Fiorino F, Landgraf D, Deluca D, Mentler M, Grantner K, Parak FG, Kretzschmar H, & Moroder L (2004)
Comparative study of copper binding by the octapeptide repeat of the prion protein in aqueous and membrane mimetic environments.
Biopolymers 73:421-433.
Riemenschneider M, Klopp N, Xiang W, Wagenpfeil S, Vollmert C, Mueller U, Foerstl H, Illig T, Kretzschmar H, & Kurz A (2004)
Prion protein codon 129 polymorphismus and risk of Alzheimer disease.
Neurology 63 (2): 364-366
Schmidth OM, Niedmann P, Cepek L, Schröter A, Kretzschmar HA, & Poser S (2004)
CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias.
Dement Geriatr Cogn Disord 17: 204-206, 2004
Schober F, Kretzschmar HA, & Herms J (2004)
Bcl-2 expression inversely correlates with tumor cell differentiation in medulloblastoma
Neuropathol Appl Neurobiol 30: 513-521
Steinacker P, Mollenhauer B, Bibl M, Cepek L, Esselmann H, Brechlin P, Lewczuk P, Poser S, Kretzschmar HA, Wiltfang J, Trenkwalder C, & Otto M (2004)
Heart fatty acid binding protein as a potential diagnsostic marker for neurodegenerative diseases.
Neurosci Lett 370:36-39
Steinhoff B.J, Zerr I, Glatting M, Schulz-Schaeffer W, Poser S, & Kretzschmar H.A. (2004)
Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease.
Ann Neurol online Nov 2004
Xiang W, Windl O, Wünsch G, Dugas M, Kohlmann A, Dierkes N, Westner I.M, & Kretzschmar H.A. (2004)
Identification of Differentially Expressed Genes in Scrapie-Infected Mouse Brains by Using Global Gene Expression Technology.
J Virol 78 (20) 11051 -11060
Zerr I, Bodemer M, Kaboth U, Kretzschmar H, Oellerich M, & Armstrong  VW (2004)
Plasminogen activities and concentration in patients with sporadic Creutzfeldt-Jakob disease.
Neurosci Lett 371: 163-166
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2003

Bönnemann C.G, Thompson T.G, Van der Ven P.F.M, Goebel H, Warlo I, Vollmers B, Reimann J, Herms J, Gautel M, Takada F, Beggs A.H, Fürt D.O, Kunkel L.M, Hanefeld F, & Schröder R. (2003)
Filamin C accumulation is a strong but non-specific immunohistochemical marker of core formation in muscle.
J. Neurol. Sci. 206:71-8.
Erdlenbruch B, Schinkhof C, Kugler W, Heinemann D.E, Herms J, Eibl H, & Lakomek M. (2003)
Intracarotid administration of short-chain alkylglycerols for increased delivery of methotrexate to the rat brain.
Br. J. Pharmacol. 139:685-94.
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, & Van Leuven F. (2003)
Capacitative calcium entry is directly alleviated by mutant Presenilin-1, independent on the expression of amyloid precursor protein.
J. Biol. Chem. 278:2484-9
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, & van Leuven F. (2003)
Captative calcium entry is directly attenuated by mutant presinilin-1, independent of the expression of the amyloid precursor protein.
J Biol Chem; 278(4): 2484 - 2489.
Hopt A, Korte S, Fink H, Panne U, Niessner R, Jahn R, Kretzschmar HA, & Herms J (2003)
Methods for studying synaptosomal copper release.
J.Neurosci.Methods (2003) 128 (1-2), 159 -172
Korte S, Vasallo N, Kramer M.L, Kretzschmar H.A, & Herms J. (2003)
Prion protein affects L-type voltage gated calcium channels.
J. Neurochem. 87:1037-42.
Korte S, Vassallo N, Kramer M.L, Kretzschmar H.A, & Herms J (2003)
Modulation of L-type voltage-gated calcium channels by recombinant prion protein.
J.Neurochem.(2003) 87 (4), 1037 -1042
Kretzschmar HA (2003)
Diagnosis of prion diseases.
Clin Lab Med; 23(1): 109 - 128.
Kretzschmar HA, Sethi S, Földvári Z, Windl O, Querner V, Zerr I, & Poser S. (2003)
Iatrogenic Creutzfeldt-Jakob Disease with florid plaques.
Brain Pathol;13:245-249
Lewczuk P, Esselmann H, Meyer M, Wollscheid V, Neumann M, Otto M, Maler J.M, Ruther E, Kornhuber J, & Wiltfang J. (2003)
The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide.
Rapid Commun. Mass Spectrom. 17, 1291-1296.
Ratzka P, Dohlinger S, Cepek L, Steinacker P, Arlt S, Jacobi C, Schroter A, Wiltfang J, Prange H, Kretzschmar HA, Poser S, & Otto M (2003)
Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.
Neurosci Lett; 343(1): 29- 32
Riemenschneider M, Wagenpfeil S, Vanderstichele H, Otto M, Wiltfang J, Kretzschmar H, Vanmelchelen E, Forstl H, & Kurz A (2003)
Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias.
Mol. Psychiatry; 8(3): 343 - 347
Van der Knaap M, van Berkel C, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemse M.A.A, Plecko B, Proud C.G, & Pronk J.C. (2003)
The widening phenotype of vanishing white matter: early onset and involvement of organs other than the brain.
Am. J. Hum. Genet. 73:1199-207
Vassallo N, & Herms J (2003)
Cellular prion protein function in copper homeostasis and redox signalling at the synapse.
J.Neurochem. 86(3), 538 - 544
Wiltfang J, Esselmann H, Smirnov A, Bibl M, Cepek L, Steinacker P, Mollenhauer B, Buerger K, Hampel H, Paul S, Neumann N, Maler M, Zerr I, Kornhuber J, Kretzschmar HA, Poser S, & Otto M. (2003)
Beta-Amyloid Peptides in Cerebreospinal Fluid of Patients with Creutzfeldt-Jakob Disease.
Ann Neurol; 54: 263-267
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2002

Achim C, Auer R, Bergeron C, Cardozo A, Deprez M, de Vos R, Duyckaerts C, Egensperger R, Esiri M, Frosch MP, Giannini C, Goebel HH, Graeber MB, Graham DI, Gray F, Haltia M, Hashizuma Y, Ikeda K, Ironside JW, Kretzuberg GW, Lantos P, Lowee J, Ludwin S, Matsumoto Y, Olsson Y, Sasaki A, Schreithauer BW, Takahashi H, Tolnay M, Trojanowski JQ, Troost D, & Webster HD (2002)
Global democratic consensus on neuropathological disease criteria.
Lancet Neurology 1 (6): 340 (2002).
Kahle P.J, Haass Ch, Kretzschmar H.A, & Neumann M. (2002)
Structure / function of alpha-synuclein in health and disease: rational developement of animal models for Parkinson's and relates diseases.
J Neurochem. 82, 449 - 457
Kahle P.J, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin W.B, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar H.A, & Haass C. (2002)
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
EMBO reports 3, 6, 583-588.
Lorenz H, Windl O, & Kretzschmar H.A. (2002)
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.
J.Biol.Chem.277, 10, 8508-8516
Neumann M, Kahle P.J, Giasson B.I, Ozman l, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski J.Q, Kretzschmar H.A, & Haass Ch. (2002)
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
J.Clin.Invest. 110, 10, 1429 - 1439
Otto M, Wiltfang J, Cepek L, Neumann M, Mollenhauer B, Steinacker P, Ciesielczyk B, Schulz-Schaeffer W, & Kretzschmar H.A. (2002)
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease.
Neurology 58, 192-197.
Schmidt T, Lindenberg K.S, Krebs A, Schols L, Laccone F, Herms J, Rechsteiner M, Riess O, & Landwehrmeyer G.B. (2002)
Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions.
Ann. Neurol. 51:302-10.
Sethi S, Lipford G, Wagner H, & Kretzschmar H.A. (2002)
Postexposure prophylaxis against prion disease with a stimulator of innate immunity.
Lancet 360, 229-230.
Tschampa H.J, Herms J, Schulz-Schaeffer W, Maruschak B, Windl O, Jastrow U, Zerr I, Steinhoff B.J, Poser S, & Kretzschmar H.A (2002)
Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology
Brain 125:2558-66.
Wegner C, Römer A, Schmalzbauer R, Lorenz H, Windl O, & Kretzschmar H.A. (2002)
Mutant prion protein acquires resistance to protease in mouse neuroblastoma cells.
J.Gen.Virol.83, 5, 1237- 1245
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2001

Reusche E, Pilz P, Oberascher E, Lindner B, Egensperger R, Gloeckner K, Trinka E, & Iglseder K (2001)
Subacute fatal aluminium encephalopathy after reconstructive otoneurosurgery.
Hum Pathol 32:1136-1140 (2001).
Egensperger R, Scheithauer BW, Horvath E, Kovacs K, Giannini C, Young WFJ, Lloyd R, Atkinson J , & Nippoldt TB (2001)
Cushing's disease due to an ACTH-producing gonadotrophic pituitary adenoma.
Acta Neuropathol 102:398-403 (2001).
Augustin I, Korte S, Kretzschmar H.A, Südhoff T.C, Herms J, & Brose N. (2001)
Nonredundant and redundant roles of Munc13 isoforms in the regulation of neurotransmitter release.
J. Neurosci. 21:10-17.
Augustin I, Korte S, Rickmann M, Kretzschmar H.A, Sudhof T.C, Herms J.W, & Brose N. (2001)
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice.
J. Neurosci. 21, 10-17
Brück W, Herms J, Brockmann K, Schulz-Schaeffer W, & Hanefeld F. (2001)
Myelinopathia centralis diffusa (Vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development.
Ann. Neurol. 50:532-36.
Durig J, Giese A, Schmucker U, Kretzschmar H.A, & Duhrsen U. (2001)
Decreased prion protein expression in human peripheral blood leucocytes from patients with paroxysmal nocturnal haemoglobinuria.
Br. J. Haematol. 112 , 658-662.
Giese A, & Kretzschmar H.A. (2001)
Prion-induced neuronal damage--the mechanisms of neuronal destruction in the subacute spongiform encephalopathies.
Curr. Top. Microbiol. Immunol. 253, 203-217.
Herms J.W, Tings T, Dunker S, & Kretzschmar H.A. (2001)
Prion Protein Affects Ca(2+)-Activated K(+) Currents in Cerebellar Purkinje Cells.
Neurobiol. Dis. 8, 324-330.
Kahle P.J, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski J.Q, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar H.A, & Haass C. (2001)
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
Am. J. Pathol. 159, 2215-2225.
Kastenbauer S, Schulz-Schaeffer W.J, Tatsch K, Yousry T.A, Kretzschmar H.A, & Pfister H.W. (2001)
Crossed cerebellar diaschisis:clue to the mechanism of ataxic hemiparesis in Creutzfeldt-Jakob disease?
J.Neurol. 248, 1093-1095
Middel P, Reich K, Polzien F, Blaschke V, Hemmerlein B, Herms J, Korabiowska M, & Radzun H.J. (2001)
Interleukin-16 expression and phenotype of interleukin-16 producing cells in Crohn`s disease.
Gut 49:795-803.
Mueller W, Lass U, Herms J, Kuchelmeister K, Bergmann M, & von Deimling A. (2001)
Clonal analysis in glioblastoma with epithelial differentiation.
Brain Pathol. 11:39-43.
Neumann M, Schulz-Schaeffer W, Crowther R.A, Smith M.J, Spillantini M.G, Goedert M, & Kretzschmar H.A. (2001)
Pick's disease associated with the novel Tau gene mutation K369I.
Ann. Neurol. 50, 503-513.
Papos M, Pekrun A, Herms J.W, Behr T.M, Meller J, Rustenbeck H.H, Kretzschmar H.A, & Becker W. (2001)
Somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma: a case report.
Pediatr. Radiol.  31, 169-172.
Papòs M, Pekrun A, Herms J, Behr T.M, Meller J, Rustenbeck H.H, Kretzschmar H.A, & Becker W (2001)
Case report: somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma.
Pediatric Radiol. 31:169-72.
Rathke-Hartlieb S, Kahle P.J, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, & Schulz J.B. (2001)
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.
Neurochem. 77, 1181-1184.
Scheil S, Bruderlein S, Liehr T, Starke H, Herms J, Schulte M, & Moller P. (2001)
Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1.
Genes Chromosomes Cancer 32:203-11.
Scheil S, Brüderlein S, Eicher M, Herms J, Herold-Mende C, Steiner H.H, Barth T.F.E, & Möller P. (2001)
Low frequency of chromosomal imbalance in anaplastic ependymomas as detected by comparative genomic hybridization.
Brain Pathol. 11:133-43.
Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C, Gilis M, Geerts H, Moechars D, Kretzschmar H, Godaux E, Van Leuven F, & Herms J. (2001)
Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.
J. Biol. Chem. 276:11539-44.
Lamp E.C, & Schilling K. (2001)
Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex
Histochem Cell Biol 116(2):149-159
Steiner H, Revesz T, Neumann M, Romig H, Grim M.G, Pesold B, Kretzschmar H.A, Hardy J, Holton J.L., Baumeister R, Houlden H, & Haass C. (2001)
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
J. Biol. Chem. 276, 7233-7239.
Tschampa H.J, Neumann M, Zerr I, Henkel K, Schroter A, Schulz-Schaeffer W.J, Steinhoff B.J, Kretzschmar H.A, & Poser S. (2001)
Patients with Alzheimer's disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob disease.
J. Neurol. Neurosurg. Psychiatry 71, 33-39.
Tschampa H.J, Schulz-Schaeffer W, Wiltfang J, Poser S, Otto M, Neumann M, & Kretzschmar H.A. (2001)
Decreased CSF amyloid beta42 and normal tau levels in dementia with Lewy bodies.
Neurology 56, 576
Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Ruther E, Kornhuber J, Annaert W, De Strooper B, & Saftig P. (2001)
Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.
J. Biol. Chem. 276, 42645-42657.
nach oben

2000

Widjaja A, Mix H, Gölkel C, Flemming F, Egensperger R, Holstein A, Rademarker J, Becker H, Hundt M, Wagner S, & Manns MP (2000)
Uncommon metastasis of a glioblastoma multiforme in liver and spleen.
Digestion 61:219-222 (2000).
von Eitzen U, Kösel S, Grasbon-Frodl EM, Egensperger R, & Graeber MB (2000)
Sequence analysis of the MTCYB gene in Parkinson disease.
Neurogenetics 3:47-48 (2000).
Müller-Vahl KR, Kolbe H, Egensperger R, & Dengler R (2000)
AAEM news and comments.
Muscle Nerve 23:651-654 (2000).
Müller-Vahl KR, Kolbe H, Egensperger R, & Dengler R (2000)
Mitochondriopathy, blepharospasm, and treatment with botulinum toxin.
Muscle Nerve 23:647-648 (2000).
Grasbon-Frodl EM, Egensperger R, Kösel S, Krüger R, Riess O, Mehraein P, & Graeber MB (2000)
The Alpha1-antichymotrypsin A-allele in German Parkinson disease patients.
J Neural Transmiss 106:729-736 (2000).
Bieschke J, Giese A, Schulz-Schaeffer W, Zerr I, Poser S, Eigen M, & Kretzschmar H. (2000)
Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets.
Proc. Natl. Acad. Sci. U. S. A 97, 5468-5473.
Bleich S, Kropp S, Degner D, Zerr I, Pilz J, Gleiter C.H, Otto M, Ruther E, Kretzschmar H.A, Wiltfang J, Kornhuber J, & Poser S. (2000)
Creutzfeldt-Jakob disease and oxidative stress.
Acta Neurol. Scand. 101 , 332-334.
Durig J, Giese A, Schulz-Schaeffer W, Rosenthal C, Schmucker U, Bieschke J, Duhrsen U, & Kretzschmar H.A. (2000)
Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.
Br J Haematol 108, 488-495.
Giese A, Bieschke J, Eigen M, & Kretzschmar H.A. (2000)
Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases.
Arch. Virol. Suppl 161-171.
Herms J, Neidt I, Luscher B, Sommer A, Schurmann P, Schroder T, Bergmann M, Wilken B, Probst-Cousin S, Hernaiz-Driever P, Behnke J, Hanefeld F, Pietsch T, & Kretzschmar H.A. (2000)
C-MYC expression in medulloblastoma and its prognostic value.
Int. J. Cancer 89, 395-402.
Herms J.W, Korte S, Gall S, Schneider I, Dunker S, & Kretzschmar H.A. (2000)
Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice.
J. Neurochem. 75, 1487-1492.
Kahle P.J, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der P.H, Probst A, Kremmer E, Kretzschmar H.A., & Haass C. (2000)
Subcellular localization of wild-type and Parkinson's disease- associated mutant alpha -synuclein in human and transgenic mouse brain.
J. Neurosci. 20, 6365-6373.
Kahle P.J, Neumann M, Ozmen L, & Haass C. (2000)
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.
Ann. N. Y. Acad. Sci. 920, 33-41.
Neumann M, Adler S, Schluter O, Kremmer E, Benecke R, & Kretzschmar H.A. (2000)
Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies.
Acta Neuropathol. (Berl) 100, 568-574.
Otto M, Esselmann H, Schulz-Shaeffer W, Neumann M, Schroter A, Ratzka P, Cepek L, Zerr I, Steinacker P, Windl O, Kornhuber J, Kretzschmar H.A, Poser S, & Wiltfang J. (2000)
Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neurology 54, 1099-1102.
Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, Kopp N, Schulz-Schaeffer W.J, Kretzschmar H.A, Head M.W, Ironside J.W, Gambetti P, & Chen S.G (2000)
Genetic influence on the structural variations of the abnormal prion protein.
Proc. Natl. Acad. Sci. U. S. A 97, 10168-10172.
Poser S, Zerr I, Schroeter A, Otto M, Giese A, Steinhoff B.J, & Kretzschmar H.A. (2000)
Clinical and differential diagnosis of Creutzfeldt-Jakob disease.
Arch. Virol. Suppl 153-159.
Post K, Brown D.R, Groschup M, Kretzschmar H.A, & Riesner D. (2000)
Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro
Arch. Virol. Suppl 265-273.
Qin K, Yang D.S, Yang Y, Chishti M.A, Meng L.J, Kretzschmar H.A, Yip C.M, Fraser P.E, & Westaway D. (2000)
Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation.
J Biol Chem 275, 19121-19131.
Scaravilli F, Cordery R.J, Kretzschmar H, Gambetti P, Brink B, Fritz V, Temlett J, Kaplan C, Fish D, An S.F, Schulz-Schaeffer W.J, & Rossor M.N. (2000)
Sporadic fatal insomnia: a case study.
Ann. Neurol. 48, 665-668.
Schulz-Schaeffer W.J, Fatzer R, Vandevelde M, & Kretzschmar H.A. (2000)
Detection of PrP(Sc) in subclinical BSE with the paraffin-embedded tissue (PET) blot.
Arch. Virol. Suppl 173-180.
Schulz-Schaeffer W.J, Tschöke S, Kranefuss N, Hause-Reitner D, Giese A, Groschup M.H, & Kretzschmar H.A. (2000)
The Paraffin-Embedded Tissue Blot Detects PrP(Sc) Early in the Incubation Time in Prion Diseases.
Am J Pathol 156, 51-56.
Zerr I, Schulz-Schaeffer W.J, Giese A, Bodemer M, Schroter A, Henkel K, Tschampa H.J, Windl O, Pfahlberg A, Steinhoff B.J, Gefeller O, Kretzschmar H.A, & Poser S. (2000)
Current clinical diagnosis in Creutzfeldt-Jakob disease: identification of uncommon variants.
Ann. Neurol. 48, 323-329.
nach oben

1999

Schramm M, Falkai P, Pietsch T, Neidt I, Egensperger R, & Bayer T (1999)
Neural expression profile of Elav-like genes in human brain.
Clin Neuropathol 18: 17-22 (1999).
Bayer TA, Jäkälä P, Hartmann T, Egensperger R, Buslei R, Falkai P, & Beyreuther K (1999)
Neural expression profile of Alpha-synuclein in developing human cortex.
Neuroreport 10:2799-2803 (1999).
Tolnay M, Calhoun M, Pham HC, Egensperger R, & Probst A (1999)
Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease.
Neuropathol Appl Neurobiol 25:295-305 (1999).
Egensperger R, Weggen S, Ida N, Multhaup G, Schnabel R, Beyreuther K, & Bayer TA (1999)
Reverse relationship between APP and ßA4 plaques in Down syndrome versus sporadic/familial Alzheimer's disease.
Acta Neuropathol 97:113-118 (1999).
Almer G, Hainfellner J.A, Brucke T, Jellinger K, Kleinert R, Bayer G, Windl O, Kretzschmar H.A, Hill A, Sidle K, Collinge J, & Budka H. (1999)
Fatal familial insomnia: a new Austrian family.
Brain 122 ( Pt 1), 5-16.
Alperovitch A, Zerr I, Pocchiari M, Mitrova E, Cuesta J.D, Hegyi I, Collins S, Kretzschmar H, vanDujn C, & Will R.G. (1999)
Codon 129 prion protein genotype and sporadic Creutzfeldt-Jakob disease.
Lancet 353, 1673-1674.
Bürkle A, Kretzschmar H.A, & Brown D.R. (1999)
Poly(ADP-ribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein.
Histochemical Journal 11, 711-716.
Harder A, Jendroska K, Kreutz F, Wirth T, Schafranka C, Karnatz N, Theallier-Janko A, Dreier J, Lohan K, Emmerich D, Cervos-Navarro J, Windl O, Kretzschmar H.A, Nurnberg P, & Witkowski R. (1999)
Novel twelve-generation kindred of fatal familial insomnia from Germany representing the entire spectrum of disease expression.
Am. J. Med. Genet. 87, 311-316.
Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, Schurmann P, Windl O, Brose N, & Kretzschmar H. (1999)
Evidence of presynaptic location and function of the prion protein.
J. Neurosci.  19, 8866-8875.
Kropp S, Zerr I, Schulz-Schaeffer W.J, Riedemann C, Bodemer M, Laske C, Kretzschmar H.A, & Poser S. (1999)
Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease.
Neurosci. Lett. 261, 124-126.
Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Zerr I, Budka H, Kopp N, Piccardo P, Poser S, Rojiani A, Streichemberger N, Julien J, Vital C, Ghetti B, Gambetti P, & Kretzschmar H. (1999)
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.
Ann. Neurol. 46, 224-233
Poser S, Mollenhauer B, Kraubeta A, Zerr I, Steinhoff B.J, Schroeter A, Finkenstaedt M, Schulz-Schaeffer W.J, Kretzschmar H.A, & Felgenhauer K. (1999)
How to improve the clinical diagnosis of Creutzfeldt-Jakob disease.
Brain 122 ( Pt 12), 2345-2351.
Samman I, Schulz-Schaeffer W, Wöhrle J.C, Sommer A, Kretzschmar H.A, & Hennerici M (1999)
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type.
J. Neurol. Neurosurg. Psychiatry 67, 678-681.
Skworc K.H, Windl O, Schulz-Schaeffer W.J, Giese A, Bergk J, Nagele A, Vieregge P, Zerr I, Poser S, & Kretzschmar H.A. (1999)
Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene [In Process Citation].
Ann Neurol 46, 693-700.
Wiltfang J, Otto M, Baxter H.C, Bodemer M, Steinacker P, Bahn E, Zerr I, Kornhuber J, Kretzschmar H.A, & Poser S. (1999)
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Cretzfeldt-Jakob disease.
J. Neurochem. 73, 2485-2490.
Windl O, Giese A, Schulz-Schaeffer W, Skworc K, Arendt S, Oberdieck C, Bodemer M, Zerr I, Poser S, & Kretzschmar H.A. (1999)
Molecular genetics of human prion diseases in Germany.
Hum. Genetics 105, 244-252.
Windl O, Lorenz H, Behrens C, Römer A, & Kretzschmar H.A (1999)
Construction and characterization of murine neuroblastoma cell clones allowing inducible and high expression of the prion protein.
J. Gen. Virol. 80, 15.
nach oben

1998

von Eitzen U, Egensperger R, Kösel S, Grasbon-Frodl EM, Imai Y, Bise K, Kohsaka S, Mehraein P, & Graeber MB (1998)
Microglia and the development of spongiform change in Creutzfeldt-Jakob disease.
J Neuropathol Exp Neurol 57:246-256 (1998).
Egensperger R, Herrmann H, Kösel S, & Graeber MB (1998)
Association between ACT polymorphism and Alzheimer's disease.
Neurology 50:575-576 (1998).
Tolnay M, Probst A, Monsch AU, Staehlin HB, & Egensperger R (1998)
Apolipoprotein E allele frequencies in argyrophilic grain disease.
Acta Neuropathol 96:225-227 (1998).
Egensperger R, Kösel S, von Eitzen U, Mehraein P, & Graeber MB (1998)
Microglial activation in Alzheimer disease: Association with APOE genotype
Brain Pathol 8:439-447 (1998).
von zur Mühlen F, Klass C, Kreutzer H, Mall G, Giese A, & Reimers CD (1998)
Cardiac involvement in proximal myotonic myopathy.
Heart (1998) 6, 619-621.
Warzok RW, Kessler C, Apel G, Schwarz A, Egensperger R, Schreiber D, Herbst EW, Wolf E, Walther R, & Walker LC (1998)
Apolipoprotein E4 promotes incipient Alzheimer pathology in the elderly.
Alzheimer Dis Assoc Disord 12:33-39 (1998).
Kösel S, Grasbon-Frodl EM, Mautsch U, Egensperger R, von Eitzen U, Frishman D, Hofmann S, Gerbitz KD, Mehraein P, & Graeber MB (1998)
Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease.
Neurogenetics 1:197-204 (1998).
Tran CT, Wolz P, Egensperger R, Kösel S, Imai Y, Bise K, Kohsaka S, Mehraein P, & Graeber MB (1998)
Differential expression of MHC class II molecules by microglia and neoplastic astroglia: relevance for the escape of astrocytoma cells from immune surveillance.
Neuropathol Appl Neurobiol 24:293-301 (1998).
Brown D.R, Besinger A, Herms J.W, & Kretzschmar H.A. (1998)
Microglial expression of the prion protein.
Neuroreport 9, 1425-1429.
Brown D.R, & Kretzschmar H.A. (1998)
The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes.
J. Neurocytol. 27, 109-118.
Brown D.R, Pitschke M, Riesner D, & Kretzschmar H.A. (1998)
Cellular effects of a neurotoxic prion protein peptide are related to its b-sheet content.
Neuroscience Research Communications 23, 119.
Brown D.R, Schmidt B, & Kretzschmar H.A. (1998)
A prion protein fragmant primes type 1 astrocytes to proliferation signals from microglia.
Neurobiol. Disease 4, 410-422.
Brown D.R, Schmidt B, & Kretzschmar H.A. (1998)
Prion protein fragment interacts with PrP-deficient cells.
Journal of Neuroscience Research 52, 260-267.
Brown D.R, Schmidt B, & Kretzschmar H.A. (1998)
Effects of copper on survival of prion protein knockout neurons and glia.
J. Neurochem. 70, 1686-1693
Giese A, Brown D.R, Groschup M, Feldmann C, Haist I, & Kretzschmar H.A. (1998)
Role of microglia in neuronal cell death in prion disease.
Brain Pathol. 8, 449-457.
Herms J.W, Gall S, Tings T, Dunker S, & Kretzschmar H.A. (1998)
Pathophysiological consequences of the loss of copper binding ability of pf Prnp0/0 mice at the neuronal membrane.
Clin. Neuropathol. 17, 254.
Herms J. W, Tings T, Dunker S, & Kretzschmar H. A. (1998)
Prion protein modulates calcium activates potassium currents in cerebellar Purkinje cells.
Soc.Neurosci.Abst. 24. 1998.
Kretzschmar H, Giese A, Zerr I, Windl O, Schulz-Schaeffer W, Skworc K, & Poser S. (1998)
The German FFI cases.
Brain Pathol. 8, 559-561
Otto M, Wiltfang J, Schütz E, Zerr I, Otto A, Pfahlberg A, Gefeller O, Uhr M., Giese A, Weber T, Kretzschmar H.A, & Poser S. (1998)
Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study
Brit. Med. J. 316, 577-582.
Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar H.A, & Weber T. (1998)
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Ann. Neurol. 43, 32-38.
Zerr I, Giese A, Windl O, Kropp S, Schulz-Schaeffer W, Riedemann C, Skworc K, Bodemer M, Kretzschmar H.A, & Poser S. (1998)
Phenotypic variability in fatal familial insomnia (D178N-129M) genotype.
Neurology 51, 1398-1405.
nach oben

1997

Maslim J, Valter K, Egensperger R, Holländer H, & Stone J (1997)
Tissue oxygen during a critical developmental period controls the death and survival of photoreceptors.
Invest Ophthalmol Vis Sci 38:1667-1677 (1997).
Kösel S, Egensperger R, Schnopp NM, & Graebner MB (1997)
The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.
Movement Disord 12:639-645 (1997).
Kösel S, Egensperger R, Bise K, Arbogast S, Mehraein P, & Graeber MB (1997)
Long-lasting perivascular accumulation of major histocompatibility complex class II-positive lipophages in the spinal cord of stroke patients: possible relevance for the immune privilege of the brain.
Acta Neuropathol 94:532-538 (1997).
Herms J, Behnke J, Bergmann M, Christen HJ, Kolb R, Wilkening M, Markakis E, Hanefeld F, & Kretzschmar HA (1997)
Potential Prognostic Value of C-erbB-2 Expression in Medulloblastomas in Very Young Children
J. of Pediatric Hem/Onc. 1997, 19(6):510-515
Bancher C, Egensperger R, Kösel S, Jellinger K, & Graeber MB (1997)
Low prevalence of apolipoprotein E 4 allele in the neurofibrillary tangle predominant form of senile dementia.
Acta Neuropathol 94:403-409 (1997).
Egensperger R, Kösel S, Schnopp NM, Mehraein P, & Graebner MB (1997)
Association of the mitochondrial tRNAA4336G mutation with Alzheimer's and Parkinson's diseases.
Neuropathol Appl Neurobiol 23:315-321 (1997).
Kösel S, Egensperger R, von Eitzen U, Mehraein P, & Graebner MB (1997)
On the question of apoptosis in the parkinsonian substantia nigra.
Acta Neuropathol 93:105-108 (1997).
Graebner MB, Kösel S, Egensperger R, Banati RB, Müller U, Bise K, Hoff P, Möller HJ, Fujisawa K, Mehraein P, Schnopp NM, & Mehraein P (1997)
Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis.
Neurogenetics 1:73-80 (1997)
Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, & Groschup M (1997)
Cell death in prion disease.
J Neural Transm Suppl. 1997;50:191-210.
Behring B, Bruck W, Goebel H.H, Behnke J, Pekrun A, Christen H.J, & Kretzschmar H.A (1997)
Immunohistochemistry of primary central nervous system malignant rhabdoid tumors: report of five cases and review of the literature.
Acta Neuropathol. (Berl) 91, 578-586.
Bergmann M, Kuchelmeister K, Schmid K.W, Kretzschmar H.A, & Schröder R. (1997)
Different variants of frontotemporal dementia: a neuropathological and immunohistochemical study.
Acta Neuropath 92, 170-179.
Brown D.R, Herms J, Schmidt B, & Kretzschmar H.A. (1997)
PrP and b-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells.
Eur. J. Neurosci. 9, 1162-1169.
Brown D.R, Qin K, Herms J.W, Madlung A, Manson J, Strome R, Fraser P, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A. Westaway D. and, & Kretzschmar H. (1997)
The cellular prion protein binds copper in vivo.
Nature 390, 684-687.
Brown D.R, Schmidt B, & Kretzschmar H.A. (1997)
Effects of oxidative stress on prion protein expression in PC12 cells.
Int. J. Dev. Neurosci. 15, 961-972.
Brown D.R, Schulz-Schaeffer W.J, Schmidt B, & Kretzschmar H.A. (1997)
Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.
Exp. Neurol. 146, 104-112.
Giese, A. Schulz-Schaeffer W, Windl O, Zerr I, Poser S, Parchi P, Gambetti P, & Kretzschmar H. A (1997)
A novel classification scheme of sporadic Creutzfeldt-Jakob disease based on molecular analysis.
Clinical Neuropathology 16, 259-259. 1997.
Herms J, Madlung A, Brown D.R, & Kretzschmar H.A. (1997)
Increase of intracellular free Ca2+ in microglia activated by prion protein fragment.
Glia 21, 253-257.
Korth C, Stierli B, Streit P, Moser M, Schaller O, Fischer R, Schulz-Schaeffer W, Kretzschmar H, Raeber A, Braun U, Ehrensperger F, Hornemann S, Glockshuber R, Riek R, Billeter M, Wüthrich K, & Oesch B. (1997)
Prion (PrPSc)-specific epitope defined by a monoclonal antibody.
Nature 390, 74-77.
Otto M, Stein H, Szudra A, Zerr I, Bodemer M, Gefeller O, Poser S, Kretzschmar H.A, Mäder M, & Weber T. (1997)
S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
J. Neurol. 244, 566-570.
Otto M, Wiltfang J, Tumni H, Zerr I, Lantsch M, Kornhuber J, Weber T, Kretzschmar H.A, & Poser S. (1997)
Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neurosci. Lett. 225, 210-213.
Parchi P, Capellari S, Chen S.G, Petersen R.B, Gambetti P, Kopp N, Brown P, Kitamoto T, Tateishi J, Giese A, & Kretzschmar H. (1997)
Typing prion isoforms.
Nature 386, 232-233.
Schallock K, Schulz-Schaeffer W.J, Giese A, & Kretzschmar H.A. (1997)
Postmortem delay and temperature conditions affect the in situ end- labeling (ISEL) assay in brain tissue of mice.
Clin. Neuropathol. 16, 133-136.
Schulz-Schaeffer W, Giese A, & Kretzschmar H. A. (1997)
PET-Blot - a new method of sensitive prion protein detection.
Clinical Neuropathology 16, 288-288. 1997.
Schwaninger M, Winter R, Hacke W, von Kummer R, Sommer C, Kiessling M, Schulz-Schaeffer W, & Kretzschmar H.A. (1997)
Magnetic resonance imaging in Creutzfeldt-Jakob disease: Evidence of focal involvement of the cortex.
J. Neurol. Neurosurg. Psychiatry 63, 408-409.
Weber T, Trebst C, Frye S, Cinque P, Vago L, Sindic C.J, Schulz-Schaeffer W.J, Kretzschmar H.A, Enzensberger W, Hunsmann G, & Luke W. (1997)
Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy.
J. Infect. Dis. 176, 250-254.
Weiss S, Proske D, Neumann M, Groschup M.H, Kretzschmar H.A, Famulok M, & Winnacker E.-L. (1997)
RNA aptamers specifically interact with prion protein (PrP)
J. Virol. 71, 8790-8797.
nach oben

1996

Kurz A, Egensperger R, Haupt M, Lautenschlager N, Romero B, Graebner MB, & Müller U (1996)
Apolipoprotein E 4 allele, cognitive decline, and deterioration of everyday performance in Alzheimer's disease.
Neurology 47:440-443 (1996)
Schopp NM, Kösel S, Egensperger R, & Graebner MB (1996)
Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain.
Clin Neuropathol 15:348-352 (1996).
Egensperger R, Bancher C, Kösel S, Jellinger K, Mehraein P, & Graebner MB (1996)
The apolipoprotein E 4 allele in Parkinson's disease with Alzheimer lesions.
Biochem Biophys Res Comm 224:484-486 (1996).
Egensperger R, Maslim J, Bisti S, Holländer H, & Stone J (1996)
Fate of DNA from retinal cells dying during development: uptake by microglia and macroglia (Müller cells).
Brain Res Dev Brain Res 97:1-8 (1996)
Kösel S, Lücking CB, Egensperger R, Mehraein P, & Graebner MB (1996)
Mitochondrial NADH dehydrogenase and CYP2D6 genotypes in Lewy body Parkinsonism.
J Neurosci Res 44:174-183 (1996)
Brown D. R, & Kretzschmar H. A. (1996)
Role of prion protein in resistance to oxidative stress and regulation of superoxide dismustase
Society for Neuroscience 22, 708.
Brown D.R, Schmidt B, & Kretzschmar H.A. (1996)
Role of microglia and host prion protein in neurotoxicity of prion protein fragment.
Nature 380, 345-347
Brown D.R, Schmidt B, & Kretzschmar H.A. (1996)
A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture.
Glia 18, 59-67.
Giese A, Feldmann C, Brown D.R, Groschup M.H, & Kretzschmar H.A (1996)
Sequence of neuropathological changes and apoptosis in prion disease.
Clin. Neuropathol. 15, 271.
Herms J. W, Madlung A, Brown D. R, & Kretzschmar H. A. (1996)
Prion protein fragment induces increase of intracellular free Ca2+ in cultured rat microglia.
Soc.Neurosci.Abst. 22, 285. 1996.
Kohlhase J, Schuh R, Dowe G, Kuhnlein R.P, Jackle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar H.A, Kohler A, Muller U, Raab-Vetter M, Burkhardt E, Engel W, & Stick R. (1996)
Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt.
Genomics 38, 291-298
Kretzschmar H.A, Giese A, Brown D.R, Herms J, Schmidt B, & Groschup M. (1996)
Transmissible Subacute Spongiform Encephalopathies: Prion Disease
Prion Disease 97-106.
Giese A, Schulz-Schaeffer WJ, Windl O, & Kretzschmar H.A (1996)
Rinderwahn und Creutzfeldt-Jakob-Krankheit: Neue Erkenntnisse der Prionforschung.
Deutsches Ärzteblatt 93(14): 902-904.
Schulz-Schaeffer W.J, Giese A, Windl O, & Kretzschmar H.A. (1996)
Polymorphism at codon 129 of the prion protein gene determines cerebellar pathology in Creutzfeldt-Jakob disease.
Clin. Neuropathol. 15, 353-357.
Steinhoff B.J, Räcker S, Herrendorf G, Poser S, Grosche S, Zerr I, Kretzschmar H.A, & Weber T. (1996)
Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt-Jakob disease.
Arch. Neurol. 53, 162-166.
Tateishi J, Kitamoto T, Kretzschmar H.A, & Mehraein P. (1996)
Immunhistological evaluation of Creutzfeldt-Jakob disease with reference to the type PrPres deposition.
Clin. Neuropathol. 15, 358-360.
Weis J, Kretzschmar H.A, Windl O, Podoll K, & Schwarz M. (1996)
Fatal spongiform encephalopathy in a patient who had handled animal feed.
Lancet 348, 1240.
Windl O, Dempster M, Estibeiro J.P, Lathe R, De Silva R, Esmonde T, Will R, Springbett A, Campbell T.A, Sidle K.C.L, Palmer M.S, & Collinge J. (1996)
Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variations in the PRNP gene.
Hum. Genetics 98, 259-264.
Zerr I, Bodemer M, Otto M, Poser S, Windl O, Kretzschmar H.A, Gefeller O, & Weber T. (1996)
Diagnosis of Creutzfeldt-Jakob-disease by two-dimensional gel electrophoresis of cerebrospinal fluid.
Lancet 348, 846-849.
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1995

Kurz A, Egensperger R, Lautenschlager N, Haupt M, Altland K, Graebner MB, & Müller U (1995)
Das Apolipoprotein E Gen und der Phänotyp der Alzheimer Krankheit.
Z Gerontol Geriat 28:195 199 (1995).
Egensperger R, Kösel S, Schnabel R, Mehraein P, & Graebner MB (1995)
Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14 linked early onset Alzheimer's disease.
Acta Neuropathol 90:257 265 (1995).
Bogumil T, Jacobsen T, Windl O, Giese A, Beuche W, Zerr I, Räcker S, Grosche S, Szudra A, Poser S, Weber T, & Kretzschmar H.A. (1995)
Cerebellar changes in sporadic Creutzfeldt-Jakob disease: A synopsis of clinical, histological, immunohistochemical, and genetic data
E. J. Pathol. 1.3.
Brown D.R, & Kretzschmar H.A. (1995)
Topographical reinnervation of the toad glutaeus muscle by axons of only one spinal nerve.
Neuroreport 6, 989-993.
Brück W, Porada P, Poser S, Rieckmann P, Hanefeld F, Kretzschmar H. A, & Lassmann H. (1995)
Monocyte/macrophage differentiation in early multiple sclerosis lesions.
Annals of Neurology . 1995.
Brück W, Sommermeier N, Bergmann M, Zettl U, Goebel H. A, Kretzschmar H. A, & Lassmann H. (1995)
Macrophages in multiple sclerosis.
Immunobiology . 1995.
Brück Y, Brück W, Kretzschmar H. A, & Lassmann H. (1995)
Evidence for neuronal apoptosis in pontosubicular neuron necrosis.
Neuropathology and Applied Neurobiology . 1995.
Frenzel K.H, Muller N, Heidmann D, Hampel H, Kretzschmar H.A, Penning R, & Ackenheil M. (1995)
Expression of T cell receptor gamma delta antigens in human brain tissue.
Neuroimmunomodulation. 2, 115-120.
Giese A, Groschup M.H, Hess B, & Kretzschmar H.A. (1995)
Neuronal cell death in scrapie-infected mice is due to apoptosis.
Brain Pathol. 5, 213-221.
Giese A, Schulz-Schaeffer W.J, & Kretzschmar H.A. (1995)
Vorsichtsmassnahmen bei der Durchführung von Autopsien bei Verdacht auf Creutzfeldt-Jakob-Erkrankung.
Verh. Dtsch. Ges. Path. 79, 631.
Herms J.W, Kretzschmar H.A, Titz S, & Keller B.U. (1995)
Patch-clamp analysis of synaptic transmission to cerebellar Purkinje cells of prion protein knockout mice.
Eur. J. Neurosci. 7, 2508-2512.
Krasemann S, Zerr I, Weber T, Poser S, Kretzschmar H.A, Hunsmann G, & Bodemer W. (1995)
Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene.
Mol. Brain Res. 34, 173-176.
Kretzschmar H.A, Bogumil T, Giese A, & Windl O. (1995)
Pathologie und Genetik der humanen spongiformen Enzephalopathien in Deutschland.
Verh. Dtsch. Ges. Path. 79, 567.
Kretzschmar H.A, Neumann M, & Stavrou D. (1995)
Codon 178 mutation of the human prion protein gene in a German family (Backer family): sequencing data from 72 year-old celloidin-embedded brain tissue.
Acta Neuropathol. (Berl. ) 89, 96-98.
Obermaier G, Kretzschmar H.A, Hafner A, Heubeck D, & Dahme E. (1995)
Spongiform central nervous system myelinopathy in African dwarf goats.
J. Comp. Path. 113, 357-372.
Windl O, Dempster M, Estibeiro P, & Lathe R. (1995)
A candidate marsupial PrP gene reveals two domains conserved in mammalian PrP proteins.
Gene 159, 181-186.
Zerr I, Bodemer M, Räcker S, Grosche S, Poser S, Kretzschmar H.A, & Weber T. (1995)
Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease.
Lancet 345, 1609-1610.
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1994

Kösel S, Egensperger R, Mehraein P, & Graebner MB (1994)
No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease.
Biochem Biophys Res Comm 203:745 749 (1994).
Brown D.R, Herms J, & Kretzschmar H.A (1994)
Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment.
Neuroreport 5, 2057-2060.
Herms J, Zurmohle U, Schlingensiepen R, Brysch W, & Schlingensiepen K.H. (1994)
Developmental expression of the transcription factor zif268 in rat brain.
Neurosci. Lett. 165, 171-174.
Kaaden O.R, Truyen U, Groschup M.H, Uysal A, Kaiser E, Kretzschmar H.A, Bogumil T, Pohlenz J, Diringer H, Steinhagen P, & Dahme E. (1994)
Bovine spongiform encephalopathy in Germany.
Zentralblatt für Veterinärmedizin 41, 294-304.
Schumacher U, Adam E, Kretzschmar H, & Pfuller U. (1994)
Binding patterns of mistletoe lectins I, II and III to microglia and Alzheimer plaque glycoproteins in human brains
Acta Histochem. 96, 399-403
Schumacher U, Kretzschmar H, & Pfuller U. (1994)
Staining of cerebral amyloid plaque glycoproteins in patients with Alzheimer's disease with the microglia-specific lectin from mistletoe.
Acta Neuropathol. (Berl) 87, 422-424.
Treiber-Held S, Budjarjo-Welim H, Reimann D, Richter J, Kretzschmar H.A, & Hanefeld F. (1994)
Giant axonal neuropathy: a generalized disorder of intermediate filaments with longitudinal grooves in the hair.
Neuropediatrics 25, 89-93.
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1993

Herms J, Zurmohle U, Schlingensiepen K.H, & Brysch W. (1993)
Transient expression of PKC gamma mRNA in cerebellar granule cells during rat brain development.
Neuroreport  4, 899-902.
Herms J, Zurmohle U, Brysch W, & Schlingensiepen K.H. (1993)
Ca2+/calmodulin protein kinase and protein kinase C expression during development of rat hippocampus.
Dev. Neurosci. 15, 410-416.
Weber T, Tumani H, Holdorff B, Collinge J, Palmer M., Kretzschmar H.A, & Felgenhauer K. (1993)
Transmission of Creutzfeld-Jakob disease by handling of dura mater
Lancet 341, 123-124.
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1992

Gabriel J.M, Oesch B, Kretzschmar H.A, Scott M, & Prusiner S.B. (1992)
Molecular cloning of a candidate chicken prion protein.
Proc. Natl. Acad. Sci. USA 89, 9097-9101.
Kretzschmar H.A, Kufer P, Riethmüller G, DeArmond S.J, Prusiner S.B, & Schiffer D. (1992)
Prion protein mutation at codon 102 in an Italian family with Gerstmann-Sträussler-Scheinker syndrome.
Neurology 42, 809-810.
Kretzschmar H.A, Neumann M, Riethmüller G, & Prusiner S.B. (1992)
Molecular cloning of a mink prion protein gene.
J. Gen. Virol. 73, 2757-2761.
Schumacher U, Kretzschmar H, Brooks S, & Leathem A. (1992)
Helix pomatia lectin binding pattern of brain metastases originating from breast cancers.
Pathol. Res. Pract. 188, 284-286.
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1991

Jendroska K, Heinzel F.P, Torchia M, Stowring L, Kretzschmar H.A, Kon A, Stern A, Prusiner S.B, & DeArmond S.J. (1991)
Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity.
Neurology 41, 1482-1490.
Kretzschmar H.A, Honold G, Seitelberger F, Feucht M, Wessely P, Mehraein P, & Budka H. (1991)
Prion protein mutation in family first reported by Gerstmann, Sträussler, and Scheinker.
Lancet  337, 1160-1160.
Kretzschmar H.A, Kitamoto T, Doerr-Schott J, Mehraein P, & Tateishi J. (1991)
Diffuse deposition of immunohistochemically labeled prion protein in the granular layer of the cerebellum in a patient with Creutzfeldt-Jakob disease.
Acta Neuropathol. (Berl. ) 82, 536-540.
Schumacher U, Kretzschmar H.A, & Tateishi J. (1991)
Carbohydrate histochemistry of amyloid plaques in Gerstmann-Sträussler syndrome.
Eur. J. Basic. Appl. Histochem. 35, 331-340.
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1990

Bertalanffy H, Kretzschmar H, Gilsbach J.M, Ott D, & Mohadjer M. (1990)
Large colloid cyst in lateral ventricle simulating brain tumour. Case report.
Acta Neurochir. (Wien. ) 104, 151-155.
Kretzschmar H.A, Wagner H, Hubner G, Danek A, Witt T.N, & Mehraein P. (1990)
Aneurysms and vacuolar degeneration of cerebral arteries in late-onset acid maltase deficiency.
J. Neurol. Sci. 98, 169-183.
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1989

Holländer H, Egensperger R, & Dirlich G (1989)
Size distribution of rhodamine labelled microspheres retrogradely transported in cultured neurons.
J Neurosci Methods 29:1 4 (1989)
Stavrou D, Bise K, Groeneveld J, Stocker U, Kretzschmar H.A, Keiditsch E, & Mehraein P. (1989)
Antigenic heterogeneity of human brain tumors defined by monoclonal antibodies.
Anticancer Res. 9, 1489-1496.
nach oben

1988

Egensperger R, & Holländer H (1988)
Electron microscopic visualization of fluorescent microspheres used as a neuronal tracer.
J Neurosci Methods 23:81 186 (1988).
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1987

Kretzschmar H.A, Berg B.O, & Davis R.L. (1987)
Giant axonal neuropathy. A neuropathological study 15.
Acta Neuropathol. (Berl) 73, 138-144.
Kretzschmar H.A, DeArmond S.J, Koch T.K, Patel M.S, Newth C.J, Schmidt K.A, & Packman S. (1987)
Pyruvate dehydrogenase complex deficiency as a cause of subacute necrotizing encephalopathy (Leigh disease).
Pediatrics 79, 370-373.
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1986

Kretzschmar H.A, Prusiner S.B, Stowring L.E, & DeArmond S.J (1986)
Scrapie prion proteins are synthesized in neurons
Am. J. Pathol. 122, 1-5.
Kretzschmar H.A, Stowring L.E, Westaway D, Stubblebine W.H, Prusiner S.B, & DeArmond S.J. (1986)
Molecular cloning of a human prion protein cDNA
DNA 5, 315-324.
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1985

Krasnianski A, Schulz-Schaeffer, W. J. Kallenberg K, Meissner B, Collie D. A, Roeber S, Bartl M, Heinemann U, Varges D, Kretzschmar H. A, & Zerr I. (1985)
Photo-induced crosslinking of prion protein oligomers and prions Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide
Kretzschmar H.A, DeArmond S.J, & Forno L.S. (1985)
Measurement of GFAP in hepatic encephalopathy by ELISA and transblots.
J. Neuropathol. Exp. Neurol. 44, 459-471.
Sobel D.F, Baker E, Anderson B, & Kretzschmar H. (1985)
Cerebral amyloid angiopathy associated with massive intracerebral hemorrhage.
Neuroradiology 27, 318-321.