Zentrum für Neuropathologie und Prionforschung



Prof. Dr. med. J. Herms

[2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001] [2000] [1999] [1998] [1997] [1996] [1995] [1994] [1993]


Unterrainer M, Winkelmann I, Suchorska B, Giese A, Wenter V, Kreth FW, Herms J, Bartenstein P, Tonn JC, & Albert NL (2018)
Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.
Eur J Nucl Med Mol Imaging. 2018 Feb 27. doi: 10.1007/s00259-018-3969-4.
nach oben


Blazquez-Llorca L, Valero-Freitag S, Rodrigues EF, Merchán-Pérez Á, Rodríguez JR, Dorostkar MM, DeFelipe J, & Herms J (2017)
High plasticity of axonal pathology in Alzheimer's disease mouse models.
Acta Neuropathol Commun.5(1):14.
Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, Deussing JM, & Herms J (2017)
Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD).
Neuropharmacology. [Epub ahead of print]
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Herms J, Haass C, & Rominger A (2017)
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
Front Aging Neurosci.9:8
Schön C, & Herms J (2017)
In Vivo Imaging of Tau Aggregates in the Mouse Retina
Methods Mol Biol. 1523:361-368
Zhu K, Xiang X, Filser S, Marinkovic P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Herms J, & Gunnersen JM (2017)
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
Biol Psychiatry. [Epub ahead of print],
Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A, & Herms J (2017)
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex
EMBO Mol Med. 9(5):716-731
nach oben


Herms J, & Dorostkar MM (2016)
Dendritic Spine Pathology in Neurodegenerative Diseases
Annu Rev Pathol., 11:221-50
Schön C, Asteriti S, Koch S, Sothhilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, & Michalakis S (2016)
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia
Hum Mol Genet, 25(6):1165-75
Ovsepian SV, Blazquez-Llorca L, Freitag SV, & Herms J (2016)
Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors
Cereb Cortex. [Epub ahead of print]
Brendel M, Jaworska A, Probst F, Overhoff F, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, & Rominger A (2016)
Small-Animal PET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models
J Nucl Med, 57(5):792-8
Overhoff F, Brendel M, Jaworska A, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, & Rominger A (2016)
Automated Spatial Brain Normalization and Hindbrain White Matter Refence Tissue Give Improved [18F]-Florbetaben PET Quantitation in Alzheimer’s Model Mice
J Nucl Med, 10:45
Brendel M, Probst F, Jaworska A, Overhoff F, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger K, Haass C, Herms J, & Rominger A (2016)
Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple Tracer PET Study.
J Nucl Med, 57(6):954-60
Shi Y, Dorostkar MM, & Herms J (2016)
Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease
Acta Neuropathol, 131(2):235-46
nach oben


Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming C, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, & Rominger A (2015)
Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
PLoS ONE. 10(2):e0116678
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming C, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, & Rominger A (2015)
Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Mol. Psychiatry, 20(10):1179-87
Thon N, Kunz M, Lemke L, Jansen NL, Kreth S, Lutz J, Egensperger R, Giese A, Herms J, Weller M, Kretzschmar HA, Tonn JC, La Fougère C, & Kreth FW (2015)
Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.
Int J Cancer.136(9):2132-45
Filser S, Ovsepyan S, Masana M, Brandt-Elvang A, Volbracht C, Müller MB, Jung CK, & Herms J (2015)
Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions.
Biol Psychiatry. 77(8):729-39
Blazquez-Llorca L, Hummel E, Zimmerman H, Burgold S, Rietdorf J, & Herms J (2015)
Correlation of two-photon in vivo imaging and FIB/SEM microscopy
J Microsc. 259(2):129-36
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel A, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, & Haass C (2015)
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Nature. 526(7573):443-7
Shi Y, Peters F, Blazquez-Llorca L, Filser S, Shi S, Dorostkar MM, & Herms J (2015)
Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease
Acta Neuropathol. 129(6):909-20
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming C, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, & Rominger A (2015)
Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
Mol. Psychiatriy, 20(10):1141
Dorostkar MM, Blazquez-Llorca L, & Herms J (2015)
Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities.
Acta Neuropathol. 130(1):1-19
Jung CK, Keppler K, Steinbach S, Blazquez-Llorca L, & Herms J (2015)
Fibrillar amyloid plaque formation precedes microglial activation
PLoS ONE. 10(3):e0119768
Ochs S, Dorostkar M, Aramuni G, Schön C, Filser S, Kremer A, van Leuven F, Ovsepian S, & Herms J (2015)
Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin
Mol Psychiatry, in press
nach oben


Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, & Rominger A (2014)
Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET
Neuroimage 2014, 84:843-53
Kleele L, Wiliams P, Stern S, Weigand E, Engerer P, Naumann R, Hartmann J, Karl R, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, & Misgeld T (2014)
An assay to image neuronal microtubule dynamics in mice.
Nat Commun., 5:4827
Dorostkar MM, Burgold S, Filser S, Barghorn S, Schmid B, Anumala UR, Hillen H, Klein C, & Herms J (2014)
Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model
Brain. 137(Pt 12):3319-2
Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F, & Herms J (2014)
Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.
Transl Psychiatry. 2014 Dec 16;4:e489. doi: 10.1038/tp.2014.132.
Herms J (2014)
In memoriam: Hans A. Kretzschmar (1953 – 2014)
Brain Pathol., 2014, 24(3):311-2
Burgold S, Filser S, Dorostkar MM, Schmidt B, & Herms J (2014)
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
Acta Neuropathol Commun.,2014, 2(1):30
Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Herms J, Hugo HH, Schulte M, & Möller P (2014)
Molecular profiling of chordoma
Int J Oncol 2014, 44(4):1041-55
Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A, & Kreth FW (2014)
Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients.
Acta Neurochir 2014, 156(8):1427-40
Neuner J, Ovsepian S, Dorostkar MM, Filser S, Gupta A, Michalakis S, Biel M, & Herms J (2014)
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
Nat Commun.2014, 5:3915
Neuner J, Filser S, Michalakis S, Biel M, & Herms J (2014)
A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network
Sci Rep. 2014, 4:3931
nach oben


Ovsepian SV, & Herms J (2013)
Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system
Neurobiology of Aging 2013, 34(11):2517-24
Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar HA, & Herms J (2013)
Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease
J Cell Mol med. 2013. 17(2):293-302
Honarnejad K, Daschner A, Giese A, Zall A, Schmidt B, Szybinska A, Kuznicki J, & Herms J (2013)
Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease.
PLoS One. 2013;8(11):e80645. doi: 10.1371/journal.pone.0080645
Ovsepian SV, O'Leary VB, Zaborsky L, Herms J, & Oliver Dolly J (2013)
Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forbrain cholinergic neurons
Brain Struct Funct. (2013, in press)
Hoffmann NA, Dorostkar MM, Goedert M, & Herms J (2013)
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
PLoS One. 2013;8(11):e80645. doi: 10.1371/journal.pone.0080645
Anumala UR, Gu J, Lo Monte F, Kramer T, Heyny-von-Haußen R., Hölzer J., Goetschy-Meyer V., Schön C, Mall G, Hilger I, Czech C, Herms J, & Schmidt B (2013)
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer’s disease brains
Bioorganic & Medicinal Chemistry. 2013, 21(17):5139-44
Ovsepian SV, & Herms J (2013)
Cholinergic neurons-keeping check on amyloid β in the cerebral cortex
Front Cell Neurosc. 2013, 7:252, 2013
Honarnejad K, Kirsch AK, Daschner A, Szybinska A, Kuznicki J, & Herms J (2013)
FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer's disease
J Biomol Screen. 2013, 18(10):1309-20
Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, & Haass C (2013)
Longitudinal Assessment of Cerebral β-Amyloid Deposition in Mice Overexpressing Swedish Mutant β-Amyloid Precursor Protein Using 18F-Florbetaben PET
J Nucl Med. 2013, 54(7):1127-34, 2013
Mori K, Lammich S, Mackenzie IRA, Forné I, Zilow S, Kretzschmar HA, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, & Haass C (2013)
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
Acta Neuropathologica Published Online DOI: 10.1007/s00401-013-1088-7
nach oben


Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar HA, & Herms J (2012)
Presenilins: Role in calcium homeostasis
Int J Biochem Cell Biol. 2012, 44(11):1983-1986
Jung CK, & Herms J (2012)
Role of APP for dendritic spine formation and stability
J Neurochem. 2012, 119(5):1064-73
Jung CK, & Herms J (2012)
Structural Dynamics of Dendritic Spines are Influenced by an Environmental Enrichment – an in vivo Imaging Study
Cereb Cortex 24(2):377-84
Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, Kretzschmar HA, & Herms J (2012)
Amyloid plaque formation precedes dendritic spine loss
Acta Neuropathol. 2012, 124(6):797-807
Brucker D, & Herms J (2012)
A Window into Metastasis
Sci Translational Medicine, 2012, 4(158):158fs39
Göbel W, Brucker D, Kienast Y, Johansson A, Kniebühler G, Rühm A, Eigenbrod S, Fischer S, Goetz M, Kreth FW, Erhardt A, Stepp H, Irion KM, & Herms J (2012)
Optical needle endoscope for safe and precice stereotactically guided biopsy sampling in neurosurgery
Opt Express, 2012, 20(24):26117-26, 2012
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, & Herms J (2012)
Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice
PLoS One. 2012, 7(12):e53547
Dorostkar MM, & Herms J (2012)
Arc illuminates Alzheimers’s pathophysiology
Nat. Neurosci.2012, 5(10):1323-5
Boländer A, Kieser D, Voss C, Bauer S, Burgold S, Bittner T, Hölzer J, Heyny-von-Haußen R., Mall G, Goetschy V., Czech C, Knust H, Berger R, Herms J, Hilger I, & Schmidt B (2012)
Bis(arylvinyl)pyrazines, -pyrimidines, and –pyridazines As Imaging Agents for Tau Fibrils and β-Amyloid Plaques in Alzheimer’s Disease Models
J Med Chem. 2012, 31.55(21):9170-80
Hokkanen S, Feldmann H, Ding H, Bojarski L, Kretzschmar H.A, Wolf E, & Herms J (2012)
Lack of Pur-alpha alters postnatal brain development and causes megalencephaly
Hum Mol Genet, 21(3):473-84.
Frick A, Schmidt F, Priller M, Pagella P, von Bueren A, Peraud A, Tonn J, Herms J, Rutkowski S, & Kretzschmar H.A (2012)
Proper cerebellar development requires expression of beta1-integrin in Bergmann glia, but not in granule neurons
Glia, 60:820–832 (cover story)
nach oben


Kunz M, Thon N, Hartmann C, Egensperger R, Herms J, Geisler J, la Fougere C, Lutz J, Linn J, Kreth S, von Deimling A, Tonn JC, Kretzschmar HA, Pöpperl G, & Kreth FW (2011)
Hot spots in dynamic18FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas.
Neuro Oncol. 2011 Feb 3.
Scheibe S, Dorostkar MM, Seebacher D, Uhl R, Lison F, & Herms J (2011)
4D in vivo 2-photon laser scanning fluorescence microscopy with sample motion in 6 degrees of freedom
J. Neurosci Methods. 2011, 200(1):47-53
Capell A, Liebscher S, Fellerer K, Brouwers S, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, & Haass C (2011)
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase
J. Neurosci. 2011, 31(5):1885-1894
von Baumgarten LD, Brucker D, Tirniceru AL, Kienast Y, Grau S, Burgold S, Herms J, & Winkler F (2011)
Bevacizumab has differential and dose-dependent effects on glioma blood vessels and tumor cells
Clin Cancer Res. 2011, 17(19):6192-205
Hüls S, Högen T, Vassallo N, Danzer KM, Hengerer B, Giese A, & Herms J (2011)
AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers
J. Neurochem. 2011 1471-4159
Zou C, Crux S, Marinesco S, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, & Herms J (2011)
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis
EMBO J. 2016, 35(20):2213-2222
Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, & Herms J (2011)
Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo
J Neurochem. 2011, 119(5):1064-73
Lorenz A, Hartmann W, von Bueren A, Kool M, Li S, Peraud A, Tonn J, Herms J, Xiang M, Rutkowski S, & Kretzschmar H.A (2011)
Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Oncogene, 30(47):4721-30.
nach oben


Kienast Y, von Baumgarten L, Fuhrmann M, Klinkert WE, Goldbrunner R, Herms J, & Winkler F (2010)
Real-time imaging reveals the single steps of brain metastasis formation.
Nat Med. 2010 Jan;16(1):116-22.
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson TJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, & Lichtenthaler SF (2010)
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
J Neurosci. 2010 Jun 30;30(26):8974-83.
Burgold S, Bittner T., Dorostkar MM, Kieser D, Fuhrmann M, Mitteregger-Kretzschmar G, Kretzschmar HA, Schmidt B, & Herms J (2010)
In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks.
Acta Neuropathol. 2010, 121(3):327-35
Fuhrmann M, Bittner T., Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, & Herms J (2010)
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Nat Neurosci. 2010 Apr;13(4):411-3.
Bittner T., Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger-Kretzschmar G, Kretzschmar HA, LaFerla FM, & Herms J (2010)
Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer’s Disease Mice.
PLoS ONE, Nov 2010, 5, 11 / e15477
Johansson A, Palte G, Schnell O, Tonn JV, Herms J, & Stepp H (2010)
5-Aminolevulinc Acid-induced Protoporphyrin IX levels in tissue of human malignant brain tumors
Photochem. Photobiol. 2010, 10.1111/j.1751-1097
nach oben


Bittner T., Fuhrmann M, Burgold S, Volbracht C, Steiner H, Mitteregger G, Kretzschmar H, Haass, & Herms J (2009)
Gamma-Secretase inhibition reduces spine density in vivo via an APP-dependent pathway.
J Neurosci. 2009 Aug 19;29(33):10405-9.
Dewachter I, Filipkowski R.K, Priller C, Neyton J, Ris L, Terwel D, Gysemans M, Borghgraef P, Croes S, Godaux E, Kaczmarek L, Herms J, & Van Leuven F. (2009)
Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.
Neurobiol. of Aging 30:241-56.
Kienast Y, v. Baumgarten L, Fuhrmann M, Klinkert W. E, Goldbrunner R, Herms J., Winkler F, & Journal Artikel (2009)
The evolution of brain metastasis formation: real-time imaging reveals its mandatory and inefficient steps.
Nature Med. (in press) * shared senior authorship
Mitteregger G, Korte S, Herms J, & Kretzschmar HA. (2009)
Role of copper and manganese in prion disease progression.
Brain Res. 2009 Oct 6;1292:155-64. Epub 2009 Jul 25.
weiter Abstract (PDF)
Priller C, Mitteregger G, Paluch S, Vassallo N, Staufenbiel M, Kretzschmar HA, Jucker, & Herms J. (2009)
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.
Neurobiol Aging 30:1227-37
Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn J.C, & Kreth F.W. (2009)
Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only.
Neurosurg. Psychiatry 80:1134-9
Winkler F, Kienast Y, Fuhrmann M, von Baumgarten L, Burgold S, Mitteregger G, Kretzschmar HA, & Herms J. (2009)
Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis.
Glia. 2009 Sep;57(12):1306-15.
weiter Abstract (PDF)
nach oben


Bojarski L, Herms J, & Kuznicki J (2008)
Calcium dysregulation in Alzheimer's disease.
Neurochem Int. 2008 Mar-Apr;52(4-5):621-33.
Grau S.J, Trillsch F, von Lüttichau I, Nelson P.J, Herms J, Tonn J.C, & Goldbrunner R.H (2008)
Lymphatic phenotype of tumor vessels in malignant gliomas.
Neuropath. Appl. Neurobiol. 34:675-9.
Linn J, Herms J, Dichgans M, Bruckmann H, Fesl G, Freilinger T, & Wiesmann M. (2008)
Subarachnoid hemosiderosis and superficial cortical hemosiderosis in cerebral amyloid angiopathy
Am. J. Neuroradiol. 29:184-6.
Mehrkens JH, Pöpperl G, Rachinger W, Herms J, Seelos K, Tatsch K, Tonn JC, & Kreth FW (2008)
The positive predictive value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET in the diagnosis of a glioma recurrence after multimodal treatment.
J Neurooncol. 2008 May;88(1):27-35.
Ruiter M, Kretzschmar HA, & Herms J (2008)
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas.
Acta Neuropathol 115(3):367-8
Stummer W, Beck T, Beyer W, Mehrkens JH, Obermeier A, Etminan N, Stepp H, Tonn JC, Baumgartner R, Herms J, & Kreth FW (2008)
Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report.
J Neurooncol. 2008 Mar;87(1):103-9.
nach oben


Fuhrmann M, Mitteregger G, Kretzschmar H, & Herms J. (2007)
Dendritic pathology in prion disease starts at the synaptic spine.
J. Neurosci. 27:6224-6233.
Grau S.J, Trillsch E, Herms J, Thon N, Nelson P.J, Tonn J.C, & Goldbrunner R. (2007)
Expression of VEGFR3 in glioma endothelium correlates with tumor grade.
J. Neuroconcol. 82:141-50.
Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhoevd C, Reichert A, Kretzschmar H.A, Haass C, & Herms J (2007)
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.
J. Neurochem. 102:1264-75.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Onodera T, Kretzschmar H, & Herms J. (2007)
The cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
J. Neurochem. 100:358-67.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Mitteregger G, Onodera T, Kretzschmar HA, & Herms J (2007)
Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
J Neurochem 110, 2: 358-367
Popperl G, Kreth F.W, Mehrkens J.H, Herms J, Seelos K, Koch W, Gildehaus F.J, Kretzschmar H.A, Tonn J.C, & Tatsch K. (2007)
FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading.
Eur J Nucl Med Mol Imaging 34(12):1933-1942
Priller C, Dewachter I, Vassallo N, Pace C, Kretzschmar H, van Leuven F, & Herms J. (2007)
Mutant Presenilin 1 alters synaptic transmission in cultured hippocampal neurons.
J. Biol. Chem. 282:1119-27.
Ring S, Weyer S, Kilian S, Waldron E, Pietrzik C.U, Filippov M, Herms J, Eckman C.B, Korte M, Wolfer D.P, & Müller U. (2007)
The secreted APPsa domain is sufficient to rescue the anatomical, behavioural, and electrophysiological abnormalities of APP deficient mice.
J. Neurosci. 27:7817-26.
nach oben


Fuhrmann M, Bittner T., Mitteregger G, Haider N, Moosmang S, Kretzschmar H, & Herms J. (2006)
Loss of the cellular prion protein affects the Ca(2+) homeostasis in hippocampal CA1 neurons.
J Neurochem 98 (6), 1876-85.
Fuhrmann M, Mitteregger G, Moosmang S, Kretzschmar H, & Herms J. (2006)
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.
J. Neurochem. 98:1876-85.
Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, & Kretzschmar H.A. (2006)
Prion protein induced signaling cascades in monocytes.
Biochem Biophys Res Commun 340 (1):13-22
Popperl G, Kreth F. W, Herms J, Koch W, Mehrkens J. H, Gildehaus F. J, Kretzschmar H. A, Tonn J. C, & Tatsch K (2006)
Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?
J Nucl Med 47 (3): 393-403
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, & Herms J (2006)
Synapse formation and function is modulated by the amyloid precursor protein.
J Neurosci 26 (27): 7212-21
nach oben


Giese A, Buchholz M, Herms J, & Kretzschmar H. (2005)
Mouse brain synaptosomes efficiently accumulate copper-67 by two distinct processes independent of cellular prion protein.
J. Molecular Neurosci. 27:347-54.
Rachinger W, Goetz C, Pöpperl G, Gildehaus F.J, Kreth F.W, Holtmannspötter M, Herms J, Koch W, Tatsch K, & Tonn J.C. (2005)
Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas.
Neurosurgery 57:505-11.
Uspenskaia O, Liebetrau M, Herms J, Danek A, & Hamann G.F. (2005)
Age-related changes of collagen type IV expression in human cerebral microvessels.
BMC Neuroscience 5:37
Vasallo N, Herms J, Behrens C, Krebs B, Windl O, & Kretzschmar H. (2005)
Activation of phosphatidylinositol 3-kinase by copper bound prion protein and its role in cell survival.
Biochem. Biophys. Res. Commun. 332:75-82.
Vassallo N, Herms J, Behrens C, Krebs B, Saeki K, Onodera T, Windl O, & Kretzschmar H.A. (2005)
Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival.
Biochem. Biophys. Res. Commun. 332, 75-82.
Weis E, Albrecht C.F, Herms J, Behnke-Mursch, Pekrun A, Brockmann K, & Hess C.F. (2005)
Malignant ectomesenchymoma of the cerebrum. Case report and discussion of therapeutic options.
Eur. J. Pediatr. 164:345-49.
nach oben


Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, & Müller U (2004)
Cortical Dysplasia Resembling Human Type 2 Lissencphaly in Mice Lacking all three APP-Family Members.
EMBO 23:4106-4115
Özen Ö, Krebs B, Hemmerlein B, Pekrun A, Kretzschmar H, & Herms J (2004)
Expression of matrix metalloproteinases and their inhibitors in medulloblastomas and their prognostic relevance.
Clinical CancerResearch. Clin Cancer Res 10:4746-4753
Peraud A, Herms J, Schlegel J, Müller P, Kretzschmar H, & Tonn J.-C. (2004)
Recurrent spinal cord astrocytoma with intraventrucular seeding.
Childs Nerv Syst 20:114-118
Schober F, Kretzschmar HA, & Herms J (2004)
Bcl-2 expression inversely correlates with tumor cell differentiation in medulloblastoma
Neuropathol Appl Neurobiol 30: 513-521
nach oben


Bönnemann C.G, Thompson T.G, Van der Ven P.F.M, Goebel H, Warlo I, Vollmers B, Reimann J, Herms J, Gautel M, Takada F, Beggs A.H, Fürt D.O, Kunkel L.M, Hanefeld F, & Schröder R. (2003)
Filamin C accumulation is a strong but non-specific immunohistochemical marker of core formation in muscle.
J. Neurol. Sci. 206:71-8.
Erdlenbruch B, Schinkhof C, Kugler W, Heinemann D.E, Herms J, Eibl H, & Lakomek M. (2003)
Intracarotid administration of short-chain alkylglycerols for increased delivery of methotrexate to the rat brain.
Br. J. Pharmacol. 139:685-94.
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, & van Leuven F. (2003)
Captative calcium entry is directly attenuated by mutant presinilin-1, independent of the expression of the amyloid precursor protein.
J Biol Chem; 278(4): 2484 - 2489.
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, & Van Leuven F. (2003)
Capacitative calcium entry is directly alleviated by mutant Presenilin-1, independent on the expression of amyloid precursor protein.
J. Biol. Chem. 278:2484-9
Hopt A, Korte S, Fink H, Panne U, Niessner R, Jahn R, Kretzschmar HA, & Herms J (2003)
Methods for studying synaptosomal copper release.
J.Neurosci.Methods (2003) 128 (1-2), 159 -172
Korte S, Vasallo N, Kramer M.L, Kretzschmar H.A, & Herms J. (2003)
Prion protein affects L-type voltage gated calcium channels.
J. Neurochem. 87:1037-42.
Korte S, Vassallo N, Kramer M.L, Kretzschmar H.A, & Herms J (2003)
Modulation of L-type voltage-gated calcium channels by recombinant prion protein.
J.Neurochem.(2003) 87 (4), 1037 -1042
Van der Knaap M, van Berkel C, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemse M.A.A, Plecko B, Proud C.G, & Pronk J.C. (2003)
The widening phenotype of vanishing white matter: early onset and involvement of organs other than the brain.
Am. J. Hum. Genet. 73:1199-207
Vassallo N, & Herms J (2003)
Cellular prion protein function in copper homeostasis and redox signalling at the synapse.
J.Neurochem. 86(3), 538 - 544
nach oben


Schmidt T, Lindenberg K.S, Krebs A, Schols L, Laccone F, Herms J, Rechsteiner M, Riess O, & Landwehrmeyer G.B. (2002)
Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions.
Ann. Neurol. 51:302-10.
Tschampa H.J, Herms J, Schulz-Schaeffer W, Maruschak B, Windl O, Jastrow U, Zerr I, Steinhoff B.J, Poser S, & Kretzschmar H.A (2002)
Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology
Brain 125:2558-66.
nach oben


Augustin I, Korte S, Kretzschmar H.A, Südhoff T.C, Herms J, & Brose N. (2001)
Nonredundant and redundant roles of Munc13 isoforms in the regulation of neurotransmitter release.
J. Neurosci. 21:10-17.
Augustin I, Korte S, Rickmann M, Kretzschmar H.A, Sudhof T.C, Herms J.W, & Brose N. (2001)
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice.
J. Neurosci. 21, 10-17
Brück W, Herms J, Brockmann K, Schulz-Schaeffer W, & Hanefeld F. (2001)
Myelinopathia centralis diffusa (Vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development.
Ann. Neurol. 50:532-36.
Herms J.W, Tings T, Dunker S, & Kretzschmar H.A. (2001)
Prion Protein Affects Ca(2+)-Activated K(+) Currents in Cerebellar Purkinje Cells.
Neurobiol. Dis. 8, 324-330.
Middel P, Reich K, Polzien F, Blaschke V, Hemmerlein B, Herms J, Korabiowska M, & Radzun H.J. (2001)
Interleukin-16 expression and phenotype of interleukin-16 producing cells in Crohn`s disease.
Gut 49:795-803.
Mueller W, Lass U, Herms J, Kuchelmeister K, Bergmann M, & von Deimling A. (2001)
Clonal analysis in glioblastoma with epithelial differentiation.
Brain Pathol. 11:39-43.
Papos M, Pekrun A, Herms J.W, Behr T.M, Meller J, Rustenbeck H.H, Kretzschmar H.A, & Becker W. (2001)
Somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma: a case report.
Pediatr. Radiol.  31, 169-172.
Papòs M, Pekrun A, Herms J, Behr T.M, Meller J, Rustenbeck H.H, Kretzschmar H.A, & Becker W (2001)
Case report: somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma.
Pediatric Radiol. 31:169-72.
Scheil S, Bruderlein S, Liehr T, Starke H, Herms J, Schulte M, & Moller P. (2001)
Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1.
Genes Chromosomes Cancer 32:203-11.
Scheil S, Brüderlein S, Eicher M, Herms J, Herold-Mende C, Steiner H.H, Barth T.F.E, & Möller P. (2001)
Low frequency of chromosomal imbalance in anaplastic ependymomas as detected by comparative genomic hybridization.
Brain Pathol. 11:133-43.
Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C, Gilis M, Geerts H, Moechars D, Kretzschmar H, Godaux E, Van Leuven F, & Herms J. (2001)
Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.
J. Biol. Chem. 276:11539-44.
nach oben


Herms J, Neidt I, Luscher B, Sommer A, Schurmann P, Schroder T, Bergmann M, Wilken B, Probst-Cousin S, Hernaiz-Driever P, Behnke J, Hanefeld F, Pietsch T, & Kretzschmar H.A. (2000)
C-MYC expression in medulloblastoma and its prognostic value.
Int. J. Cancer 89, 395-402.
Herms J.W, Korte S, Gall S, Schneider I, Dunker S, & Kretzschmar H.A. (2000)
Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice.
J. Neurochem. 75, 1487-1492.
nach oben


Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, Schurmann P, Windl O, Brose N, & Kretzschmar H. (1999)
Evidence of presynaptic location and function of the prion protein.
J. Neurosci.  19, 8866-8875.
nach oben


Brown D.R, Besinger A, Herms J.W, & Kretzschmar H.A. (1998)
Microglial expression of the prion protein.
Neuroreport 9, 1425-1429.
Herms J.W, Gall S, Tings T, Dunker S, & Kretzschmar H.A. (1998)
Pathophysiological consequences of the loss of copper binding ability of pf Prnp0/0 mice at the neuronal membrane.
Clin. Neuropathol. 17, 254.
Herms J. W, Tings T, Dunker S, & Kretzschmar H. A. (1998)
Prion protein modulates calcium activates potassium currents in cerebellar Purkinje cells.
Soc.Neurosci.Abst. 24. 1998.
nach oben


Herms J, Behnke J, Bergmann M, Christen HJ, Kolb R, Wilkening M, Markakis E, Hanefeld F, & Kretzschmar HA (1997)
Potential Prognostic Value of C-erbB-2 Expression in Medulloblastomas in Very Young Children
J. of Pediatric Hem/Onc. 1997, 19(6):510-515
Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, & Groschup M (1997)
Cell death in prion disease.
J Neural Transm Suppl. 1997;50:191-210.
Brown D.R, Herms J, Schmidt B, & Kretzschmar H.A. (1997)
PrP and b-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells.
Eur. J. Neurosci. 9, 1162-1169.
Brown D.R, Qin K, Herms J.W, Madlung A, Manson J, Strome R, Fraser P, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A. Westaway D. and, & Kretzschmar H. (1997)
The cellular prion protein binds copper in vivo.
Nature 390, 684-687.
Herms J, Madlung A, Brown D.R, & Kretzschmar H.A. (1997)
Increase of intracellular free Ca2+ in microglia activated by prion protein fragment.
Glia 21, 253-257.
nach oben


Herms J. W, Madlung A, Brown D. R, & Kretzschmar H. A. (1996)
Prion protein fragment induces increase of intracellular free Ca2+ in cultured rat microglia.
Soc.Neurosci.Abst. 22, 285. 1996.
Kretzschmar H.A, Giese A, Brown D.R, Herms J, Schmidt B, & Groschup M. (1996)
Transmissible Subacute Spongiform Encephalopathies: Prion Disease
Prion Disease 97-106.
nach oben


Herms J.W, Kretzschmar H.A, Titz S, & Keller B.U. (1995)
Patch-clamp analysis of synaptic transmission to cerebellar Purkinje cells of prion protein knockout mice.
Eur. J. Neurosci. 7, 2508-2512.
nach oben


Brown D.R, Herms J, & Kretzschmar H.A (1994)
Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment.
Neuroreport 5, 2057-2060.
Herms J, Zurmohle U, Schlingensiepen R, Brysch W, & Schlingensiepen K.H. (1994)
Developmental expression of the transcription factor zif268 in rat brain.
Neurosci. Lett. 165, 171-174.
nach oben


Herms J, Zurmohle U, Brysch W, & Schlingensiepen K.H. (1993)
Ca2+/calmodulin protein kinase and protein kinase C expression during development of rat hippocampus.
Dev. Neurosci. 15, 410-416.
Herms J, Zurmohle U, Schlingensiepen K.H, & Brysch W. (1993)
Transient expression of PKC gamma mRNA in cerebellar granule cells during rat brain development.
Neuroreport  4, 899-902.